DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spn-E and Dhx37

DIOPT Version :9

Sequence 1:	NP_476741.1	Gene:	spn-E / 41919	FlyBaseID:	FBgn0003483	Length:	1434	Species:	Drosophila melanogaster
Sequence 2:	NP_001099396.2	Gene:	Dhx37 / 288647	RGDID:	1306837	Length:	1150	Species:	Rattus norvegicus

Alignment Length:	838	Identity:	216/838 - (25%)
Similarity:	352/838 - (42%)	Gaps:	184/838 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   115 LSIYAKREEILAAINAHPVVIIKGETGCGKTTQVPQYILDEAYKSGKYCNIVVTQPRRIAAISIA 179
            |.|.|:.:.|:.|:..||:||:.||||.||||||||::.:..| |.:...|.||:|||:||::::
  Rat   248 LPILAEEQAIMEAVAEHPIVIVCGETGSGKTTQVPQFLYEAGY-SSEDSIIGVTEPRRVAAVAMS 311

  Fly   180 NRVCQEREWQQNTVCSFQVGLHRPNSLEDTRLLYCTTGVLLNNLINNKTLTHYTHIVLDEVHERD 244
            .||.:|.......| |:|: .:..|..|:||:.:.|.||||..:..:..|..|..:::||.|||.
  Rat   312 QRVAKEMNLSHRVV-SYQI-RYEGNVTEETRIKFMTDGVLLKEIQKDFLLLKYKVVIIDEAHERS 374

  Fly   245 QNMDFLLIVVRRLLATNS-RH--VKIILMSATIDAKELSD---YFTTTNSIPPVITTNHRR---- 299
            ...|.||.::.|::|..: ||  :|:::||||:..::.:.   .|||.   ||||....|:
  Rat   375 VYTDILLGLLSRIVALRAKRHLPLKLLIMSATLRVEDFTQNQRLFTTP---PPVIKVESRQFPVT 436

  Fly   300 KHSIEKFYRDQLGSIIWNEEDVGHQQVPEINKHGYRAAVKIIVIIDNMERKAAIQSR-------- 356
            .|..::...|......:.:....|:.:|         |..|:|.:.......|:..|
  Rat   437 VHFNKRTPLDDYSGECFRKVCKIHRMLP---------AGGILVFLTGQAEVHALCRRLRKAFPIR 492

  Fly   357 ----QSYDEALRYG-------------AVLIFLPGI------------------YEIDTMAENLT 386
                |..:|....|             |..:.||.|                  .|:|...|.|.
  Rat   493 CSQPQEMEEDSAEGMRRFKKSRTRARKAQAMALPQINLDNYSVLPAGEGDEDREAEMDDEEEALG 557

  Fly   387 CML-------------ENDPNIKVSIVRCFSLMTPENQRDVFNPPPPGFRKIILTTNIAESSITV 438
            ..|             :.|.::.:.::..:||:.||.|..||.|||.|.|..::.||:||:|:|:
  Rat   558 SDLDLDLGDSEANEGEQPDASLPLHVLPLYSLLAPEKQAQVFKPPPEGTRLCVIATNVAETSLTI 622

  Fly   439 PDVSYVIDFCLAKVKVTDTASSFSSLRLTWASKANCRQRAGRVGRLRSGRVYRMVNKHFYQREMP 503
            |.:.||:|....|.:..|..:..||.|:||.|:|:..|||||.||...|..||:.:...: .:..
  Rat   623 PGIKYVVDCGKVKKRYYDRVTGVSSFRVTWVSQASADQRAGRAGRTEPGHCYRLYSSAVF-GDFE 686

  Fly   504 EFGIPEMLRLPLQNSVLKAKVLNMGSPVEILALALSPPNLSDIHNTILLLKEVGALY-------- 560
            :|..||:.|.|:::.:|:.|.||:...:..  ...:||::..:.....||..:|||.
  Rat   687 QFPPPEITRRPVEDLILQMKALNIEKVINF--PFPTPPSVEALIAAEELLIALGALQAPPKQERM 749

  Fly   561 --LTVDGIYDPLDGDLTYWGTIMSRLPLDTRQSRLIILGYIFNMLEEAIIIAAGLSTPGLFAH-- 621
              |.:..:..|    :|..|..||..|:..|.::::.|......|...|.|.|.::...||..
  Rat   750 KKLQMSQLSCP----ITALGRTMSTFPVAPRYAKMLALSQQHGCLPYTIAIVAAMTVRELFEELD 810

  Fly   622 ------------EGGRSQLGD--SFWMHYIFSDGSGSDL-VAIWRVYLTYLNIVENG-----HDQ 666
                        :|.|:::..  ..|.      |.|:.| :....|.|..:...|..     ..|
  Rat   811 RPAASEEELAELKGRRTRVAQMKRTWA------GQGASLKLGDLMVLLGAVGACEYAGCSPQFCQ 869

  Fly   667 ESAIRWAKRFHVSLRSLKEIHLLVQELRVR----CTHLGLIPFPVNPNQMMDDREKAIMLKVIIA 727
            .:.:|:        :::.||..|..:|...    |...||.   ::|........:...|:.|:|
  Rat   870 ANGLRY--------KAMLEIRRLRGQLTTAVNAVCPEAGLF---LDPKMQPPTESQVTYLRQIMA 923

  Fly   728 GAFYPNYFTR-SKESCADTD-RNIYQTISGHDPCRTVYFTNFKPAYMGELYTRRIKELFQEVRIP 790
            .....:...| ..|...|.. :|.|:|....||                ::......||:|:
  Rat   924 AGLGDHLARRVQSEDLLDPKWKNAYKTPLLDDP----------------VFIHPSSVLFREL--- 969

  Fly   791 PENMDVTFQE--GSQKVF---VTFKQDDWI---------------EGSSKYVPVSGRV 828
            ||  .|.:||  .:.|::   |:..:..||               |.:..|.|.||||
  Rat   970 PE--FVVYQEIVETTKMYMKGVSTVEIQWIPSLLPSYCQFDAPLEEPAPTYCPESGRV 1025

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spn-E	NP_476741.1	HrpA	113..>697	CDD:224557	182/683 (27%)
spn-E	NP_476741.1	TUDOR	892..1016	CDD:395449
Dhx37	NP_001099396.2	HrpA	236..1009	CDD:224557	209/820 (25%)
		DEXDc	267..407	CDD:238005	57/142 (40%)
		HELICc	578..667	CDD:197757	36/88 (41%)
		HA2	730..781	CDD:282288	13/54 (24%)
		HA2	761..852	CDD:214852	20/96 (21%)
		OB_NTP_bind	887..1004	CDD:285018	28/140 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900