Protein Alignment spn-E and ddx-35

DIOPT Version :10

• Sequence 1: NP_476741.1
• Gene: spn-E / 41919
• FlyBaseID: FBgn0003483
• Length: 1434
• Species: Drosophila melanogaster
• Sequence 2: NP_497420.1
• Gene: ddx-35 / 175308
• WormBaseID: WBGene00022056
• Length: 732
• Species: Caenorhabditis elegans
• Alignment Length: 756
• Identity: 195/756 - (25%)
• Similarity: 336/756 - (44%)
• Gaps: 146/756 - (19%)

  Fly    82 DDLDTDDEGE----ETEIRRDDEYYKKFRFNLNRDKNLSIYAKREEILAAINAHPVVIIKGETGC 142
            ::..|::.|.    |.:::..:..|........|.: |.|:..|..||.....:..:||.|||||
 Worm    41 EERSTENAGAAPPIEEQLKVHNNPYASLNIQQQRIR-LPIFKNRGHILYMCERYRTIIIVGETGC 104

  Fly   143 GKTTQVPQYILDEAYKS-GKYCNIVVTQPRRIAAISIANRVCQEREWQQNTVCSFQVGL---HRP 203
            ||:|||||::|:..:.: |:  .||:|||||:|.:::|.||.:|::    .:....||.   ...
 Worm   105 GKSTQVPQFLLEAGWAADGR--QIVITQPRRVAVVTLATRVAEEKD----CILGHDVGYTVRFDD 163

  Fly   204 NSLEDTRLLYCTTGVLLNNLINNKTLTHYTHIVLDEVHERDQNMDFLLIVVRRLLATNSRHVKII 268
            .|.:||::.:.|.|:||..::.:..|:.|:.|::||.|||..|.|.||.::|:::...: .::||
 Worm   164 VSDKDTKVKFMTDGLLLREILADPLLSKYSIIMIDEAHERSCNTDILLGLLRKIIQIRN-DLRII 227

  Fly   269 LMSATIDAKELSDYF---TTTNS-------------IPPVITTNHRRKHSIEKFYRDQLGSIIWN 317
            :.|||:||:...|:|   .|.||             ..||..  |..|.|:..:.:..:.::|
 Worm   228 VSSATLDAELFKDFFEMNETGNSDKDTAGIISVEGRTHPVAV--HHTKTSVPDYCQSAVDTVI-- 288

  Fly   318 EEDVGHQQVPEINKHGYRAAVKIIVIIDNMERKAAIQSRQSYDEALRYGAVLIFLPGIYEIDTMA 382
                      .|:||            :|.                  |.:|:||.|..|::.:.
 Worm   289 ----------NIHKH------------ENP------------------GDILVFLTGQDEVEDVC 313

  Fly   383 ENLTCMLENDPNI-KVSIVRCFSLMTPENQRDVFNPPPPGFRKIILTTNIAESSITVPDVSYVID 446
            |.|..:..|..|. ::.:|.|:..:....|...|:..|.|.||:::.|||||:|||:|.:.||||
 Worm   314 EKLRELAGNLKNCDRLWVVPCYGALPAREQMKAFDSTPHGTRKVVVATNIAEASITIPGICYVID 378

  Fly   447 FCLAKVKVTDTASSFSSLRLTWASKANCRQRAGRVGRLRSGRVYRMVNKHFYQREMPEFGIPEML 511
            ....|::....|:...:|.....|||:..|||||.||:|.|:.||:..:..::| ..|..:||:.
 Worm   379 TGYVKLRAQHAANGVETLMRVTVSKASAEQRAGRAGRIRPGKCYRLYPESEFER-FAEGTVPEIQ 442

  Fly   512 RLPLQNSVLKAKVLNMGSPVEILALALSPPNLSDIHNTILLLKEVGALYLTVDGIYDPLDGDLTY 576
            |..:.:::|:.|.|.:.:....  ..||||....:.|.:.||..:||:..| ..:..||
 Worm   443 RCQMASTILQLKALGVQNVHRF--HYLSPPPSWAMINGLELLYALGAIDET-SQLTSPL------ 498

  Fly   577 WGTIMSRLPLDTRQSRLIILGYIFNMLEEAIIIAAGLSTPGLFAHEGGRSQLGDSFWMHYIFSDG 641
             |..|:..||....|:.::....|....|.:.|.|.:....:|.....:....|.....:...:|
 Worm   499 -GLQMAEFPLPPMHSKCLLKSAEFGCSTEMVTIVAMMQIQDVFITPYRQRHQADVIRKKFAVEEG 562

  Fly   642 SGSDLVAIWRVYLTYLNI----VENGHDQESAIRWAKRFHVSLRSL-------KEIHLLVQELRV 695
            .          ::|.||:    ||||..:    :|.....|:.|.|       .::..|::...:
 Worm   563 D----------HMTMLNVFTKFVENGRSK----KWCSDHFVNYRGLMRADNVRSQLVRLLKRFEI 613

  Fly   696 -RCTHLGLIPFPVNPNQMMDDREKAIMLKVIIAGAF-------YPNYFTRSKESCADTDRNIYQT 752
             :.:..|||....|..|            .::.|.|       |...:...|||   ...|:|:.
 Worm   614 EKVSSRGLINCSENIRQ------------CLVTGFFSQAAQYHYTGKYMTVKES---FPFNMYKG 663

  Fly   753 ISGHDPCRTVYFTNFKPAYMGELYTRRIKELFQEVR-IPPE 792
            .|       :.|....|.::  ::|..:::..::|. |.||
 Worm   664 SS-------IMFKKDYPKWV--IFTEVMQDSIRDVTVIEPE 695

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spn-E	NP_476741.1	HrpA	114..>697	CDD:441249	169/615 (27%)
		DEXHc_TDRD9	115..295	CDD:350746	69/199 (35%)
		TUDOR	892..1016	CDD:425754
ddx-35	NP_497420.1	HrpA	95..>703	CDD:441249	185/701 (26%)