DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spn-E and ddx-35

DIOPT Version :9

Sequence 1:	NP_476741.1	Gene:	spn-E / 41919	FlyBaseID:	FBgn0003483	Length:	1434	Species:	Drosophila melanogaster
Sequence 2:	NP_497420.1	Gene:	ddx-35 / 175308	WormBaseID:	WBGene00022056	Length:	732	Species:	Caenorhabditis elegans

Alignment Length:	756	Identity:	195/756 - (25%)
Similarity:	336/756 - (44%)	Gaps:	146/756 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 DDLDTDDEGE----ETEIRRDDEYYKKFRFNLNRDKNLSIYAKREEILAAINAHPVVIIKGETGC 142
            ::..|::.|.    |.:::..:..|........|.: |.|:..|..||.....:..:||.|||||
Worm    41 EERSTENAGAAPPIEEQLKVHNNPYASLNIQQQRIR-LPIFKNRGHILYMCERYRTIIIVGETGC 104

  Fly   143 GKTTQVPQYILDEAYKS-GKYCNIVVTQPRRIAAISIANRVCQEREWQQNTVCSFQVGL---HRP 203
            ||:|||||::|:..:.: |:  .||:|||||:|.:::|.||.:|::    .:....||.   ...
Worm   105 GKSTQVPQFLLEAGWAADGR--QIVITQPRRVAVVTLATRVAEEKD----CILGHDVGYTVRFDD 163

  Fly   204 NSLEDTRLLYCTTGVLLNNLINNKTLTHYTHIVLDEVHERDQNMDFLLIVVRRLLATNSRHVKII 268
            .|.:||::.:.|.|:||..::.:..|:.|:.|::||.|||..|.|.||.::|:::...: .::||
Worm   164 VSDKDTKVKFMTDGLLLREILADPLLSKYSIIMIDEAHERSCNTDILLGLLRKIIQIRN-DLRII 227

  Fly   269 LMSATIDAKELSDYF---TTTNS-------------IPPVITTNHRRKHSIEKFYRDQLGSIIWN 317
            :.|||:||:...|:|   .|.||             ..||..  |..|.|:..:.:..:.::|
Worm   228 VSSATLDAELFKDFFEMNETGNSDKDTAGIISVEGRTHPVAV--HHTKTSVPDYCQSAVDTVI-- 288

  Fly   318 EEDVGHQQVPEINKHGYRAAVKIIVIIDNMERKAAIQSRQSYDEALRYGAVLIFLPGIYEIDTMA 382
                      .|:||            :|.                  |.:|:||.|..|::.:.
Worm   289 ----------NIHKH------------ENP------------------GDILVFLTGQDEVEDVC 313

  Fly   383 ENLTCMLENDPNI-KVSIVRCFSLMTPENQRDVFNPPPPGFRKIILTTNIAESSITVPDVSYVID 446
            |.|..:..|..|. ::.:|.|:..:....|...|:..|.|.||:::.|||||:|||:|.:.||||
Worm   314 EKLRELAGNLKNCDRLWVVPCYGALPAREQMKAFDSTPHGTRKVVVATNIAEASITIPGICYVID 378

  Fly   447 FCLAKVKVTDTASSFSSLRLTWASKANCRQRAGRVGRLRSGRVYRMVNKHFYQREMPEFGIPEML 511
            ....|::....|:...:|.....|||:..|||||.||:|.|:.||:..:..::| ..|..:||:.
Worm   379 TGYVKLRAQHAANGVETLMRVTVSKASAEQRAGRAGRIRPGKCYRLYPESEFER-FAEGTVPEIQ 442

  Fly   512 RLPLQNSVLKAKVLNMGSPVEILALALSPPNLSDIHNTILLLKEVGALYLTVDGIYDPLDGDLTY 576
            |..:.:::|:.|.|.:.:....  ..||||....:.|.:.||..:||:..| ..:..||
Worm   443 RCQMASTILQLKALGVQNVHRF--HYLSPPPSWAMINGLELLYALGAIDET-SQLTSPL------ 498

  Fly   577 WGTIMSRLPLDTRQSRLIILGYIFNMLEEAIIIAAGLSTPGLFAHEGGRSQLGDSFWMHYIFSDG 641
             |..|:..||....|:.::....|....|.:.|.|.:....:|.....:....|.....:...:|
Worm   499 -GLQMAEFPLPPMHSKCLLKSAEFGCSTEMVTIVAMMQIQDVFITPYRQRHQADVIRKKFAVEEG 562

  Fly   642 SGSDLVAIWRVYLTYLNI----VENGHDQESAIRWAKRFHVSLRSL-------KEIHLLVQELRV 695
            .          ::|.||:    ||||..:    :|.....|:.|.|       .::..|::...:
Worm   563 D----------HMTMLNVFTKFVENGRSK----KWCSDHFVNYRGLMRADNVRSQLVRLLKRFEI 613

  Fly   696 -RCTHLGLIPFPVNPNQMMDDREKAIMLKVIIAGAF-------YPNYFTRSKESCADTDRNIYQT 752
             :.:..|||....|..|            .::.|.|       |...:...|||   ...|:|:.
Worm   614 EKVSSRGLINCSENIRQ------------CLVTGFFSQAAQYHYTGKYMTVKES---FPFNMYKG 663

  Fly   753 ISGHDPCRTVYFTNFKPAYMGELYTRRIKELFQEVR-IPPE 792
            .|       :.|....|.::  ::|..:::..::|. |.||
Worm   664 SS-------IMFKKDYPKWV--IFTEVMQDSIRDVTVIEPE 695

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spn-E	NP_476741.1	HrpA	113..>697	CDD:224557	169/616 (27%)
spn-E	NP_476741.1	TUDOR	892..1016	CDD:395449
ddx-35	NP_497420.1	HrpA	70..702	CDD:224557	191/727 (26%)
		DEXDc	96..233	CDD:238005	54/143 (38%)
		Helicase_C	284..416	CDD:278689	48/173 (28%)
		HA2	484..568	CDD:214852	18/101 (18%)
		OB_NTP_bind	602..704	CDD:285018	22/118 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810