DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spn-E and DHX15

DIOPT Version :9

Sequence 1:	NP_476741.1	Gene:	spn-E / 41919	FlyBaseID:	FBgn0003483	Length:	1434	Species:	Drosophila melanogaster
Sequence 2:	NP_001349.2	Gene:	DHX15 / 1665	HGNCID:	2738	Length:	795	Species:	Homo sapiens

Alignment Length:	773	Identity:	210/773 - (27%)
Similarity:	339/773 - (43%)	Gaps:	131/773 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 TEIRRDDEYYKKFRFNLNRDKNLSIYAKREEILAAINAHPVVIIKGETGCGKTTQVPQYILDEAY 157
            |.:.....||...:..|    .|.::..::.....:..|...::.||||.|||||:||:.: |..
Human   119 TNLPHTPRYYDILKKRL----QLPVWEYKDRFTDILVRHQSFVLVGETGSGKTTQIPQWCV-EYM 178

  Fly   158 KS--GKYCNIVVTQPRRIAAISIANRVCQEREWQQNTVCSFQVGLHRPNSLEDTRLLYCTTGVLL 220
            :|  |....:..|||||:||:|:|.||..|.:........:.:.....:|.: |.|.|.|.|:||
Human   179 RSLPGPKRGVACTQPRRVAAMSVAQRVADEMDVMLGQEVGYSIRFEDCSSAK-TILKYMTDGMLL 242

  Fly   221 NNLINNKTLTHYTHIVLDEVHERDQNMDFLLIVVRRLLATNSRHVKIILMSATIDAKELSDYFTT 285
            ...:|:..|..|..|:|||.|||....|.|:.|::.::...| .:|:|:||||:||.:...||..
Human   243 REAMNDPLLERYGVIILDEAHERTLATDILMGVLKEVVRQRS-DLKVIVMSATLDAGKFQIYFDN 306

  Fly   286 TNSIPPVITTNHRRKHSIEKFYRDQLGSIIWNEEDVGHQQVPEINKHGYRAAVKIIVIIDNMERK 350
            .    |::|. ..|.|.:|.||                  .||..:....||::.::.|...|.:
Human   307 C----PLLTI-PGRTHPVEIFY------------------TPEPERDYLEAAIRTVIQIHMCEEE 348

  Fly   351 AAIQSRQSYDEALRYGAVLIFLPGIYEIDTMAENLTCMLEN-DPNI-KVSIVRCFSLMTPENQRD 413
            .              |.:|:||.|..|||...:.:...::: .|.: .:.|:..:|.:.|:.|:.
Human   349 E--------------GDLLLFLTGQEEIDEACKRIKREVDDLGPEVGDIKIIPLYSTLPPQQQQR 399

  Fly   414 VFNPPPP-------GFRKIILTTNIAESSITVPDVSYVIDFCLAKVKVTDTASSFSSLRLTWASK 471
            :|.||||       | ||::::|||||:|:|:..|.:|||...||.||.:......||.:|..||
Human   400 IFEPPPPKKQNGAIG-RKVVVSTNIAETSLTIDGVVFVIDPGFAKQKVYNPRIRVESLLVTAISK 463

  Fly   472 ANCRQRAGRVGRLRSGRVYRMVNKHFYQREMPEFGIPEMLRLPLQNSVLKAKVLNMGSPVEILAL 536
            |:.:|||||.||.|.|:.:|:..:..|:.||.:...||:||..|.:.||:.|.|.:...|..  .
Human   464 ASAQQRAGRAGRTRPGKCFRLYTEKAYKTEMQDNTYPEILRSNLGSVVLQLKKLGIDDLVHF--D 526

  Fly   537 ALSPPNLSDIHNTILLLKEVGALYLTVDGIYDPLDGDLTYWGTIMSRLPLDTRQSRLIILGYIFN 601
            .:.||....:...:.||..:.||       .|  |||||..|::|:..|||.:.::::|....:|
Human   527 FMDPPAPETLMRALELLNYLAAL-------ND--DGDLTELGSMMAEFPLDPQLAKMVIASCDYN 582

  Fly   602 MLEEAIIIAAGLSTPGLFAHEGGRSQLGDSFWMHYIFSDGSGSDLVAIWRVYLTYLNIVENGHDQ 666
            ...|.:.|.|.||.|..|.......:..|...|.:...||.          :||.||:.......
Human   583 CSNEVLSITAMLSVPQCFVRPTEAKKAADEAKMRFAHIDGD----------HLTLLNVYHAFKQN 637

  Fly   667 ESAIRWAKRFHVSLRSLKEIHLLVQELRVRCTHLGLIPFPVNPNQMMD--DREKAIML-KVIIAG 728
            ..:::|.....::.|||.....:.|:|........|      |.:..|  .|:..|.: |.::.|
Human   638 HESVQWCYDNFINYRSLMSADNVRQQLSRIMDRFNL------PRRSTDFTSRDYYINIRKALVTG 696

  Fly   729 AFYP-NYFTRSKESCADTDRNIYQ----TISGHDPCRTVY-------------FTNFKPAYMGEL 775
            .|.. .:..|:.......|..:.|    |:..|.|...:|             .|:.||.::
Human   697 YFMQVAHLERTGHYLTVKDNQVVQLHPSTVLDHKPEWVLYNEFVLTTKNYIRTCTDIKPEWL--- 758

  Fly   776 YTRRIKELFQEVRIPPENMDVTFQEGSQKVFVTFKQDDWIEGSSKYVPVSGRVQSEVY 833
                       |:|.|:..|::          .|.|   .|...:...:..::||:.|
Human   759 -----------VKIAPQYYDMS----------NFPQ---CEAKRQLDRIIAKLQSKEY 792

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spn-E	NP_476741.1	HrpA	113..>697	CDD:224557	178/594 (30%)
spn-E	NP_476741.1	TUDOR	892..1016	CDD:395449
DHX15	NP_001349.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..108
		HrpA	124..763	CDD:224557	201/724 (28%)
		DEAH box	260..263		2/2 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810