DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spn-E and Tdrd9

DIOPT Version :9

Sequence 1:	NP_476741.1	Gene:	spn-E / 41919	FlyBaseID:	FBgn0003483	Length:	1434	Species:	Drosophila melanogaster
Sequence 2:	XP_017450003.1	Gene:	Tdrd9 / 299343	RGDID:	1306942	Length:	1396	Species:	Rattus norvegicus

Alignment Length:	1452	Identity:	462/1452 - (31%)
Similarity:	732/1452 - (50%)	Gaps:	215/1452 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 EVMDFFDFSKELKRV--AAAPQGYISSDPR--LMATKFKSSEVPNRELIGTDYV-SKIVAKEKCL 63
            ::.|:|...|.:..|  ...|..:.:..||  :..::...||.|..:  ..|.| :..:|:....
  Rat     9 QINDWFTIGKTVTNVELLGLPPAFPAEAPREEVQRSEEVPSEAPTAQ--AQDPVKATALARPASA 71

  Fly    64 LNGTLLNEQPQGKRIRTLDDLDTDDEGEETEIRRDDE-----------------------YYKKF 105
            ...:|.....:.:.|.....|    |.:|.:|...|:                       .||..
  Rat    72 FGRSLSQRSSEVEYINKYRQL----EAQELDIYGQDQPPSGPGLRSPLAKISNVACIPETTYKYP 132

  Fly   106 RFNLNRDKNLSIYAKREEILAAINAHPVVIIKGETGCGKTTQVPQYILDEAYKSGKYCNIVVTQP 170
            ...:||.|        ||:::.|.::.||||.|.||.||:||:|||:||...:...:||||||||
  Rat   133 DLPINRCK--------EEVISLIESNSVVIIHGATGSGKSTQLPQYVLDHYTQRSAFCNIVVTQP 189

  Fly   171 RRIAAISIANRVCQEREWQQNTVCSFQVGLHRPNSLEDTRLLYCTTGVLLNNLINNKTLTHYTHI 235
            |:|.|.|||..:.:||.|....:..:||||.: .:.|||||:|.||||||..:::.|:|..:||:
  Rat   190 RKIGASSIARWISKERSWTLGGLVGYQVGLEK-TATEDTRLIYMTTGVLLQKIVSAKSLMEFTHV 253

  Fly   236 VLDEVHERDQNMDFLLIVVRRLLATNSRHVKIILMSATIDAKELSDYFT--TTNSIPPVITTNHR 298
            .:||||||.:.|||||:|||:||.||||.||:|||||||:.|:.:|||.  ..|.:.|.......
  Rat   254 FIDEVHERTEEMDFLLLVVRKLLRTNSRFVKVILMSATINCKQFADYFAVPVQNKMNPAYVFEVE 318

  Fly   299 RK-HSIEKFYRDQLGSIIWNEEDVGHQQVPEINKHGYRAAVKIIVIIDNMERK---------AAI 353
            .| |:||::|.:.||.|..:.......:.|.|.|..|..||.:|.:.|:::.|         |..
  Rat   319 GKPHTIEQYYLNDLGHIYHSGLPPYRLEEPVITKDVYEVAVSLIQMFDDLDMKESGNKTWSGAQF 383

  Fly   354 QSRQSYDEALRYGAVLIFLPGIYEIDTMAENLTCMLENDPNIKVSIVRCFSLMTPENQRDVFNPP 418
            .|.:|        :||:||||:.||:.|.|.||.|:..    ::.:....|.:|.|.|.:||..|
  Rat   384 VSERS--------SVLVFLPGLGEINYMHELLTNMIHK----RLQVYPLHSSVTLEEQNNVFLSP 436

  Fly   419 PPGFRKIILTTNIAESSITVPDVSYVIDFCLAKVKVTDTASSFSSLRLTWASKANCRQRAGRVGR 483
            .||:|||||:|||||||:|||||.|||||||.:..|.|..:::.||||:||||.:|.||.||.||
  Rat   437 VPGYRKIILSTNIAESSVTVPDVKYVIDFCLTRTLVCDEDTNYQSLRLSWASKTSCDQRKGRAGR 501

