DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment spn-E and Dhx36

DIOPT Version :9

Sequence 1:NP_476741.1 Gene:spn-E / 41919 FlyBaseID:FBgn0003483 Length:1434 Species:Drosophila melanogaster
Sequence 2:NP_001101148.1 Gene:Dhx36 / 310461 RGDID:1308767 Length:1000 Species:Rattus norvegicus


Alignment Length:890 Identity:254/890 - (28%)
Similarity:403/890 - (45%) Gaps:163/890 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    32 LMATKFKSSE------VPNRELIGTDYVS-KIVAKEKCLLN--GTLLNEQPQGKRIRTLDDLDTD 87
            :.|...|.||      .|.....||:..| |.:..||.|.|  ..|||::.:..||.....:|.|
  Rat    94 VQAKNDKDSEAQISWFAPEDHGYGTEVSSEKKINSEKKLDNQEKKLLNQEKKTYRITDKSYIDRD 158

  Fly    88 DE----------GEETEI-------RRDDEYYKKFRFNLNRDKNLSIYAKREEILAAINAHPVVI 135
            .|          |.:.::       :.|..|.:..||.    |.|..|..::|::..||.|.|.:
  Rat   159 SEYLLQQNEPNLGLDQQLLEDLQKKKTDPRYIEMQRFR----KKLPSYGMQKELVNLINNHQVTV 219

  Fly   136 IKGETGCGKTTQVPQYILDEAYKS--GKYCNIVVTQPRRIAAISIANRVCQER--EWQQNTVCSF 196
            |.|||||||||||.|:|||...:.  |..|.||.||||||:|||:|.||..||  .........:
  Rat   220 ISGETGCGKTTQVTQFILDNYIERGIGSACRIVCTQPRRISAISVAERVAAERAESCGNGNSTGY 284

  Fly   197 QVGLHRPNSLEDTRLLYCTTGVLLNNLINNKTLTHYTHIVLDEVHERDQNMDFLLIVVRRLLATN 261
            |:.|......:...:||||||::|..|.::..|:..:||||||:|||:...|.|:.|::.||...
  Rat   285 QIRLQSRLPRKQGSILYCTTGIILQWLQSDSRLSSVSHIVLDEIHERNLQSDVLMTVIKDLLHFR 349

  Fly   262 SRHVKIILMSATIDAKELSDYFTTTNSIP------PVIT-------------------------- 294
            | .:|:||||||::|::.|:||.....|.      ||:.                          
  Rat   350 S-DLKVILMSATLNAEKFSEYFGNCPMIHIPGFTFPVVEYLLEDIIEKIRYFPEQKEHRSQFKRG 413

  Fly   295 -----TNHRRKHSIEKFYRDQLGSIIWNEEDVGHQQVPEINKHGYRAAVKIIVIID----NMERK 350
                 .|.:.|...|..|:::     |      ...:.|:......:.:.::.::|    ::...
  Rat   414 FMQGHVNRQEKEEKEAIYKER-----W------PAYIKELQTRYSASTIDVLEMMDDDKVDLNLI 467

  Fly   351 AAIQSRQSYDEALRY-------GAVLIFLPGIYEIDTMAENL--TCMLENDPNIKVSIVRCFSLM 406
            ||:         :||       ||:|:||||...|.|:.:.|  ..|.::|   :..|:...|||
  Rat   468 AAL---------IRYIVLEEEDGAILVFLPGWDNISTLHDLLMSQVMFKSD---RFLIIPLHSLM 520

  Fly   407 TPENQRDVFNPPPPGFRKIILTTNIAESSITVPDVSYVIDFCLAKVKVT--DTASSFSSLRLTWA 469
            ...||..||...|||.|||::.|||||:|||:.||.||||.  .|:|.|  ||.::.|::...|.
  Rat   521 PTVNQTQVFKKTPPGVRKIVIATNIAETSITIDDVVYVIDG--GKIKETHFDTQNNISTMSAEWV 583

  Fly   470 SKANCRQRAGRVGRLRSGRVYRMVNKHFYQREMPEFGIPEMLRLPLQNSVLKAKVLNMGSPVEIL 534
            ||||.:||.||.||::.|..|.:.| ......:.::.:||:||.||:...|:.|:|.:|.....|
  Rat   584 SKANAKQRKGRAGRVQPGHCYHLYN-GLRASLLDDYQLPEILRTPLEELCLQIKILRLGGIAYFL 647

