DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spn-E and mog-5

DIOPT Version :9

Sequence 1:	NP_476741.1	Gene:	spn-E / 41919	FlyBaseID:	FBgn0003483	Length:	1434	Species:	Drosophila melanogaster
Sequence 2:	NP_495019.1	Gene:	mog-5 / 173920	WormBaseID:	WBGene00003393	Length:	1200	Species:	Caenorhabditis elegans

Alignment Length:	845	Identity:	222/845 - (26%)
Similarity:	369/845 - (43%)	Gaps:	165/845 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 EKCLLNGTLLNEQP----QGKRIRTLDDLDTD-----------------------DEGEE--TEI 95
            :..|:.|.|..|:.    |.:|.|   |:||.                       ||.::  .::
Worm   446 QAALMQGALSKERKETKIQAQRER---DMDTQKGFSSNARILDPMSGNQSTAWSADESKDRNNKM 507

  Fly    96 RRDDEYYKKF----------RFNLN---RDKNLSIYAKREEILAAINAHPVVIIKGETGCGKTTQ 147
            :...|:.|..          |.||:   :.::|.|:|.::.::.|:..:.::::.||||.|||||
Worm   508 KEMPEWLKHVTAGGKATYGRRTNLSMVEQRESLPIFALKKNLMEAMIDNQILVVVGETGSGKTTQ 572

  Fly   148 VPQYILDEAYKSGKYCNIVVTQPRRIAAISIANRVCQEREWQQNTVCSFQVGLHRPNSLEDTRLL 212
            :.||.::...  |:...|..|||||:||:|:|.||.:|...:..|...:.:......| :||.:.
Worm   573 MTQYAIEAGL--GRRGKIGCTQPRRVAAMSVAKRVAEEYGCKLGTDVGYTIRFEDCTS-QDTIIK 634

  Fly   213 YCTTGVLLNNLINNKTLTHYTHIVLDEVHERDQNMDFLLIVVRRLLATNSRHVKIILMSATIDAK 277
            |.|.|:||...:.:..|:.|:.|:|||.|||..:.| :|..:.:..|.....:|:|:.|||:|:.
Worm   635 YMTDGMLLRECLIDPDLSGYSLIMLDEAHERTIHTD-VLFGLLKAAARKRPELKLIITSATLDSV 698

  Fly   278 ELSDYFTTTNSIPPVITTNHRRKHSIEKFYRDQLGSIIWNEEDVGHQQVPEINKHGYRAAVKIIV 342
            :.|:||...    |:.|. ..|...:|         |::..|       ||.:   |..|..|.|
Worm   699 KFSEYFLEA----PIFTI-PGRTFPVE---------ILYTRE-------PESD---YLEAAHITV 739

  Fly   343 IIDNMERKAAIQSRQSYDEALRYGAVLIFLPGIYEIDTMAENL-TCMLENDPNI-KVSIVRCFSL 405
            :..::....              |.||:||.|..||||..|.| ..|....|:: ::.|:..:..
Worm   740 MQIHLTEPP--------------GDVLVFLTGQEEIDTSCEVLYERMKSMGPDVPELIILPVYGA 790

  Fly   406 MTPENQRDVFNPPPPGFRKIILTTNIAESSITVPDVSYVIDFCLAKVKVTDTASSFSSLRLTWAS 470
            :..|.|..:|:|.|.|.||:::.|||||:|:|:..:.||:|....|.|:.:..|...||.:|..|
Worm   791 LPSEMQTRIFDPAPAGKRKVVIATNIAETSLTIDGIFYVVDPGFVKQKIYNPKSGMDSLVVTPIS 855

  Fly   471 KANCRQRAGRVGRLRSGRVYRMVNKHFYQREMPEFGIPEMLRLPLQNSVLKAKVLNMGSPVEILA 535
            :|..:||:||.||...|:.||:..:..::.||....:||:.|..|.:::|:.|.:.:.:.::.
Worm   856 QAAAKQRSGRAGRTGPGKCYRLYTERAFRDEMLPTPVPEIQRTNLASTLLQLKAMGINNLIDF-- 918

  Fly   536 LALSPPNLSDIHNTILLLKEVGALYLTVDGIYDPLDGDLTYWGTIMSRLPLDTRQSRLIILGYIF 600
            ..:..|.|..:...:..|..:.||    ||     ||.||..|..|:..||:...|:|:|:....
Worm   919 DFMDAPPLDSMITALNTLHTLSAL----DG-----DGLLTKLGRRMAEFPLEPSLSKLLIMSVDL 974

  Fly   601 NMLEEAIIIAAGLSTPGLFAHEGGRSQLGDSFWMHYIFSDGSGSDLVAIWRVYLTYLNIVENGHD 665
            ...||.:.|.|.|:...:|.....:....|.....:...:|....|:|::       |..:|.|.
Worm   975 GCSEEVLTIVAMLNVQNIFYRPKEKQDHADQKKAKFHQPEGDHLTLLAVY-------NSWKNHHF 1032

  Fly   666 QESAIRWAKRFHVSLRSLKEIHLLVQELRVRCTHLGLIPFPVNPNQMMDDREKAIML-------- 722
            .:.   |.....:.:||:|.    .|::|.:.  ||::           ||.|.:|:
Worm  1033 SQP---WCFENFIQVRSMKR----AQDIRKQL--LGIM-----------DRHKLLMVSCGRDVSR 1077

  Fly   723 --KVIIAGAFYPNYFTRSKESCADT---DRNIYQTISG----HDPCRTVYFTNFKPAYMGELYTR 778
              |.|.:| |:.|...|..:....|   .:|:|...|.    ..|...||.         || ..
Worm  1078 VQKAICSG-FFRNAAKRDPQEGYRTLTDGQNVYIHPSSACFQQQPEWVVYH---------EL-VM 1131

  Fly   779 RIKELFQEV-RIPP----ENMDVTFQEGSQKVFVTFKQDDWIEG-SSKYVPVSG----RVQSEVY 833
            ..||..:|| .|.|    |.....|:.|......|||::..|:. ..||...:.    ||:..:|
Worm  1132 TTKEYMREVTAIDPKWLVEFAPSFFKIGDSTKLSTFKRNQKIDPLFDKYADANAWRITRVKKRIY 1196

Fly 834 833
Worm 1197 1196

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spn-E	NP_476741.1	HrpA	113..>697	CDD:224557	166/585 (28%)
spn-E	NP_476741.1	TUDOR	892..1016	CDD:395449
mog-5	NP_495019.1	S1_DHX8_helicase	234..311	CDD:240189
		DEXDc	534..721	CDD:214692	63/204 (31%)
		DEXDc	557..695	CDD:238005	50/141 (35%)
		HELICc	766..870	CDD:197757	37/103 (36%)
		HA2	939..1021	CDD:214852	23/90 (26%)
		OB_NTP_bind	1055..1154	CDD:285018	28/122 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810