  Fly   484 LRSGRVYRMVNKHFYQREMPEFGIPEMLRLPLQNSVLKAKVLNMGSPVEILALALSPPNLSDIHN 548
            :..|..||::::.|:...:|:..:|||||.||.::|||.|:|:||.|..:||.|||||:||||..
  Rat   502 VSKGYCYRLIHRDFWDSAIPDHVVPEMLRCPLGSTVLKVKLLDMGEPRALLATALSPPSLSDIER 566

  Fly   549 TILLLKEVGALYLTVDGIYD---PLDGDLTYWGTIMSRLPLDTRQSRLIILGYIFNMLEEAIIIA 610
            ||||||||||  |.|.|..:   |.||:||:.|.::::||:..:..:||:||::|..|:|.:|||
  Rat   567 TILLLKEVGA--LAVSGQREDENPHDGELTFLGRVLAQLPVSQQLGKLIVLGHVFGCLDECLIIA 629

  Fly   611 AGLSTPGLFA-----H-EGGRSQLGDSFWMHYIFSDGSGSDLVAIWRVYLTYLNIVENG---HDQ 666
            |.||....|.     | :|.|::      :|  ||..|.||.:|:...:..:....:.|   |.:
  Rat   630 AALSLKNFFTMPFRQHLDGYRNK------VH--FSGSSRSDCLALVEAFRAWQACRQRGELRHPK 686

  Fly   667 ESAIRWAKRFHVSLRSLKEIHLLVQELRVRCTHLGLIPFPVNPNQMMDDRE----KAIMLKVIIA 727
            :. :.|.:..::.::.::|:..|.:||:.|.:...:.   |:|...:.|:|    :..:|:|::|
  Rat   687 DE-LDWGRLNYIQIKRIREVAELYEELKNRISQFNMF---VDPRHPVLDQEYPYKQRFILQVVLA 747

  Fly   728 GAFYPNYFTRSKESCADTDRNIYQTISGHDPCRTVYFTNFKPAYMGELYTRRIKELFQEVRIPPE 792
            |||||||||..:..    :....:.::|.||..||...:..|  .|.||.::::.||:
  Rat   748 GAFYPNYFTFGQPD----EEMAVRELAGRDPKTTVVLKHIPP--YGFLYYKQLQSLFR------- 799

  Fly   793 NMDVTFQEGSQKVFVTFKQDDWIEGSSKYVPVSGRVQSEVYK-------AVMMRQNRVERPIHIM 850
                  |.|..|..|       .:|:..:|..| |..:|.:|       ||.|.|.:|...:.|.
  Rat   800 ------QCGQVKSIV-------FDGAKAFVEFS-RNPTERFKTLPAVNLAVKMSQLKVSLELSIH 850

  Fly   851 NPSAFMSYVQQRGIGDVIEGR-----WIPPTKPLNVELLALP---SVFDKTISGSIT----C--- 900
            ........||...:..:...|     ......|:.|....|.   :|.|..::..:|    |
  Rat   851 AAEEIEGKVQGGSVSKLRNTRVNVDFQKQTVDPMQVSFNTLDRPRTVADLLLTVDVTEVALCAHT 915

  Fly   901 ----IVNCGKF--FFQPQSFEECIRNMSEIFN----APQQLRNYVTNASAIAKGMMVLA-----K 950
                :|..|.|  :...:...|.:|.::...|    .|..:..:        ..::.||     .
  Rat   916 LLLQVVEVGHFWGYRIDERNAELLRQLTAEINRLELVPLPIHPH--------PDLVCLAPFTDYN 972

