Protein Alignment spn-E and ythc-2

DIOPT Version :10

• Sequence 1: NP_476741.1
• Gene: spn-E / 41919
• FlyBaseID: FBgn0003483
• Length: 1434
• Species: Drosophila melanogaster
• Sequence 2: NP_492260.1
• Gene: ythc-2 / 172615
• WormBaseID: WBGene00009922
• Length: 1425
• Species: Caenorhabditis elegans
• Alignment Length: 1112
• Identity: 277/1112 - (24%)
• Similarity: 423/1112 - (38%)
• Gaps: 376/1112 - (33%)

  Fly    10 DFSKELKRVA----------------AAPQGYISSDPRL----------MATKFKSSEVPNRELI 48
            |..||.:|||                ..|.|   .|.|.          |.||....| |:|.:|
 Worm    36 DTRKEYRRVANEIIRSFLKSGQKNTTLEPMG---RDQRKVMHEVALLNEMTTKSHGRE-PDRYMI 96

  Fly    49 GTDYVSKIVAKEKCLLNGTLLNEQPQGKRIRTLDDLD--------TDDEGEE--TEIRRDDEYYK 103
                :||.|.:   |...||:..:|.......|..|.        |.:|.:|  ||.:....:..
 Worm    97 ----LSKRVNR---LSKSTLVATEPITPSFECLQKLSKFVEKHPITREEMDEFLTETQTKQMHTT 154

  Fly   104 KFRFN--------------LNRDKNLSIYAKR--EEILAAINAHPVVIIKGETGCGKTTQVPQYI 152
            |...:              |.:.:| |:.|.:  :::|.:|::..||||.|.|||||||||||:|
 Worm   155 KGHISDRMVIPPKSKCSKELQKVRN-SLPASKYCDQVLKSISSCNVVIISGGTGCGKTTQVPQFI 218

  Fly   153 LDEAYKSGKYCNIVVTQPRRIAAISIANRVCQEREWQQNTVCSFQVGLHRPNSLEDTRLLYCTTG 217
            ||||:::.|:..::|||||||||||||.||.:||.........:||.|....| :||.|.|||||
 Worm   219 LDEAHENNKHVRVMVTQPRRIAAISIAERVARERGEPIGRTVGYQVRLDSRRS-DDTVLTYCTTG 282

  Fly   218 VLLNNLINNKTLTHYTHIVLDEVHERDQNMDFLLIVVRRLLATNSRHVKIILMSATIDA--KELS 280
            |||..|.::...:..||||:||:|||:.|.|:|||.:|..|.... .:|:|||||||:.  :..|
 Worm   283 VLLRMLTSDPVASGITHIVMDEIHEREINTDYLLIALRECLKMRP-DLKVILMSATIEGNMQLFS 346

  Fly   281 DYFTTTNSIPPVITTNHRRKHSIEKFYRDQLGSII--------------------WNEE------ 319
            :||  .|....||.. ..|...::.||.||:.::.                    |.:|
 Worm   347 NYF--ENHSMDVIRI-ESRAFDVKVFYLDQILAMTGYQPPESKAFFSTAEYEEEDWKDEIEAVER 408

  Fly   320 ---DVGHQQVPE----------------------------------------INKHGYRAAVKII 341
               |...|:..:                                        |::...|..:.||
 Worm   409 EEKDKAKQRAADSSLSTLSKPVTKMAANTKRNSPIEEREWTSGPCSTPDGDIIDERAMRQYMNII 473

  Fly   342 --------------------VIIDNM--------------------------------------- 347
                                |.|:::
 Worm   474 GNPDIRPVITVEFRPTTPNSVFINDVKYTTNPNQSAQALLQQKRERCLMPRGPLTFTCENPASTT 538

  Fly   348 -----------------------------------------ERKAAIQSRQSY------------ 359
                                                     |.|.|:..|..|
 Worm   539 KSPPSPTPTLGISSGLAKFTPFGGFGEKQRISTLLEKKFKEELKTALPDRTVYYHPQMNDVVDKT 603

