DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spn-E and Ythdc2

DIOPT Version :9

Sequence 1:	NP_476741.1	Gene:	spn-E / 41919	FlyBaseID:	FBgn0003483	Length:	1434	Species:	Drosophila melanogaster
Sequence 2:	NP_001156485.1	Gene:	Ythdc2 / 240255	MGIID:	2448561	Length:	1445	Species:	Mus musculus

Alignment Length:	1127	Identity:	272/1127 - (24%)
Similarity:	423/1127 - (37%)	Gaps:	371/1127 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 EVPNRELIGTDYVSKIVAKEKCLLNGTLLNEQPQGKRIRTLDDLDTDDEGEETEIRRDDEYYKKF 105
            |..|||:..|              :|.|.|..||                  ..::|.:..:..|
Mouse   172 EAENREMSKT--------------SGRLNNGIPQ------------------VPVKRGESEFDSF 204

  Fly   106 RFNLNRDKNLSIYAKREEILAAINAHPVVIIKGETGCGKTTQVPQYILDEAYKSGKYCNIVVTQP 170
            |      ::|.::.|:|||:..|..:.||:|.||||.|||||:||::||:.:|:|..|.|..|||
Mouse   205 R------QSLPVFEKQEEIVKIIKENKVVLIVGETGSGKTTQIPQFLLDDCFKNGIPCRIFCTQP 263

  Fly   171 RRIAAISIANRVCQEREWQQNTVCSFQVGLHRPNSLEDTRLLYCTTGVLLNNLI-NNKTLTHYTH 234
            ||:|||::|.||..||..:......:|:.|....| ..|.|.:||.||||..|: .:.||:..||
Mouse   264 RRLAAIAVAERVAAERRERIGQTIGYQIRLESRVS-PKTLLTFCTNGVLLRTLMAGDSTLSTVTH 327

  Fly   235 IVLDEVHERDQNMDFLLIVVRRLLATNSRH--VKIILMSATIDAKELSDYFTTTNSIPPVI---- 293
            :::|||||||:..||||..:|.||   .:|  :|:||.||.:|......||.:.    |||
Mouse   328 VIVDEVHERDRFSDFLLTKLRDLL---QKHPTLKLILSSAALDVNLFIRYFGSC----PVIYIQG 385

  Fly   294 ---------------TTNHRRKH----------------------------------------SI 303
                           ||.:..|.                                        |:
Mouse   386 RPFEVKEMFLEDILRTTGYTNKEMLKYKKEKQREEKQQTTLTEWYSAQENTFKPESQRQRAVASV 450

  Fly   304 EKFY-----------------------------RDQLGSIIWNEEDVG------H----QQVPEI 329
            .:.|                             .|...|.||..:||.      |    :.|...
Mouse   451 SEEYDLLDDGGDAVFSQLTEKDVNCLEPWLIKEMDACLSDIWLHKDVDAFAQVFHLILTENVSVD 515

  Fly   330 NKHGYRAAVKIIV-----------------------------------------IID-------- 345
            .:|...:|..::|                                         |:|
Mouse   516 YRHSETSATALMVAAGRGFTSQVEQLISMGANVHSKASNGWMALDWAKHFGQTEIVDLLESYSAS 580

  Fly   346 ----NMERKAAIQS----------------RQSYDEA---------LRY--------GAVLIFLP 373
                |::..:.:|:                ..|:|:.         |.|        ||:|||||
Mouse   581 LEFGNLDESSLVQTNGNDLSAEDRELLKAYHHSFDDEKVDLDLIMHLLYNICHSCDAGAILIFLP 645

  Fly   374 GIYEIDTMAENLTCMLEN----DPNIKVSIVRCFSLMTPENQRDVFNPPPPGFRKIILTTNIAES 434
            |..||..:.:.:  :.::    |...:..:....|.|...:|:.|...||.|.|||||:|||||:
Mouse   646 GYDEIVGLRDRI--LFDDKRFADNTHRYQVFMLHSNMQTSDQKKVLKNPPAGVRKIILSTNIAET 708

  Fly   435 SITVPDVSYVIDFCLAKVKVTDTASSFSSLRLTWASKANCRQRAGRVGRLRSGRVYRMVNKHFYQ 499
            ||||.||.:|||....|.|..|..:..:.|::.|.|||:..||.||.||.|.|..:|:.::..:|
Mouse   709 SITVNDVVFVIDSGKVKEKSFDALNFVTMLKMVWISKASAIQRKGRAGRCRPGICFRLFSRLRFQ 773

