Protein Alignment spn-E and Dhx8

DIOPT Version :10

• Sequence 1: NP_476741.1
• Gene: spn-E / 41919
• FlyBaseID: FBgn0003483
• Length: 1434
• Species: Drosophila melanogaster
• Sequence 2: NP_659080.2
• Gene: Dhx8 / 217207
• MGIID: 1306823
• Length: 1244
• Species: Mus musculus
• Alignment Length: 918
• Identity: 229/918 - (24%)
• Similarity: 380/918 - (41%)
• Gaps: 210/918 - (22%)

  Fly     4 EVMDFFDFSKELKRVAAAP---QGYISSDPRLMATKFKSSEVPNRELIGTDYVSKIVAKEKCLLN 65
            :|.|..|...|::.|...|   :|:......:...|...:  |:..|.....:...:|||:..|.
Mouse   452 KVDDEEDEDLEIELVEEEPPFLRGHTKQSMDMSPIKIVKN--PDGSLSQAAMMQSALAKERRELK 514

  Fly    66 GTL----LNEQPQGKRIRTLDDLDTDDEGEETE--------IRRDDEYYKKFRFN---------- 108
            ...    ::..|.|.....:|.| .|.||.:..        :..|...:||..|.
Mouse   515 QAQREAEMDSIPMGLNKHWVDPL-PDAEGRQIAANMRGIGMMPNDIPEWKKHAFGGNKASYGKKT 578

  Fly   109 ----LNRDKNLSIYAKREEILAAINAHPVVIIKGETGCGKTTQVPQYILDEAYKS-GKYCNIVVT 168
                |.:.::|.||..:|:::.|::.:.::|:.||||.|||||:.||:.:..|.| ||   |..|
Mouse   579 QMSILEQRESLPIYKLKEQLVQAVHDNQILIVIGETGSGKTTQITQYLAEAGYTSRGK---IGCT 640

  Fly   169 QPRRIAAISIANRVCQEREWQQNTVCSFQVGLHRPNSLEDTRLLYCTTGVLLNNLINNKTLTHYT 233
            ||||:||:|:|.||.:|..........:.:......|.| |.:.|.|.|:||...:.:..||.|.
Mouse   641 QPRRVAAMSVAKRVSEEFGCCLGQEVGYTIRFEDCTSPE-TVIKYMTDGMLLRECLIDPDLTQYA 704

  Fly   234 HIVLDEVHERDQNMDFLLIVVRRLLATNSRHVKIILMSATIDAKELSDYFTTTNSIPPVITTNHR 298
            .|:|||.|||..:.|.|..::::.: ...:.:|:|:.|||:||.:.|.||...    |:.|. ..
Mouse   705 IIMLDEAHERTIHTDVLFGLLKKTV-QKRQDMKLIVTSATLDAVKFSQYFYEA----PIFTI-PG 763

  Fly   299 RKHSIEKFYRDQLGSIIWNEEDVGHQQVPEINKHGYRAAVKIIVIIDNMERKAAIQSRQSYDEAL 363
            |.:.:|         |::.:|       ||.:   |..|..|.|:..::....
Mouse   764 RTYPVE---------ILYTKE-------PETD---YLDASLITVMQIHLTEPP------------ 797

  Fly   364 RYGAVLIFLPGIYEIDTMAENLTCMLEN-DPNI-KVSIVRCFSLMTPENQRDVFNPPPPGFRKII 426
              |.:|:||.|..||||..|.|...::: .|:: ::.|:..:|.:..|.|..:|:|.|||.||::
Mouse   798 --GDILVFLTGQEEIDTACEILYERMKSLGPDVPELIILPVYSALPSEMQTRIFDPAPPGSRKVV 860

  Fly   427 LTTNIAESSITVPDVSYVIDFCLAKVKVTDTASSFSSLRLTWASKANCRQRAGRVGRLRSGRVYR 491
            :.|||||:|:|:..:.||:|....|.||.::.:....|.:|..|:|..:|||||.||...|:.||
Mouse   861 IATNIAETSLTIDGIYYVVDPGFVKQKVYNSKTGIDQLVVTPISQAQAKQRAGRAGRTGPGKCYR 925

  Fly   492 MVNKHFYQREMPEFGIPEMLRLPLQNSVLKAKVLNMGS----------PVEILALALSPPNLSDI 546
            :..:..|:.||....:||:.|..|.::||..|.:.:..          |:|.|..|:..
Mouse   926 LYTERAYRDEMLTTNVPEIQRTNLASTVLSLKAMGINDLLSFDFMDAPPMETLITAMEQ------ 984

  Fly   547 HNTILLLKEVGALYLTVDGIYDPLDGDLTYWGTIMSRLPLDTRQSRLIILGYIFNMLEEAIIIAA 611
                  |..:|||        |. :|.||..|..|:..||:....:::|:.......||.:.|.:
Mouse   985 ------LYTLGAL--------DD-EGLLTRLGRRMAEFPLEPMLCKMLIMSVHLGCSEEMLTIVS 1034

  Fly   612 GLSTPGLFAHEGGRSQLGDSFWMHYIFSDGSGSDLVAIWRVYLTYLNIVENGHDQESAIRWAKRF 676
            .||...:|.....:..|.|.....:..::|.          :||.|.:..:..:.:.:..|....
Mouse  1035 MLSVQNVFYRPKDKQALADQKKAKFHQTEGD----------HLTLLAVYNSWKNNKFSNPWCYEN 1089

  Fly   677 HVSLRSLKEIHLLVQELRVRCTHLGLIPFPVNPNQMMDDREKAIMLKVIIAGAFYPNYFTRSKES 741
            .:..|||:.    .|::|.:.  ||::           ||.|   |.|:               |
Mouse  1090 FIQARSLRR----AQDIRKQM--LGIM-----------DRHK---LDVV---------------S 1119

  Fly   742 CADTDRNIYQTI-SGHDPCRTVYFTNFKPAYMGELYTRRIKELFQEVRIPPENMDVTFQEGSQKV 805
            |..:...:.:.| ||       :|.|.......|.|...|.:  |.|.|.|          |..:
Mouse  1120 CGKSTVRVQKAICSG-------FFRNAAKKDPQEGYRTLIDQ--QVVYIHP----------SSAL 1165

  Fly   806 FVTFKQDDWIEGSSKYVPVSGRVQSEVYKAVMMRQNRVERPIHIMNPSAFMSYVQQRGIGDVIEG 870
            |  .:|.:|:                ||..:::......|.:..::|
Mouse  1166 F--NRQPEWV----------------VYHELVLTTKEYMREVTTIDP------------------ 1194

  Fly   871 RWIPPTKP 878
            ||:....|
Mouse  1195 RWLVEFAP 1202

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spn-E	NP_476741.1	HrpA	114..>697	CDD:441249	171/595 (29%)
		DEXHc_TDRD9	115..295	CDD:350746	65/180 (36%)
		TUDOR	892..1016	CDD:425754
Dhx8	NP_659080.2	GH2-like_DHX8	25..92	CDD:409668
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	152..289
		S1_DHX8_helicase	289..367	CDD:240189
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	361..396
		HrpA	580..>1211	CDD:441249	204/787 (26%)
		DEAH box	709..712		2/2 (100%)