  Fly   360 ----------------------------DEALRY-------GAVLIFLPGIYEIDTMAENLTCML 389
                                        |:.::|       |.:|:||||..:|..|.:.:.|..
 Worm   604 DFSKLRFGEKYNLFYGSSSNNSVDYVLLDQVIQYLADSPVFGTILVFLPGYEDIQQMLKAIDCWK 668

  Fly   390 ENDPNIK-VSIVRCFSLMTPENQRDVFNPPPPGFRKIILTTNIAESSITVPDVSYVIDFCLAKVK 453
            .:..|:| |.::...|.||..|..|:|...|...|||||.|||||:|||:.||.:|:|....|.|
 Worm   669 NSLKNMKNVIVLPLHSQMTSINHGDIFKSVPKDTRKIILATNIAEASITIEDVIFVVDTGKVKEK 733

  Fly   454 VTDTASSFSSLRLTWASKANCRQRAGRVGRLRSGRVYRMVNKHFYQREMPEFGIPEMLRLPLQNS 518
            ..|..:..|:|.:...:::|..||:||.||:.:|...|:..:..| ..|||..|.||.|..:.:.
 Worm   734 SFDHEAKLSTLTVKPIARSNADQRSGRAGRVANGYCIRLYTEQEY-NSMPETQIAEMKRAAIYDV 797

  Fly   519 VLKAKVLNMGSP-----VEILALALSPPNLSDIHNTILLLKEVGALYLTVDGIYD---------- 568
            .|.||:.   :|     .|.|:||..||....|...|..|:::||.|..:. |||
 Worm   798 TLHAKLF---APKTLKISEFLSLAPEPPEKESILQAITFLEQIGAFYTPIK-IYDNSGNEEGLKN 858

  Fly   569 ---------PLDGDLTYWGTIMSRLPLDTRQSRLIILGYIFNMLEEAIIIAAGLST--PGLFAHE 622
                     |.|.:||..|.:|:|||||.:.||:::.|.....|...:.:.|.|::  |.:.|..
 Worm   859 DEEAENSENPEDPELTDLGRLMARLPLDPQLSRMLLFGLALKCLTPIVNLVALLASREPYVLALS 923

  Fly   623 GGRSQLGDSFWMHYIFSDGSGSDLVAIWRVYLTYLNIV-----ENGHDQESAIRWAKRFHVSLRS 682
            ..|.....   |.:..:....||       :|.|:.:.     :|...|.   ::.:...::..:
 Worm   924 EDRDLQSK---MKFEMAQQDLSD-------HLLYIRLCNEFCSKNNSQQN---QFCRDHFLNFST 975

  Fly   683 LKEI----HLLVQELRVRCTHLGLIPFPVNPNQ-----MMDDREKAI-----MLKVIIAGAFYPN 733
            ::.:    ..|::|| ||...:.     ::||:     :.|......     |::.:||...||.
 Worm   976 MRMVQGTRRQLLREL-VRAKLIN-----ISPNRDVLTVLTDHHFNQFSQCWPMIQAVIAAGCYPF 1034

  Fly   734 YFTRSKESCADTDRNIYQTISGHDPCRTVYFTNFKPAYM--GELYTRRIKELFQEVRIPPENMDV 796
            ....:.||      |:          :.|...|.|||::  ..:..::|.::.:..:.|.... |
 Worm  1035 IGVSASES------NL----------KKVQTFNDKPAFLHPSSMVKKQIVKMGKSEKSPRVEY-V 1082

  Fly   797 TFQEGSQ 803
            .|||..|
 Worm  1083 AFQEMCQ 1089

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spn-E	NP_476741.1	HrpA	114..>697	CDD:441249	220/838 (26%)
		DEXHc_TDRD9	115..295	CDD:350746	89/183 (49%)
		TUDOR	892..1016	CDD:425754
ythc-2	NP_492260.1	R3H	21..100	CDD:214647	18/71 (25%)
		DEXHc_RHA-like	198..359	CDD:438707	85/164 (52%)
		HrpA	<630..>988	CDD:441249	107/375 (29%)
		OB_NTP_bind	1023..1116	CDD:400182	19/84 (23%)