  Fly   500 REMPEFGIPEMLRLPLQNSVLKAKVLNMGSPV-----EILALALSPPNLSDIHNTILLLKEVGAL 559
             .|.||..||:||:|||...|..|:|   :||     :.|..|..||....:.|.:.:||.:
Mouse   774 -NMLEFQTPELLRMPLQELCLHTKLL---APVNCTIADFLMKAPEPPPALIVRNAVQMLKTI--- 831

  Fly   560 YLTVDGIYDPLDG--DLTYWGTIMSRLPLDTRQSRLIILGYIFNMLEEAIIIAAGLSTPGLFAHE 622
                    |.:|.  |||..|..::.||::....::::...:...|:..:.||..|:....|...
Mouse   832 --------DAMDAWEDLTELGYHLADLPVEPHLGKMVLCAVVLKCLDPILTIACTLAYRDPFVLP 888

  Fly   623 GGRSQLGDSFWMHYIFSDGSGSDLVAIWRVYLTYLNIVENGHDQESAIRWAKRF---HVSLRSLK 684
            ...||...:......|:.|:.||.:|:.|.:..:.....:|        |.:.|   :...::..
Mouse   889 TQASQKRAAMLCRKRFTAGTFSDHMALLRAFQAWQKARSDG--------WERAFCEKNFLSQATM 945

  Fly   685 EIHL-----LVQELR----VRCTHLGLIPFPVNPNQMMDDREKAIMLKVIIAGAFYPN------- 733
            ||.:     |:.:||    ||....|.|. .||.|.     |...::|..:....|||
Mouse   946 EIIIGMRTQLLGQLRASGFVRARGGGDIR-DVNTNS-----ENWAVVKAALVAGMYPNLVHVDRE 1004

  Fly   734 --YFTRSKE-----------------------------SCADTDRNIYQTI------------SG 755
              ..|..||                             ....||..||..:            |.
Mouse  1005 NVILTGPKEKKVRFHPTSVLSQPQYKKIPPANGQAAAIQALPTDWLIYDEMTRAHRIANIRCCSA 1069

  Fly   756 HDPCRTVYFTNFKPAYMGELYTRRIKE--LFQEVRIPPENMDVTFQEGSQKVFVTFKQDDWIEGS 818
            ..|...:.|..  ||   .|.:..::|  .|:...||.::.|...::.:.......|.|:|:  :
Mouse  1070 VTPVTVLVFCG--PA---RLASNALQEPSSFRADGIPNDSSDSEMEDRTTANLAALKLDEWL--N 1127

  Fly   819 SKYVPVSG----RVQSEVYKAVMMRQNRVERP------------IHIMNPSAFMSYVQQ-RGIGD 866
            .|..|.:.    :::.:.:...:.|.....:|            |.:::.....:.:|| .|||.
Mouse  1128 FKLEPEAASLLLQLRQKWHSLFLRRMRAPSKPWSQVDEATIRAIIAVLSTEEQSAGLQQPSGIGQ 1192

  Fly   867 VIEGRWIPPTKPLNVELLALPS 888
                    ..:|::.|.|.|.|
Mouse  1193 --------RPRPMSSEELPLAS 1206

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spn-E	NP_476741.1	HrpA	113..>697	CDD:224557	212/793 (27%)
spn-E	NP_476741.1	TUDOR	892..1016	CDD:395449
Ythdc2	NP_001156485.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..50
		R3H_DEXH_helicase	61..119	CDD:100077
		DEXDc	225..364	CDD:238005	67/142 (47%)
		DEAH box	331..334		2/2 (100%)
		ANK	502..587	CDD:238125	8/84 (10%)
		ANK repeat	520..552	CDD:293786	2/31 (6%)
		ANK 1	521..553		2/31 (6%)
		Ank_4	524..574	CDD:290365	3/49 (6%)
		ANK 2	554..586		2/31 (6%)
		ANK repeat	554..582	CDD:293786	2/27 (7%)
		Helicase_C	625..757	CDD:278689	51/133 (38%)
		HA2	831..916	CDD:214852	20/95 (21%)
		OB_NTP_bind	954..1081	CDD:285018	25/134 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1179..1303		10/36 (28%)
		YTH	1304..1434	CDD:282058
		N6-methyladenosine binding. /evidence=ECO:0000250\|UniProtKB:Q9Y5A9	1309..1311
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D278674at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820