  Fly   951 RDSYFQRATVIRPENQSNRQPMFYVRFIDYGNCTLLPMQLMRLMPRELTEQYGDLPPRVFECRLA 1015
            ::||| ||.::.....|..     |.|:||||.:.:.:.|:|.:|.:|.|    ||.:..|.::.
  Rat   973 KESYF-RAQILYVSGNSAE-----VFFVDYGNRSHVDLDLLREIPCQLLE----LPFQALEFKIC 1027

  Fly  1016 MVQPS--SVVSGNNRWSTAANDMLKT-VAQCGLIDIEVYSLFNNVAAV----------LIHMRDG 1067
            .::||  |::.|.: ||..||..... |:.|.|: ::|:|:.::|..|          .:::||.
  Rat  1028 KMRPSAKSLICGEH-WSGGANGRFAALVSGCPLL-VKVFSIVHSVLHVDVYRYSGAQDAVNIRDV 1090

  Fly  1068 IINDKLVELMLCRRSDEDYMSRKDHD----FRLRRQESARNLSTAQRQQINEEYLRSCQLPQ--D 1126
            :|.:...||     ::|.|.|::.::    |..:..::..:.|.:...:.:|::|....|..  .
  Rat  1091 LIREGYAEL-----AEESYESKQSYEVLKGFFAKSVDTMPDGSVSSPMKDDEKHLIQILLESFAS 1150

  Fly  1127 HDLPPPPLEKCKTVVMLKGPNSPLECTMRSITRVGLSKRVNIDHLSVNALLLDADPQDHHDHLIV 1191
            :.|..|   .||.|  |.||.:|.|....|:||:...:.|.|:..|:|::::...|.|.|..::|
  Rat  1151 NRLGAP---NCKAV--LHGPFNPYELKCHSLTRISKFRCVWIEKESINSVVISDSPADLHQRMLV 1210

  Fly  1192 AHEIAESRNGQTLTARGTTLMPNVQGFGALMVMLFSPTMQLKCNKEGTSYVSVLGGLGCDPDTNE 1256
            |..::.:..|.|:..|.|:|||::.|..||:.|||:|.|:|:.::||..|..||.|||.:..|..
  Rat  1211 AASLSVNETGSTMLLRETSLMPHIPGLPALLSMLFAPVMELRVDREGKCYTGVLCGLGWNSTTEA 1275

  Fly  1257 PYFAEHDVLINLDVNILEDDVILINQIRYYIDSVFFNFKEENNPAVSVNERVS-IYTQLRSLINR 1320
            |...|||:.:..||....:|::.||.:|..|:.:..:  ..:.|.....||:: :....|..:..
  Rat  1276 PILPEHDIELAFDVCFNVEDIVEINILRAAINKLACD--GPHGPKYLGPERIAQLQENARQKLLG 1338

  Fly  1321 LLC--KDRRYIERNMSNADFEW 1340
            |.|  |.|..|........:||
  Rat  1339 LFCRLKPREKITPQWHEKPYEW 1360

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spn-E	NP_476741.1	HrpA	113..>697	CDD:224557	258/607 (43%)
spn-E	NP_476741.1	TUDOR	892..1016	CDD:395449	31/145 (21%)
Tdrd9	XP_017450003.1	DEXDc	146..327	CDD:214692	93/181 (51%)
		DEXDc	151..292	CDD:238005	80/141 (57%)
		Helicase_C	385..502	CDD:278689	64/128 (50%)
		HA2	590..667	CDD:214852	31/84 (37%)
		TUDOR	924..1026	CDD:278965	28/119 (24%)
		TUDOR	962..1009	CDD:119391	15/52 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350982
Domainoid	1	1.000	175	1.000	Domainoid score	I3562
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H14311
Inparanoid	1	1.050	608	1.000	Inparanoid score	I890
OMA	1	1.010	-	-		QHG47461
OrthoDB	1	1.010	-	-		D253470at33208
OrthoFinder	1	1.000	-	-		FOG0008277
OrthoInspector	1	1.000	-	-		oto96450
orthoMCL	1	0.900	-	-		OOG6_106475
Panther	1	1.100	-	-	LDO	PTHR18934
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6258
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.910