DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment spn-E and DHX36

DIOPT Version :9

Sequence 1:NP_476741.1 Gene:spn-E / 41919 FlyBaseID:FBgn0003483 Length:1434 Species:Drosophila melanogaster
Sequence 2:NP_065916.2 Gene:DHX36 / 170506 HGNCID:14410 Length:1008 Species:Homo sapiens


Alignment Length:925 Identity:262/925 - (28%)
Similarity:418/925 - (45%) Gaps:177/925 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    21 APQ--GYISSDPRLMATKFKSSEVPNRELIGTDYVSKIVAKEKCLLNGTLLNEQPQGKRIRTLDD 83
            ||:  ||        .|:..:...|..|       :|:..:||     .|:|::.:..|||....
Human   118 APEDHGY--------GTEVSTKNTPCSE-------NKLDIQEK-----KLINQEKKMFRIRNRSY 162

  Fly    84 LDTDDEGEETEIRRDDEYYKKFRFNLNRDKN-------------LSIYAKREEILAAINAHPVVI 135
            :|.|.|....|...|....:|...:|.:.||             |..|..::|::..|:.|.|.:
Human   163 IDRDSEYLLQENEPDGTLDQKLLEDLQKKKNDLRYIEMQHFREKLPSYGMQKELVNLIDNHQVTV 227

  Fly   136 IKGETGCGKTTQVPQYILDEAYKSGK--YCNIVVTQPRRIAAISIANRVCQER--EWQQNTVCSF 196
            |.|||||||||||.|:|||...:.||  .|.||.||||||:|||:|.||..||  .........:
Human   228 ISGETGCGKTTQVTQFILDNYIERGKGSACRIVCTQPRRISAISVAERVAAERAESCGSGNSTGY 292

  Fly   197 QVGLHRPNSLEDTRLLYCTTGVLLNNLINNKTLTHYTHIVLDEVHERDQNMDFLLIVVRRLLATN 261
            |:.|......:...:||||||::|..|.::..|:..:||||||:|||:...|.|:.||:.||...
Human   293 QIRLQSRLPRKQGSILYCTTGIILQWLQSDPYLSSVSHIVLDEIHERNLQSDVLMTVVKDLLNFR 357

  Fly   262 SRHVKIILMSATIDAKELSDYFTTTNSIP------PVIT-------------------------- 294
            | .:|:||||||::|::.|:||.....|.      ||:.                          
Human   358 S-DLKVILMSATLNAEKFSEYFGNCPMIHIPGFTFPVVEYLLEDVIEKIRYVPEQKEHRSQFKRG 421

  Fly   295 -----TNHRRKHSIEKFYRDQLGSIIWNEEDVGHQQVPEINKHGYRAAVKIIVII--DNMERKAA 352
                 .|.:.|...|..|:::     |.:      .|.|:.:....:.|.:|.::  |.::....
Human   422 FMQGHVNRQEKEEKEAIYKER-----WPD------YVRELRRRYSASTVDVIEMMEDDKVDLNLI 475

  Fly   353 IQSRQSYDEALRY-------GAVLIFLPGIYEIDTMAENL--TCMLENDPNIKVSIVRCFSLMTP 408
            :       ..:||       ||:|:||||...|.|:.:.|  ..|.::|   |..|:...|||..
Human   476 V-------ALIRYIVLEEEDGAILVFLPGWDNISTLHDLLMSQVMFKSD---KFLIIPLHSLMPT 530

  Fly   409 ENQRDVFNPPPPGFRKIILTTNIAESSITVPDVSYVIDFCLAKVKVT--DTASSFSSLRLTWASK 471
            .||..||...|||.|||::.|||||:|||:.||.||||.  .|:|.|  ||.::.|::...|.||
Human   531 VNQTQVFKRTPPGVRKIVIATNIAETSITIDDVVYVIDG--GKIKETHFDTQNNISTMSAEWVSK 593

  Fly   472 ANCRQRAGRVGRLRSGRVYRMVNKHFYQREMPEFGIPEMLRLPLQNSVLKAKVLNMGSPVEILAL 536
            ||.:||.||.||::.|..|.:.| ......:.::.:||:||.||:...|:.|:|.:|.....|:.
Human   594 ANAKQRKGRAGRVQPGHCYHLYN-GLRASLLDDYQLPEILRTPLEELCLQIKILRLGGIAYFLSR 657

