DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spn-E and let-355

DIOPT Version :9

Sequence 1:	NP_476741.1	Gene:	spn-E / 41919	FlyBaseID:	FBgn0003483	Length:	1434	Species:	Drosophila melanogaster
Sequence 2:	NP_491604.3	Gene:	let-355 / 172199	WormBaseID:	WBGene00020263	Length:	856	Species:	Caenorhabditis elegans

Alignment Length:	900	Identity:	218/900 - (24%)
Similarity:	366/900 - (40%)	Gaps:	194/900 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 FDFSKELKRVAAAPQGYISS---------------------------DPRLMATKFKSSEVPN-- 44
            |...|:.|::...|...||.                           ..:.|..|.|..::.|
Worm    17 FQIDKDGKKIKPNPGAQISKILQNGKVNGNSRQTGGQEQKFQNLEALKKKTMLLKKKKKQMNNFQ 81

  Fly    45 --RELIGTDY--VSKIVAKEKCLLNGTLLNEQPQGKRIRTLDDLDTDDEGEE----TEIRRDDEY 101
              .||:.:.:  .:.|:.|||.:...|:..:.|: |..:|  .:.|....:.    :..:.....
Worm    82 KEEELLSSTFRITNGILKKEKKIEVTTISTQTPK-KLPKT--PISTPSNSKNATPMSTRKHSSSQ 143

  Fly   102 YKKFRFNLNRDK----NLSIYAKREEILAAINAHPVVIIKGETGCGKTTQVPQYILDEAY-KSGK 161
            .....|..|.:|    .|.|.|..::::..:.:...:|:.||||.||:|||||..:.... .||
Worm   144 QSPPHFEANYEKFSRPQLPIDAVEQQLMYELASQETLIVIGETGSGKSTQVPQLCVRAGIANSG- 207

  Fly   162 YCNIVVTQPRRIAAISIANRVCQEREWQQNTVCSFQVGLHRPNSLEDTRLLYCTTGVLLNNLINN 226
              :|.||||||:||||:|:||..|.......:..:.|..... :...|::.|.|.|::|...:.:
Worm   208 --SIAVTQPRRVAAISLASRVATEMGTNIGGIVGYHVRFENA-TCHKTKIEYMTDGIVLRKALVS 269

  Fly   227 KTLTHYTHIVLDEVHERDQNMDFLLIVVRRL----LATNSRHVKIILMSATIDAKELSDYFTTTN 287
            ..|..|:.:::||.|||..:.|.|:.::|:.    ..||: .:::|:||||:.|::...||   |
Worm   270 PLLDKYSCVIIDEAHERSLHSDVLMCILRQCQDQRRETNN-PLRLIIMSATLQAEKFQSYF---N 330

  Fly   288 SIPPVITTNHRRKHSIEKFYRDQLGSIIWNEEDVGHQQVPEINK------HGYRA--AVKIIVII 344
            :...|:...  |...||.|:.:                 |:|||      :.|.|  .||.:.:.
Worm   331 NAKVVLVAG--RTFPIEVFHVN-----------------PKINKSFSSTDYVYNAVICVKYVHLT 376

  Fly   345 DNMERKAAIQSRQSYDEALRYGAVLIFLPGIYEIDTMAENLTCMLENDPNIKVSI-----VRCFS 404
            :...|.                 :|:||.|..||:.:|..|.   |.:.::..|.     |..::
Worm   377 EPKGRD-----------------ILVFLTGSEEIEAVASQLA---ELNGSLPASADVLMPVPLYA 421

  Fly   405 LMTPENQRDVFNPPPPGFRKIILTTNIAESSITVPDVSYVIDFCLAKVKVTDTASSFSSLRLTWA 469
            .:.||.|::.|...|.|.||:|::|||||:|:|:|.:..|||....|.|..:..:....|::...
Worm   422 ALRPEKQKEAFRKTPQGARKVIISTNIAETSVTIPGIRVVIDSGKVKTKRFEAFNRIDVLKVHNV 486

  Fly   470 SKANCRQRAGRVGRLRSGRVYRMVNK---HFYQREMPEFGIPEMLRLPLQNSVLKAKVLNMGSPV 531
            |||..:|||||.||...|:.||:.::   |.::.|    .:||:||..|..:.|:...|.|.:|.
Worm   487 SKAQAKQRAGRAGRDAPGKCYRLYSREDFHKFEAE----NMPEILRCNLSATFLELMKLGMKNPH 547

  Fly   532 EILALALSPPNLSDIHNTILLLKEVGALYLTVDGIYDPLDGD-----LTYWGTIMSRLPLDTRQS 591
            .:  ..:.||...:|:..:|.|..:||:        .|::.|     ||..|......||....:
Worm   548 RL--KLIDPPETDNINAALLELTSLGAI--------RPVNSDRSKFALTEMGDAFCMYPLPPDHA 602

  Fly   592 RLIILGYIFNMLEEAIIIAAGLSTPGLFAHEGGRSQLGDSFWMHYIFSDGSGSDLVAIWRVYLTY 656
            |::........:.|||.|.|.:.|..||:..|......|...:...|....|..:..:..|.:|.
Worm   603 RILFQAQKEGCIMEAIKIVAAMQTDALFSGAGDSKSDADVDRIRRRFETREGDHITLLKLVLVTN 667

  Fly   657 LNIVENGHDQESAIRWAKRFHVSLRSLKEIHLLVQELRVRCTHLGLIPFPVNPNQMMDDREKAI- 720
            ....:.....||..|:.|    :.:||:..:  .|.:|..|....:....:....|::::.|.|
Worm   668 QFFDQLNKKTESDARYGK----ANKSLEREY--NQTIRKFCNDNMINEQHLKTASMIEEQLKQIA 726

  Fly   721 ----------------MLKVIIAGAFYPNYFTRSKESCA-DTDRNIYQ-------TISGH-DPCR 760
                            |.|.:..|.|.        .||. |...:.|:       |:..| ..|
Worm   727 IEQKVTFSTCGADFMKMRKALALGMFL--------NSCEYDRQEDRYRLMINPAITLKIHPSSC- 782

  Fly   761 TVYFTNFKPAYMGELYTRRIKELFQEVRIPPENMDVTFQEGSQKVFVTFKQDDWI 815
               .:..||||:......:..:||.        :.||..:|           ||:
Worm   783 ---LSRSKPAYIVFSELMKTNDLFA--------LQVTLIDG-----------DWV 815

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spn-E	NP_476741.1	HrpA	113..>697	CDD:224557	169/613 (28%)
spn-E	NP_476741.1	TUDOR	892..1016	CDD:395449
let-355	NP_491604.3	HrpA	149..>800	CDD:224557	190/729 (26%)
		DEXDc	180..320	CDD:238005	51/144 (35%)
		Helicase_C	383..500	CDD:278689	42/119 (35%)
		HA2	569..660	CDD:214852	22/98 (22%)
		OB_NTP_bind	712..822	CDD:285018	25/134 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810