  Fly   535 ALALSPPNLSDIHNTILLLKEVGALYLTVDGIYDPLDGDLTYWGTIMSRLPLDTRQSRLIILGYI 599
            :..:.||:...:..:|..|.|:.||        |..: :||..|..::|||::....::|:.|.:
  Rat   648 SRLMDPPSDEAVVLSIKHLMELSAL--------DKQE-ELTPLGVHLARLPVEPHIGKMILFGAL 703

  Fly   600 FNMLEEAIIIAAGLSTPGLFAHEGGRSQLGDSFWMHYIFSDGSGSDLVAIWRVYLTYLNIVENGH 664
            |..|:..:.|||.||....|....|:.::.|:  .....:..:.||       :||.:|..|...
  Rat   704 FCCLDPVLTIAASLSFKDPFVIPLGKEKIADA--RRKELAKETRSD-------HLTVVNAFEGWE 759

  Fly   665 D-QESAIRWAK----RFHVSLRSLKEIHLLVQELRVRCTHLGLIP--FPVNPN-QMMDDREKAIM 721
            : :....|:.|    .:.:|..:|:.:|.:..:........|.:.  .|.:|. .:..|.||  :
  Rat   760 EAKRRGFRYEKDYCWEYFLSSNTLQMLHNMKGQFAEHLLGAGFVSSRSPKDPKANINSDNEK--I 822

  Fly   722 LKVIIAGAFYP-------NYFTRSKESCADTDRNIYQTISGHDPCRTVYFTNFKPAYMGELYTRR 779
            :|.:|....||       |...:.|.....|..:  ..:|.|.....|..|:|.  |...:|..:
  Rat   823 IKAVICAGLYPKVAKIRLNLGKKRKMVKVHTKSD--GLVSIHPKSVNVEQTDFH--YNWLIYHLK 883

  Fly   780 IKE----LFQEVRIPPENM-----DVTFQEGSQKVFVTFKQDDWI 815
            ::.    |:....:.|..:     |::.|:...:..:..  |:||
  Rat   884 MRTSSIYLYDCTEVSPYCLLFFGGDISIQKDKDQEIIAV--DEWI 926

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
spn-ENP_476741.1 HrpA 113..>697 CDD:224557 201/644 (31%)
TUDOR 892..1016 CDD:395449
Dhx36NP_001101148.1 HrpA 187..893 CDD:224557 225/760 (30%)
Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79 257..309 19/51 (37%)
DEAH box. /evidence=ECO:0000255|PROSITE-ProRule:PRU00541 326..329 2/2 (100%)
RecA-like domain 2. /evidence=ECO:0000250|UniProtKB:Q05B79 379..620 73/266 (27%)
Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79 490..549 24/61 (39%)
Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:Q9H2U1 509..520 3/13 (23%)
WH domain. /evidence=ECO:0000250|UniProtKB:Q05B79 621..690 24/77 (31%)
Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79 630..689 17/67 (25%)
OB-fold-like subdomains. /evidence=ECO:0000250|UniProtKB:Q05B79 833..897 12/67 (18%)
Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79 841..852 2/10 (20%)
Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79 862..892 6/31 (19%)
Necessary for nuclear and nucleolar caps localizations. /evidence=ECO:0000250|UniProtKB:Q9H2U1 1..192 24/97 (25%)
Required for the pre-miR-134 transport. /evidence=ECO:0000269|PubMed:23651854 1..96 0/1 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..53
Required for recruitment to cytoplasmic stress granules. /evidence=ECO:0000250|UniProtKB:Q9H2U1 1..43
Required for G4-DNA-and G4-RNA-binding. /evidence=ECO:0000250|UniProtKB:Q9H2U1 45..97 0/2 (0%)
DSM (DHX36-specific motif). /evidence=ECO:0000250|UniProtKB:Q05B79, ECO:0000250|UniProtKB:Q9H2U1 45..67
RecA-like domain 1. /evidence=ECO:0000250|UniProtKB:Q05B79 98..378 105/284 (37%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1643
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D278674at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.820

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