DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spn-E and rha-1

DIOPT Version :9

Sequence 1:	NP_476741.1	Gene:	spn-E / 41919	FlyBaseID:	FBgn0003483	Length:	1434	Species:	Drosophila melanogaster
Sequence 2:	NP_495890.2	Gene:	rha-1 / 174417	WormBaseID:	WBGene00004355	Length:	1301	Species:	Caenorhabditis elegans

Alignment Length:	789	Identity:	233/789 - (29%)
Similarity:	376/789 - (47%)	Gaps:	116/789 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 ELKRVAAAPQGYISSDPRLMATKFKSSEVPNRELIGTDYVSKIVAKEKCLLN-----GTLLNEQP 73
            |:...:|.|:.     |..:.|..|.::.|..|:.....:|....    |.|     .:.::|:|
Worm   291 EINETSATPEA-----PTSLLTDVKLAQFPVSEICSASNISWAPP----LQNWNPWRASNIDEEP 346

  Fly    74 Q--------GKRIRTLDDLDTDDEGEETEIRRDDEYYKKFRFNLNRDKNLSIYAKREEILAAINA 130
            .        .:||...:|....:..::...:|.:               |.:...||.|:..:..
Worm   347 LAFMSMEQISQRIMEKEDFKRGEALDKITAQRGE---------------LPVAQYRENIVQTVAE 396

  Fly   131 HPVVIIKGETGCGKTTQVPQYILDEAYK--SGKYCNIVVTQPRRIAAISIANRVCQEREWQQNTV 193
            :.|.:|||||||||:|||.|::|:...:  :|...|.||:|||||:|||:|.||..||..:....
Worm   397 NRVTLIKGETGCGKSTQVAQFLLESFLENSNGASFNAVVSQPRRISAISLAERVANERGEEVGET 461

  Fly   194 CSFQVGLHRPNSLEDTRLLYCTTGVLLNNLINNKTLTHYTHIVLDEVHERDQNMDFLLIVVRRLL 258
            |.:.|............:::||.||||..:.|.  |...:|:::||:||||.:.||:|||:|.::
Worm   462 CGYNVRFDSATPRPYGSIMFCTVGVLLRMMENG--LRGISHVIIDEIHERDVDTDFVLIVLREMI 524

  Fly   259 ATNSRHVKIILMSATIDAKELSDYFTTTNSIPPV-ITTNHRRKHSIEKFYRDQLGSIIWN----- 317
            :| .|.::::|||||||....:::|::...:.|. :.|.|.|...::.||   |..|:.|
Worm   525 ST-YRDLRVVLMSATIDTDLFTNFFSSIPDVGPTPVITMHGRTFPVQSFY---LEDILHNLQHMP 585

  Fly   318 ----------------EEDVGHQQVPEINKHGYRAAVKIIVIID---NMERKAAIQSRQSYD--- 360
                            ::|.|.::|.:..::       :.::.|   |...|.|:......|
Worm   586 EEPDQKKRKKGGPPPPDDDEGDEEVDDKGRN-------MNILTDPSINESLKTAMSRISEKDIPF 643

  Fly   361 ---EALRY--------GAVLIFLPGIYEIDTMAENLTCMLENDPNIKVSIVRCFSLMTPENQRDV 414
               ||:..        ||||:||||..||.|:...|....|.....|..|:...|.:|.:.||.|
Worm   644 GVIEAILNDIASRGVDGAVLVFLPGWAEIMTLCNRLLEHQEFGQANKYEILPLHSQLTSQEQRKV 708

  Fly   415 FNPPPPGFRKIILTTNIAESSITVPDVSYVIDFCLAKVKVTDTASSFSSLRLTWASKANCRQRAG 479
            || ..||.||||::|||||:|||:.||.||||.|.||.::..:.::.......||||.|..||.|
Worm   709 FN-HYPGKRKIIVSTNIAETSITIDDVVYVIDSCKAKERMYTSNNNMVHFATVWASKTNVIQRRG 772

  Fly   480 RVGRLRSGRVYRMVNKHFYQREMPEFGIPEMLRLPLQNSVLKAKVLNMGSPVEILALALSPPNLS 544
            |.||:|:|..:.:.:|..:: .:.:.|..||||:||....|..|:|.:||..|.|..||.||...
Worm   773 RAGRVRAGYAFHLCSKMRFE-ALDDHGTAEMLRIPLHQIALTIKLLRLGSVGEFLGKALQPPPYD 836

  Fly   545 DIHNTILLLKEVGALYLTVDGIYDPLDGDLTYWGTIMSRLPLDTRQSRLIILGYIFNMLEEAIII 609
            .:..:..:|:.:|||...:         :||..|.:::|:|::...::::|||...........:
Worm   837 MVVESEAVLQAMGALDRNL---------ELTSLGKMLARMPIEPVIAKVLILGTALGAGSVMCDV 892

  Fly   610 AAGLSTPGLFA-HEGGRSQLGDSFWMHYIFSDGSGSDLVAIWRVYLTYLNIVENGHDQESAIR-W 672
            |:.:|.|..|. .|...|:|..:   ...|:....||.|||..|...|...|:.|  ..:|.| :
Worm   893 ASAMSFPTPFVPREKHHSRLSGT---QRKFAGNKFSDHVAIVSVIQGYREAVQMG--ASAAEREF 952

  Fly   673 AKRFHVSLRSLKEI----HLLVQELRVRCTHLGLIPFPVNPNQMMDDREKAIMLKVIIAGAFYPN 733
            .:|:.:|...||..    ..|:..||.:|:....|.|.::.|....|||..:|..:::. |.|||
Worm   953 CERYSLSNPVLKMTDGARRQLIDVLRNQCSFPEDILFDISVNVNGPDRELNLMRSLLVM-ALYPN 1016

  Fly   734 --YFTRSKE 740
              |:...::
Worm  1017 VAYYVGKRK 1025

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spn-E	NP_476741.1	HrpA	113..>697	CDD:224557	203/630 (32%)
spn-E	NP_476741.1	TUDOR	892..1016	CDD:395449
rha-1	NP_495890.2	DSRM	6..71	CDD:214634
		DSRM	173..243	CDD:214634
		HrpA	337..>974	CDD:224557	206/680 (30%)
		DEXDc	398..539	CDD:238005	61/143 (43%)
		Helicase_C	649..739	CDD:278689	40/90 (44%)
		HA2	847..931	CDD:214852	23/95 (24%)
		OB_NTP_bind	971..1086	CDD:285018	16/56 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D278674at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820