DRSC/TRiP Functional Genomics Resources

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Protein Alignment spn-E and Dhx33

DIOPT Version :10

Sequence 1:NP_476741.1 Gene:spn-E / 41919 FlyBaseID:FBgn0003483 Length:1434 Species:Drosophila melanogaster
Sequence 2:NP_848144.3 Gene:Dhx33 / 216877 MGIID:2445102 Length:698 Species:Mus musculus


Alignment Length:687 Identity:200/687 - (29%)
Similarity:317/687 - (46%) Gaps:102/687 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly   113 KNLSIYAKREEILAAINAHPVVIIKGETGCGKTTQVPQYILDEAYKSG--KYCNIVVTQPRRIAA 175
            ::|.|:..|.::||.:......::.||||.|||||:|||:    |:.|  :...|.||||||:||
Mouse    63 RSLPIFRARGQLLAQLRNLDNAVLIGETGSGKTTQIPQYL----YEGGISRQGIIAVTQPRRVAA 123

  Fly   176 ISIANRVCQEREWQQNTVCSFQVGLHRPNSLEDTRLLYCTTGVLLNNLINNKTLTHYTHIVLDEV 240
            ||:|.||..|:..:...:..:.|......| ||||:.:.|.|:||...|::..|..|:.::|||.
Mouse   124 ISLATRVSDEKRTELGKLVGYTVRFEDVTS-EDTRIKFLTDGMLLREAISDSLLRKYSCVILDEA 187

  Fly   241 HERDQNMDFLLIVV----RRLLATNSRHVKIILMSATIDAKELSDYFTTTNSIPPVITTNHRRKH 301
            |||..:.|.|..||    :|........:|:|:||||:|....|.||...    ||:.. ..|:|
Mouse   188 HERTIHTDVLFGVVKTAQKRRKELGKLPLKVIVMSATMDVDLFSQYFNRA----PVLYL-EGRQH 247

  Fly   302 SIEKFYRDQLGSIIWNEEDVGHQQVPEINKHGYRAAVKIIVIIDNMERKAAIQSRQSYDEALRYG 366
            .|:.||..|      .::|..|                          .|.:...|.:.||....
Mouse   248 PIQIFYTKQ------PQQDYLH--------------------------AALVSVFQIHQEAPASQ 280

  Fly   367 AVLIFLPGIYEIDTMAENLTC------MLENDPNIKVSIVRCFSLMTPENQRDVFNPPPPGFRKI 425
            .:|:||.|..||:.|::  ||      :.:..|::.|  :..::.:....|..||...|.|:||:
Mouse   281 DILVFLTGQEEIEAMSK--TCRDIARHLPDGCPSMLV--LPLYASLPYSQQLRVFQGAPKGYRKV 341

  Fly   426 ILTTNIAESSITVPDVSYVIDFCLAKVKVTDTASSFSSLRLTWASKANCRQRAGRVGRLRSGRVY 490
            |::|||||:|||:..:.||:|..:.|.|..:..|....|.:...||....||.||.||..||..|
Mouse   342 IISTNIAETSITITGIKYVVDTGMVKAKKYNPDSGLEVLAVQRVSKTQAWQRTGRAGREDSGICY 406

  Fly   491 RMVNKHFYQREMPEFGIPEMLRLPLQNSVLKAKVLNMGSPVEILALALSPPNLSDIHNTILLLKE 555
            |:..:..::: ..:..:||:.|..|.:.:|  ::|.|..|..:....:|.|:...|...|..|..
Mouse   407 RLYTEDEFEK-FEKMTVPEIQRCNLASVIL--QLLAMKVPNVLTFDFMSKPSPDHIEAAIAQLDL 468

  Fly   556 VGALYLTVDGIYDPLDGDLTYWGTIMSRLPLDTRQSRLIILGYIFNMLEEAIIIAAGLSTPGLFA 620
            :|||....|.:      .||..|..|:..||:.|.::.|:|...|:..||.:.|.:.||...:..
Mouse   469 LGALEHKDDQL------TLTPIGRKMAAFPLEPRFAKTILLSSKFHCTEEILTIVSLLSVDSVLY 527

  Fly   621 HEGGRSQLGDSFWMHYIFSDGSGSDLVAIWRVYLTYLNIVENGHDQESAIRWAKRFHVSLRSLKE 685
            :...|.....|....:|.|:|   |.:.:..:|.|:.||   |.:::    |.|...|:.:::  
Mouse   528 NPPARRDEVQSVRKKFISSEG---DHITLLNIYRTFKNI---GGNKD----WCKENFVNSKNM-- 580

  Fly   686 IHLLVQELRVRCTHLGL-IPFPVNPNQMMDDREKAIMLKVIIAGAFYPNYFTRSKESCADTDRNI 749
              |||.|:|.:...:.| :..|:     |..|.....::..:|.:.:.|      .:...|| ..
Mouse   581 --LLVAEVRAQLREICLKMSMPI-----MSSRGDMESVRRCMAHSLFMN------TAELQTD-GT 631

  Fly   750 YQTISGHDPC----RTVYFTNFKPA---YMGELYTRR 779
            |.|...|.|.    .:|.| :.|||   |...|||.:
Mouse   632 YATTDTHQPVAIHPSSVLF-HCKPACVVYTSLLYTNK 667

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
spn-ENP_476741.1 HrpA 114..>697 CDD:441249 179/594 (30%)
DEXHc_TDRD9 115..295 CDD:350746 70/185 (38%)
TUDOR 892..1016 CDD:425754
Dhx33NP_848144.3 Required for nucleolar location. /evidence=ECO:0000250|UniProtKB:Q9H6R0 1..71 2/7 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..20
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 29..50
HrpA 64..>534 CDD:441249 161/524 (31%)
DEAH box 185..188 2/2 (100%)
HA2, required for interaction with EIF3G and RPL26. /evidence=ECO:0000250|UniProtKB:Q9H6R0 462..553 27/99 (27%)
Critical for rDNA-binding 536..550 4/16 (25%)
OB_NTP_bind 611..688 CDD:400182 17/65 (26%)
Blue background indicates that the domain is not in the aligned region.

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