  Fly   537 ALSPPNLSDIHNTILLLKEVGALYLTVDGIYDPLDGDLTYWGTIMSRLPLDTRQSRLIILGYIFN 601
            .:.||:...:..:|..|.|:.||        |..: :||..|..::|||::....::|:.|.:|.
Human   658 LMDPPSNEAVLLSIRHLMELNAL--------DKQE-ELTPLGVHLARLPVEPHIGKMILFGALFC 713

  Fly   602 MLEEAIIIAAGLSTPGLFAHEGGRSQLGDSFWMHYIFSDGSGSDLVAIWRVYLTYLNIVENGHD- 665
            .|:..:.|||.||....|....|:.::.|:  .....:..:.||       :||.:|..|...: 
Human   714 CLDPVLTIAASLSFKDPFVIPLGKEKIADA--RRKELAKDTRSD-------HLTVVNAFEGWEEA 769

  Fly   666 QESAIRWAK----RFHVSLRSLKEIHLLVQELRVRCTHLGLIPF--PVNP-NQMMDDREKAIMLK 723
            :....|:.|    .:.:|..:|:.:|.:..:........|.:..  |.:| :.:..|.||  ::|
Human   770 RRRGFRYEKDYCWEYFLSSNTLQMLHNMKGQFAEHLLGAGFVSSRNPKDPESNINSDNEK--IIK 832

  Fly   724 VIIAGAFYP-------NYFTRSKESCADTDRNIYQTISG----HDPCRTVYFTNFKPAYMGELYT 777
            .:|....||       |...:.|..      .:|....|    |.....|..|:|.  |...:|.
Human   833 AVICAGLYPKVAKIRLNLGKKRKMV------KVYTKTDGLVAVHPKSVNVEQTDFH--YNWLIYH 889

  Fly   778 RRIKE----LFQEVRIPPENM-----DVTFQEGSQKVFVTFKQDDWIEGSSKYVPVS-GRVQSEV 832
            .:::.    |:....:.|..:     |::.|:.:.:  .|...|:||...|   |.. ..:..|:
Human   890 LKMRTSSIYLYDCTEVSPYCLLFFGGDISIQKDNDQ--ETIAVDEWIVFQS---PARIAHLVKEL 949

  Fly   833 YKAV-MMRQNRVERP 846
            .|.: ::.|.::|.|
Human   950 RKELDILLQEKIESP 964

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
spn-ENP_476741.1 HrpA 113..>697 CDD:224557 205/655 (31%)
TUDOR 892..1016 CDD:395449
DHX36NP_065916.2 Necessary for nuclear and nucleolar caps localizations. /evidence=ECO:0000269|PubMed:18279852 1..200 24/101 (24%)
Required for the pre-miR-134 transport. /evidence=ECO:0000250|UniProtKB:D4A2Z8 1..104
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..58
Required for recruitment to cytoplasmic stress granules. /evidence=ECO:0000269|PubMed:18854321 1..51
Required for G4-DNA-and G4-RNA-binding. /evidence=ECO:0000269|PubMed:21149580, ECO:0000269|PubMed:21846770, ECO:0000269|PubMed:24151078 53..105
DSM (DHX36-specific motif). /evidence=ECO:0000269|PubMed:20472641, ECO:0000269|PubMed:22238380, ECO:0000269|PubMed:24369427, ECO:0000269|PubMed:26195789, ECO:0000269|PubMed:26649896 53..75
RecA-like domain 1. /evidence=ECO:0000250|UniProtKB:Q05B79 106..386 104/288 (36%)
DEXDc 210..392 CDD:214692 79/182 (43%)
DEXDc 224..369 CDD:238005 69/145 (48%)
Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79 265..317 19/51 (37%)
DEAH box. /evidence=ECO:0000255|PROSITE-ProRule:PRU00541 334..337 2/2 (100%)
RecA-like domain 2. /evidence=ECO:0000250|UniProtKB:Q05B79 387..628 75/264 (28%)
Helicase_C 476..606 CDD:278689 59/141 (42%)
Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79 498..557 25/61 (41%)
Nuclear localization signal. /evidence=ECO:0000303|PubMed:14731398 517..528 4/13 (31%)
WH domain. /evidence=ECO:0000250|UniProtKB:Q05B79 629..698 24/77 (31%)
Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79 638..697 17/67 (25%)
HA2 676..760 CDD:214852 26/101 (26%)
OB_NTP_bind 800..917 CDD:285018 22/126 (17%)
OB-fold-like subdomains. /evidence=ECO:0000250|UniProtKB:Q05B79 841..905 12/71 (17%)
Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79 849..860 2/16 (13%)
Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79 870..900 6/31 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1643
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D278674at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

Return to query results.
Submit another query.