DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spn-E and Dhx8

DIOPT Version :9

Sequence 1:	NP_476741.1	Gene:	spn-E / 41919	FlyBaseID:	FBgn0003483	Length:	1434	Species:	Drosophila melanogaster
Sequence 2:	NP_659080.2	Gene:	Dhx8 / 217207	MGIID:	1306823	Length:	1244	Species:	Mus musculus

Alignment Length:	935	Identity:	230/935 - (24%)
Similarity:	381/935 - (40%)	Gaps:	235/935 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 EVMDFFDFSKELKRVAAAP---QGYISSDPRLMATKFKSSEVPNRELIGTDYVSKIVAKEKCLLN 65
            :|.|..|...|::.|...|   :|:......:...|...:  |:..|.....:...:|||:
Mouse   452 KVDDEEDEDLEIELVEEEPPFLRGHTKQSMDMSPIKIVKN--PDGSLSQAAMMQSALAKER---- 510

  Fly    66 GTLLNEQPQGKRIRTLDDLD-----------TDDEGEETE--------IRRDDEYYKKFRFN--- 108
                .|..|.:|...:|.:.           .|.||.:..        :..|...:||..|.
Mouse   511 ----RELKQAQREAEMDSIPMGLNKHWVDPLPDAEGRQIAANMRGIGMMPNDIPEWKKHAFGGNK 571

  Fly   109 -----------LNRDKNLSIYAKREEILAAINAHPVVIIKGETGCGKTTQVPQYILDEAYKS-GK 161
                       |.:.::|.||..:|:::.|::.:.::|:.||||.|||||:.||:.:..|.| ||
Mouse   572 ASYGKKTQMSILEQRESLPIYKLKEQLVQAVHDNQILIVIGETGSGKTTQITQYLAEAGYTSRGK 636

  Fly   162 YCNIVVTQPRRIAAISIANRVCQEREWQQNTVCSFQVGLHRPNSLEDTRLLYCTTGVLLNNLINN 226
               |..|||||:||:|:|.||.:|..........:.:......|.| |.:.|.|.|:||...:.:
Mouse   637 ---IGCTQPRRVAAMSVAKRVSEEFGCCLGQEVGYTIRFEDCTSPE-TVIKYMTDGMLLRECLID 697

  Fly   227 KTLTHYTHIVLDEVHERDQNMDFLLIVVRRLLATNSRHVKIILMSATIDAKELSDYFTTTNSIPP 291
            ..||.|..|:|||.|||..:.|.|..::::.: ...:.:|:|:.|||:||.:.|.||...    |
Mouse   698 PDLTQYAIIMLDEAHERTIHTDVLFGLLKKTV-QKRQDMKLIVTSATLDAVKFSQYFYEA----P 757

  Fly   292 VITTNHRRKHSIEKFYRDQLGSIIWNEEDVGHQQVPEINKHGYRAAVKIIVIIDNMERKAAIQSR 356
            :.|. ..|.:.:|         |::.:|       ||.:   |..|..|.|:..::....
Mouse   758 IFTI-PGRTYPVE---------ILYTKE-------PETD---YLDASLITVMQIHLTEPP----- 797

  Fly   357 QSYDEALRYGAVLIFLPGIYEIDTMAENLTCMLEN-DPNI-KVSIVRCFSLMTPENQRDVFNPPP 419
                     |.:|:||.|..||||..|.|...::: .|:: ::.|:..:|.:..|.|..:|:|.|
Mouse   798 ---------GDILVFLTGQEEIDTACEILYERMKSLGPDVPELIILPVYSALPSEMQTRIFDPAP 853

  Fly   420 PGFRKIILTTNIAESSITVPDVSYVIDFCLAKVKVTDTASSFSSLRLTWASKANCRQRAGRVGRL 484
            ||.||:::.|||||:|:|:..:.||:|....|.||.::.:....|.:|..|:|..:|||||.||.
Mouse   854 PGSRKVVIATNIAETSLTIDGIYYVVDPGFVKQKVYNSKTGIDQLVVTPISQAQAKQRAGRAGRT 918

  Fly   485 RSGRVYRMVNKHFYQREMPEFGIPEMLRLPLQNSVLKAKVLNMGS----------PVEILALALS 539
            ..|:.||:..:..|:.||....:||:.|..|.::||..|.:.:..          |:|.|..|:.
Mouse   919 GPGKCYRLYTERAYRDEMLTTNVPEIQRTNLASTVLSLKAMGINDLLSFDFMDAPPMETLITAME 983

  Fly   540 PPNLSDIHNTILLLKEVGALYLTVDGIYDPLDGDLTYWGTIMSRLPLDTRQSRLIILGYIFNMLE 604
            .            |..:|||        |. :|.||..|..|:..||:....:::|:.......|
Mouse   984 Q------------LYTLGAL--------DD-EGLLTRLGRRMAEFPLEPMLCKMLIMSVHLGCSE 1027

  Fly   605 EAIIIAAGLSTPGLFAHEGGRSQLGDSFWMHYIFSDGSGSDLVAIWRVYLTYLNIVENGHDQESA 669
            |.:.|.:.||...:|.....:..|.|.....:..::|.          :||.|.:..:..:.:.:
Mouse  1028 EMLTIVSMLSVQNVFYRPKDKQALADQKKAKFHQTEGD----------HLTLLAVYNSWKNNKFS 1082

  Fly   670 IRWAKRFHVSLRSLKEIHLLVQELRVRCTHLGLIPFPVNPNQMMDDREKAIMLKVIIAGAFYPNY 734
            ..|.....:..|||:.    .|::|.:.  ||::           ||.|   |.|:
Mouse  1083 NPWCYENFIQARSLRR----AQDIRKQM--LGIM-----------DRHK---LDVV--------- 1118

  Fly   735 FTRSKESCADTDRNIYQTI-SGHDPCRTVYFTNFKPAYMGELYTRRIKELFQEVRIPPENMDVTF 798
                  ||..:...:.:.| ||       :|.|.......|.|...|.:  |.|.|.|
Mouse  1119 ------SCGKSTVRVQKAICSG-------FFRNAAKKDPQEGYRTLIDQ--QVVYIHP------- 1161

  Fly   799 QEGSQKVFVTFKQDDWIEGSSKYVPVSGRVQSEVYKAVMMRQNRVERPIHIMNPSAFMSYVQQRG 863
               |..:|  .:|.:|:                ||..:::......|.:..::|
Mouse  1162 ---SSALF--NRQPEWV----------------VYHELVLTTKEYMREVTTIDP----------- 1194

  Fly   864 IGDVIEGRWI-----------PPTK 877
                   ||:           .|||
Mouse  1195 -------RWLVEFAPAFFKVSDPTK 1212

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spn-E	NP_476741.1	HrpA	113..>697	CDD:224557	171/596 (29%)
spn-E	NP_476741.1	TUDOR	892..1016	CDD:395449
Dhx8	NP_659080.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	152..289
		S1_DHX8_helicase	289..367	CDD:240189
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	361..396
		DEXDc	585..770	CDD:214692	68/203 (33%)
		DEXDc	606..744	CDD:238005	53/142 (37%)
		DEAH box	709..712		2/2 (100%)
		HELICc	769..926	CDD:238034	58/189 (31%)
		HA2	988..1070	CDD:214852	23/100 (23%)
		OB_NTP_bind	1104..1203	CDD:285018	31/184 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900