DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spn-E and DHX30

DIOPT Version :9

Sequence 1:	NP_476741.1	Gene:	spn-E / 41919	FlyBaseID:	FBgn0003483	Length:	1434	Species:	Drosophila melanogaster
Sequence 2:	XP_011531792.1	Gene:	DHX30 / 22907	HGNCID:	16716	Length:	1265	Species:	Homo sapiens

Alignment Length:	943	Identity:	257/943 - (27%)
Similarity:	407/943 - (43%)	Gaps:	214/943 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 SKIVAKEKCLLNGTLLNEQPQGKRIRTLDDLDTDD------EGEETEI--------RRDDEYYKK 104
            |..:|.|..|.:..:|   |.||....|.|..|..      |.||..:        ||....:::
Human   440 SSWIAPELRLQSDDIL---PLGKDSGPLSDPITGKPYVPLLEAEEVRLSQSLLELWRRRGPVWQE 501

  Fly   105 FRFNLNRDKNLSIYAKREEILAAINAHPVVIIKGETGCGKTTQVPQYILDEAYKSGK--YCNIVV 167
                   ...|.:...|:.||.||..||||:|.|:|||||||::||.:|:.....|:  .||:::
Human   502 -------APQLPVDPHRDTILNAIEQHPVVVISGDTGCGKTTRIPQLLLERYVTEGRGARCNVII 559

  Fly   168 TQPRRIAAISIANRVCQEREWQQNTVCSFQVGLHRPNSLEDTRLLYCTTGVLLNNLINNKTLTHY 232
            ||||||:|:|:|.||..|..........|||.|..........||:||.|:||..|.:|.:|...
Human   560 TQPRRISAVSVAQRVSHELGPSLRRNVGFQVRLESKPPSRGGALLFCTVGILLRKLQSNPSLEGV 624

  Fly   233 THIVLDEVHERDQNMDFLLIVVRRLLATNSRHVKIILMSATIDAKELSDYF--TTTNSIP----P 291
            :|:::|||||||.|.|||||:::.|...|.. ::::|||||.|.:..|.||  .....:|    |
Human   625 SHVIVDEVHERDVNTDFLLILLKGLQRLNPA-LRLVLMSATGDNERFSRYFGGCPVIKVPGFMYP 688

  Fly   292 VITTNHRRKHSIEKFYRDQLGSIIWNEEDVGHQQVPEINKHGYRAAVKIIVIIDNMERKAAIQSR 356
            |      ::|.:|.... :||.         ||.   :::|.:..:          |.:.|:...
Human   689 V------KEHYLEDILA-KLGK---------HQY---LHRHRHHES----------EDECALDLD 724

  Fly   357 QSYDEALRY------GAVLIFLPGIYEIDTMAENLTCMLENDPNIKVSIVRCFSLMTPENQRDVF 415
            ...|..|..      |.:|.||||..||..:.:.|...|....: |..|:...|.:...:|:.:|
Human   725 LVTDLVLHIDARGEPGGILCFLPGWQEIKGVQQRLQEALGMHES-KYLILPVHSNIPMMDQKAIF 788

  Fly   416 NPPPPGFRKIILTTNIAESSITVPDVSYVIDFCLAKVKVTDTASSFSSLRLTWASKANCRQRAGR 480
            ..||.|.|||:|.|||||:|||:.|:.:|:|..|.|.:..|..:..|.|...|.|:||..||.||
Human   789 QQPPVGVRKIVLATNIAETSITINDIVHVVDSGLHKEERYDLKTKVSCLETVWVSRANVIQRRGR 853

  Fly   481 VGRLRSGRVYRMVNKHFYQREMPEFGIPEMLRLPLQNSVLKAKV-LNMGSPVEILALALSPPNLS 544
            .||.:||..|.:..:...::.:| |.:||:||.||:|.||:||: :...:.||.|:.|:..||:.
Human   854 AGRCQSGFAYHLFPRSRLEKMVP-FQVPEILRTPLENLVLQAKIHMPEKTAVEFLSKAVDSPNIK 917

  Fly   545 DIHNTILLLKEVGAL----YLTVDGIYDPLDGDLTYWGTIMSRLPLDTRQSRLIILGYIFNMLEE 605
            .:...::||:|:|.|    |||.             .|..::.:..|.|.::.|:|..||..|..
Human   918 AVDEAVILLQEIGVLDQREYLTT-------------LGQRLAHISTDPRLAKAIVLAAIFRCLHP 969

  Fly   606 AIIIAAGLSTPGLFAHEGGRSQLGDSFWMHYIFSDGSGSDLVAIWRVYLTYLNIVENGHDQESAI 670
            .:::.:.|:.....:....|:::..   :..:.|..||||.:|..|....:          |..:
Human   970 LLVVVSCLTRDPFSSSLQNRAEVDK---VKALLSHDSGSDHLAFVRAVAGW----------EEVL 1021

  Fly   671 RWAKRFHVSLR------------SLKEIHLLVQELRVRCTHLGLIPFP-------VNPNQMMDDR 716
            ||..|   |.|            ||:.||.|:::.........|:..|       ...|:..::.
Human  1022 RWQDR---SSRENYLEENLLYAPSLRFIHGLIKQFSENIYEAFLVGKPSDCTLASAQCNEYSEEE 1083

  Fly   717 E--KAIML-------------KVIIAGAFYPNYFTRSKESCADTDRNIYQTISGH---------- 756
            |  |.:::             ||...|.|.||..|             |:|.||:
Human  1084 ELVKGVLMAGLYPNLIQVRQGKVTRQGKFKPNSVT-------------YRTKSGNILLHKSTINR 1135

  Fly   757 --DPCRTVYFTNFKPAYM-GELYTRRIKELFQEVRIPPENMDVTFQEGSQKVFVTFKQDDW--IE 816
              ...|:.:.|.|..... |.::.|...::.....:...:.||..::..::..::....|.  :|
Human  1136 EATRLRSRWLTYFMAVKSNGSVFVRDSSQVHPLAVLLLTDGDVHIRDDGRRATISLSDSDLLRLE 1200

  Fly   817 GSSKYVPVSGRVQSEVYKAVMMRQNRVERPIHIMNPSAFMSYVQQRGIGDVIEGRWIPPTKPLNV 881
            |.|:.|    |:..|:                            :|.:|.::|       :.|..
Human  1201 GDSRTV----RLLKEL----------------------------RRALGRMVE-------RSLRS 1226

  Fly   882 ELLAL-PSVFDKTISGSITCIV------NCGKF 907
            ||.|| |||.::  .|.:..::      .||.|
Human  1227 ELAALPPSVQEE--HGQLLALLAELLRGPCGSF 1257

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spn-E	NP_476741.1	HrpA	113..>697	CDD:224557	196/614 (32%)
spn-E	NP_476741.1	TUDOR	892..1016	CDD:395449	4/22 (18%)
DHX30	XP_011531792.1	HrpA	494..>1143	CDD:224557	214/729 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D278674at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820