DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spn-E and Dhx40

DIOPT Version :9

Sequence 1:	NP_476741.1	Gene:	spn-E / 41919	FlyBaseID:	FBgn0003483	Length:	1434	Species:	Drosophila melanogaster
Sequence 2:	NP_001005873.1	Gene:	Dhx40 / 287595	RGDID:	1359618	Length:	779	Species:	Rattus norvegicus

Alignment Length:	714	Identity:	188/714 - (26%)
Similarity:	310/714 - (43%)	Gaps:	145/714 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 LLNEQPQGKRIRTLDDLD-TDDEGEETEIRRDDEYYKKFRFNLNRDKNLSIYAKREEILAAINAH 131
            |..|:|...||...::.. |..||..|                   ....|..:|::::.|:..:
  Rat    24 LQEERPSAVRIADREEKGCTSQEGGTT-------------------PTFPIQKQRKKLIQAVRDN 69

  Fly   132 PVVIIKGETGCGKTTQVPQYILDEAYKSG--KYCNIVVTQPRRIAAISIANRVCQEREWQQNTVC 194
            ..:|:.|.||.|||||:|:|:    |::|  ::..|.|||||::||||:|.||.:|.:....:..
  Rat    70 SFLIVTGNTGSGKTTQLPKYL----YEAGFSQHGMIGVTQPRKVAAISVAQRVAEEMKCTLGSKV 130

  Fly   195 SFQVGLHRPNSLEDTRLLYCTTGVLLNNLINNKTLTHYTHIVLDEVHERDQNMDFLLIVVRRLLA 259
            .:||.....:| ::|.:.|.|.|.||.:::.:..|..::.|:|||.|||....|.|..::::|..
  Rat   131 GYQVRFDDCSS-KETAIKYMTDGCLLKHILGDPNLNKFSVIILDEAHERTLTTDILFGLLKKLFQ 194

  Fly   260 TNS----RHVKIILMSATIDAKELSDYFTTTNSIPPVITTNHRRKHSIEKFY-----RDQLGSII 315
            ..|    .|:|:::||||::..:||.:|...    |:.....|.....|||.     ||:
  Rat   195 DKSPNRKEHLKVVVMSATMELAKLSAFFGNC----PIFDIPGRLYPVREKFCNLIGPRDR----- 250

  Fly   316 WNEEDVGHQQVPEINKHGYRAAVKIIVIIDNMERKAAIQSRQSYDEALRYGAVLIFLPGIYEIDT 380
               |:..:.|          |.||:.:.|...|..               |.:|:||.|.:||:.
  Rat   251 ---ENTAYIQ----------AIVKVTMDIHLNEMA---------------GDILVFLTGQFEIEK 287

  Fly   381 MAENLTCMLEN---DPNIK------VSIVRCFSLMTPENQRDVFNPPPPGFRKIILTTNIAESSI 436
            ..|.|..|.|:   |.:::      :.|:.|:..||.:.||.:|.|||||.||.:::|||:.:|:
  Rat   288 SCELLFQMAESVDYDYDVQDTTLDGLLILPCYGSMTTDQQRRIFLPPPPGIRKCVISTNISATSL 352

  Fly   437 TVPDVSYVIDFCLAKVKVTDTASSFSSLRLTWASKANCRQRAGRVGRLRSGRVYRMVNKHFYQRE 501
            |:..:.||:|....|....:.......|.:...||:...||:||.||..||:.:|:.:|.|:.:.
  Rat   353 TIDGIRYVVDGGFVKQLNHNPRLGLDILEVVPISKSEALQRSGRAGRTASGKCFRIYSKDFWNQC 417

  Fly   502 MPEFGIPEMLRLPLQNSVLKAKVLNMGSPVEILALALSPPNLSDIHNTILLLKEVGALYLTVDGI 566
            ||:..|||:.|..|.:.||..|.|.:...:..  ..|.||      |..|:|:.:..||..
  Rat   418 MPDHVIPEIKRTSLTSVVLTLKCLAIHDVIRF--PYLDPP------NERLILEALKQLYQC---- 470

  Fly   567 YDPLD--GDLTYWGTIMSRLPLDTRQSRLIILGYIFNMLEEAIIIAAGLSTPGLF---------- 619
             |.:|  |.:|..|..|...||....:..:|.....:..:..:.|||.||...:|
  Rat   471 -DAIDRSGHVTRLGLSMVEFPLPPHLTCAVIRAASLDCEDLLLPIAAMLSVENVFIRPVDPEYQK 534

  Fly   620 ----------AHEGGRSQLGDSFWMHYIFSDGSGSDLVAIWRVYLTYLNIVENGHDQESAIRWAK 674
                      |..||   ..|...:..||.....|...|.|              .|:..|.|..
  Rat   535 EAEQKHRELAAKAGG---FNDFATLAVIFEQCKSSGAPASW--------------CQKHWIHWRC 582

  Fly   675 RFHVSLRSLKEIHLLVQELRVRCTHLGLIPFPVNPNQMMDDREKAIMLKVIIAGAFYPNYFTRS 738
            .|. :.|...::..|:::|:.:...         |.:..:..:..::.:.:.|| ::.|...||
  Rat   583 LFS-AFRVEAQLRELIRKLKQQSDF---------PRETFEGPKHEVLRRCLCAG-YFKNVARRS 635

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spn-E	NP_476741.1	HrpA	113..>697	CDD:224557	173/625 (28%)
spn-E	NP_476741.1	TUDOR	892..1016	CDD:395449
Dhx40	NP_001005873.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..53		9/47 (19%)
		HrpA	51..750	CDD:224557	179/668 (27%)
		DEAH box	173..176		2/2 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810