DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spn-E and ddx-15

DIOPT Version :9

Sequence 1:	NP_476741.1	Gene:	spn-E / 41919	FlyBaseID:	FBgn0003483	Length:	1434	Species:	Drosophila melanogaster
Sequence 2:	NP_741147.1	Gene:	ddx-15 / 175771	WormBaseID:	WBGene00018967	Length:	739	Species:	Caenorhabditis elegans

Alignment Length:	744	Identity:	193/744 - (25%)
Similarity:	320/744 - (43%)	Gaps:	152/744 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   115 LSIYAKREEILAAINAHPVVIIKGETGCGKTTQVPQYILD------EAYKSGKYCNIVVTQPRRI 173
            |.::..:|:.:..:..:..:.:.||||.|||||:||:.::      :....|:...:..|||||:
Worm    76 LPVWEYKEKFMELLRNNQCITLVGETGSGKTTQIPQWAVEFMKQQQQGQPPGQARLVACTQPRRV 140

  Fly   174 AAISIANRVCQEREWQQNTVCSFQVGLHRPNSL-------EDTRLLYCTTGVLLNNLINNKTLTH 231
            ||:|:|.||.:|    .:.|...:||.    |:       |.|.|.|||.|:||...:|:..|..
Worm   141 AAMSVATRVAEE----MDVVLGQEVGY----SIRFEDCISERTVLKYCTDGMLLREAMNSPLLDK 197

  Fly   232 YTHIVLDEVHERDQNMDFLLIVVRRLLATNSRHVKIILMSATIDAKELSDYFTTTN--SIPPVIT 294
            |..::|||.|||....|.|:.:::.:: .|...:|:::||||:||.:...||....  |:|
Worm   198 YKVLILDEAHERTLATDILMGLIKEIV-RNRADIKVVIMSATLDAGKFQRYFEDCPLLSVP---- 257

  Fly   295 TNHRRKHSIEKFYRDQLGSIIWNEEDVGHQQVPEINKHGYRAAVKIIVIIDNMERKAAIQSRQSY 359
               .|...:|.|:                  .|...|....||::.::.|..:|...
Worm   258 ---GRTFPVEIFF------------------TPNAEKDYLEAAIRTVIQIHMVEEVE-------- 293

  Fly   360 DEALRYGAVLIFLPGIYEIDTMAENLTCMLENDPNIK--------VSIVRCFSLMTPENQRDVFN 416
                  |.:|:||.|..||:...:.:      |..|:        :|.:..:|.:.|..|:.:|.
Worm   294 ------GDILLFLTGQEEIEEACKRI------DREIQALGADAGALSCIPLYSTLPPAAQQRIFE 346

  Fly   417 PPPPG------FRKIILTTNIAESSITVPDVSYVIDFCLAKVKVTDTASSFSSLRLTWASKANCR 475
            |.||.      .||.:::|||||:|:|:..|.:|||...:|.||.:......||.:...|||:..
Worm   347 PAPPNRPNGAISRKCVISTNIAETSLTIDGVVFVIDPGFSKQKVYNPRIRVESLLVCPISKASAM 411

  Fly   476 QRAGRVGRLRSGRVYRMVNKHFYQREMPEFGIPEMLRLPLQNSVLKAKVLNMGSPVEILALALSP 540
            |||||.||.:.|:.:|:..:..|..||.:...||:||..|.:.||:.|  .:|:...:....:.|
Worm   412 QRAGRAGRTKPGKCFRLYTETAYGSEMQDQTYPEILRSNLGSVVLQLK--KLGTEDLVHFDFMDP 474

  Fly   541 PNLSDIHNTILLLKEVGALYLTVDGIYDPLDGDLTYWGTIMSRLPLDTRQSRLIILGYIFNMLEE 605
            |....:...:.||.     ||  ..|.|  ||:||..|::|:..|||.:.::::|.....|...|
Worm   475 PAPETLMRALELLN-----YL--QAIND--DGELTELGSLMAEFPLDPQLAKMLITSTELNCSNE 530

  Fly   606 AIIIAAGLSTPGLFAHEGGRSQLGDSFWMHYIFSDGSGSDLVAIWRVYLTYLNIVENGHDQESAI 670
            .:.|.|.||.|..:..........|.....:...||.          :||.||:..:....:...
Worm   531 ILSITAMLSVPQCWVRPNEMRTEADEAKARFAHIDGD----------HLTLLNVYHSFKQNQEDP 585

  Fly   671 RWAKRFHVSLRSLKEIHLLVQELRVRCTHLGLIPFPVNPNQMMDD---REKAIML-KVIIAGAFY 731
            :|.....::.|::|...      .|| |.|..:....|..::..|   |:..:.: |.::||.|.
Worm   586 QWCYDNFINYRTMKTAD------TVR-TQLSRVMDKYNLRRVSTDFKSRDYYLNIRKALVAGFFM 643

  Fly   732 P-NYFTRSKESCADTDRNIY----QTISGHDP---------------CRTVYFTNFKPAYMGELY 776
            . .:..||.......|..:.    .|:..|.|               .|||  |:.:|.::
Worm   644 QVAHLERSGHYVTVKDNQLVNLHPSTVLDHKPEWALYNEFVLTTKNFIRTV--TDVRPEWL---- 702

  Fly   777 TRRIKELFQEVRIPPENMDV-TFQEGSQK 804
                      ::|.|:..|: .|.:|..|
Worm   703 ----------LQIAPQYYDLDNFPDGDTK 721

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spn-E	NP_476741.1	HrpA	113..>697	CDD:224557	166/610 (27%)
spn-E	NP_476741.1	TUDOR	892..1016	CDD:395449
ddx-15	NP_741147.1	Motor_domain	41..>106	CDD:277568	7/29 (24%)
		DEXDc	70..266	CDD:214692	64/205 (31%)
		DEXDc	95..239	CDD:238005	53/152 (35%)
		HELICc	327..419	CDD:197757	34/91 (37%)
		HA2	489..572	CDD:214852	26/96 (27%)
		OB_NTP_bind	607..709	CDD:285018	21/117 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910