DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spn-E and mog-1

DIOPT Version :9

Sequence 1:	NP_476741.1	Gene:	spn-E / 41919	FlyBaseID:	FBgn0003483	Length:	1434	Species:	Drosophila melanogaster
Sequence 2:	NP_499212.1	Gene:	mog-1 / 176409	WormBaseID:	WBGene00003389	Length:	1131	Species:	Caenorhabditis elegans

Alignment Length:	917	Identity:	233/917 - (25%)
Similarity:	389/917 - (42%)	Gaps:	191/917 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDQEVMDFFDFSKELKRVAAAPQGYISS--DPRLMATK--------------------------F 37
            |..|:...|:...:..||....|..:..  |.|::.||                          .
Worm   298 MADELSSIFEDETDENRVTILVQNIVPPFLDGRIVFTKQAQPIIPVVDTTCDMAVSAARGSVAVR 362

  Fly    38 KSSEVPNR--------ELIGTDYVSKIVAKEKCLLNGTLLNEQPQGKRIRTLDDLDTDDEGEETE 94
            |..||.:|        ||.|:...:.:..||               |:..|.|..| ||.|...|
Worm   363 KRREVEDRKKAQDKHWELAGSKLGNLMGVKE---------------KKDETADPED-DDSGNYKE 411

  Fly    95 IR------RDDEYYKKFRFNLN---RDKNLSIYAKREEILAAINAHPVVIIKGETGCGKTTQVPQ 150
            ..      :|:|....|....:   :.:.|.::|.|::::..|..:.||||.||||.|||||:.|
Worm   412 SHQFASHMKDNEAVSDFAMEKSIKQQREYLPVFACRQKMMNVIRENNVVIIVGETGSGKTTQLAQ 476

  Fly   151 YILDEAYKSGKYCNIVVTQPRRIAAISIANRVCQEREWQQNTVCSFQVGLHRPNSLEDTRLLYCT 215
            |:|::.:  |....|..|||||:||:|:|.||..|..........:.:......| |.|.:.|.|
Worm   477 YLLEDGF--GDSGLIGCTQPRRVAAMSVARRVADEMGVDLGQDVGYAIRFEDCTS-EKTIIKYMT 538

  Fly   216 TGVLLNNLINNKTLTHYTHIVLDEVHERDQNMDFLLIVVRRLLATNSRHVKIILMSATIDAKELS 280
            .|:||...:.:.:|..|:.|::||.|||..|.|.|..::|.::|..: .:|:|:.|||:||.:.:
Worm   539 DGILLRECLGDGSLDQYSAIIMDEAHERSLNTDVLFGLLREVIAKRA-DLKLIVTSATMDADKFA 602

  Fly   281 DYF---TTTNSIPPVITTNHRRKHSIEKFYRDQLGSIIWNEEDVGHQQVPEINKHGYRAAVK--I 340
            |:|   ..|.:||       .|...:|.|                |.:.|.  :....||||  :
Worm   603 DFFGGNCPTFTIP-------GRTFPVELF----------------HARTPV--EDYVDAAVKQAV 642

  Fly   341 IVIIDNMERKAAIQSRQSYDEALRYGAVLIFLPGIYEIDTMAENLTCML-ENDPNIKVSIVRCFS 404
            .:.:..|:                 |.:|||:||..:|:...|.:...| |.|....::::..:|
Worm   643 TIHLGGMD-----------------GDILIFMPGQEDIECTCEMIKEKLGELDEAPPLAVLPIYS 690

  Fly   405 LMTPENQRDVFNPPPPGFRKIILTTNIAESSITVPDVSYVID--FCLAKVKVTDTASSFSSLRLT 467
            .:..:.|..:|...|.|.||.|:.|||||:|:||..:.:|||  ||  |:||.:......:|.:.
Worm   691 QLPSDLQAKIFQRAPGGMRKAIVATNIAETSLTVDGILFVIDPGFC--KMKVYNPRIGMDALSIF 753

  Fly   468 WASKANCRQRAGRVGRLRSGRVYRMVNKHFYQREMPEFGIPEMLRLPLQNSVLKAKVLNMGSPVE 532
            ..|:|:..||.||.||...|:.||:..:..::.|:.:..:||:.|..|.|.||..|.|.:...::
Worm   754 PVSQASANQRTGRAGRTGPGQCYRLYTERQFKDELLKSTVPEIQRTNLANVVLLLKSLGVDDLLK 818

  Fly   533 ILALALSPPNLSDIHNTILLLKEVGALYLTVDGIYDPLDGDLTYWGTIMSRLPLDTRQSRLIILG 597
            ...:. :||. .::.|::..|..:|||..|         |.||..|..|...|||...|:::|:.
Worm   819 FHFMD-APPQ-DNMLNSMYQLWTLGALDNT---------GQLTPMGRKMVEFPLDPTLSKMLIMS 872

  Fly   598 YIFNMLEEAIIIAAGLSTPGLFAHEGGRSQLGDSFWMHYIFSDGSGSDLVAIWRVYLTYLNIVEN 662
            ......:|.:.|.:.||.|.:|....||.:..|:....:...:   ||       :||:||:...
Worm   873 AEMGCSDEVLTIVSMLSVPAIFFRPKGREEEADAKKEKFQVPE---SD-------HLTFLNVYIQ 927

  Fly   663 GHDQESAIRWAKRFHVSLRSLKEIHLLVQELRVRCTHLGLIPFPVNPNQMMDDREKAI------- 720
            ....:.:.:|....::.:::||:    |:|:|.:.            .::|.|.:..:
Worm   928 WRTHKYSAKWCADNYLHVKALKK----VREVRAQL------------KEIMQDLKLPLISNGSEW 976

  Fly   721 -MLKVIIAGAFYPNYFTRSKESCADTDRNI--YQTISGHDPC-----RTVYFTNFKPAYMGELYT 777
             :::..|..|::.|         |...:.|  |..:....||     ..::...|.|.|:  :|.
Worm   977 DIVRKCICSAYFHN---------AARLKGIGEYVNVRTGIPCFLHPTSALFGMGFMPDYV--VYH 1030

  Fly   778 RRI---KELFQEVRIPPENMDVTFQEGSQKVFVTFKQDDWIEGSSKYVPVSGRVQSEVYKAVMMR 839
            ..|   ||..|.|..    :|..:......:|.:.|:.   :.|.|.:.:......|..:|.|..
Worm  1031 ELIMTAKEYMQCVTA----VDAIWLAELGPMFYSIKES---KQSRKELKMESVRTVETMEAEMRE 1088

  Fly   840 -QNRVER 845
             |..:||
Worm  1089 AQKEMER 1095

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spn-E	NP_476741.1	HrpA	113..>697	CDD:224557	173/591 (29%)
spn-E	NP_476741.1	TUDOR	892..1016	CDD:395449
mog-1	NP_499212.1	DUF1777	114..>239	CDD:285811
		DEXDc	437..620	CDD:214692	68/193 (35%)
		DEXDc	458..596	CDD:238005	55/141 (39%)
		HELICc	622..778	CDD:238034	55/192 (29%)
		HA2	840..922	CDD:214852	27/100 (27%)
		OB_NTP_bind	956..1056	CDD:285018	20/126 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810