DRSC/TRiP Functional Genomics Resources

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Protein Alignment spn-E and DHX9

DIOPT Version :9

Sequence 1:NP_476741.1 Gene:spn-E / 41919 FlyBaseID:FBgn0003483 Length:1434 Species:Drosophila melanogaster
Sequence 2:NP_001348.2 Gene:DHX9 / 1660 HGNCID:2750 Length:1270 Species:Homo sapiens


Alignment Length:778 Identity:242/778 - (31%)
Similarity:384/778 - (49%) Gaps:126/778 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly   107 FNLNRDKNL-SIYAKRE---------EILAAINAHPVVIIKGETGCGKTTQVPQYILDEAYKSGK 161
            :.|.:|.:| :|..:||         |||.||:.:.||||:|.|||||||||||:|||:..::.:
Human   370 YQLEQDHDLQAILQERELLPVKKFESEILEAISQNSVVIIRGATGCGKTTQVPQFILDDFIQNDR 434

  Fly   162 --YCNIVVTQPRRIAAISIANRVCQEREWQQNTVCSFQVG----LHRPNSLEDTRLLYCTTGVLL 220
              .|||||||||||:|:|:|.||..||..:....|.:.|.    |.||::    .:::||.||||
Human   435 AAECNIVVTQPRRISAVSVAERVAFERGEEPGKSCGYSVRFESILPRPHA----SIMFCTVGVLL 495

  Fly   221 NNLINNKTLTHYTHIVLDEVHERDQNMDFLLIVVRRLLATNSRHVKIILMSATIDAKELSDYFTT 285
            ..|  ...:...:|:::||:||||.|.||||:|:|.::.... .|:|:|||||||.....:||..
Human   496 RKL--EAGIRGISHVIVDEIHERDINTDFLLVVLRDVVQAYP-EVRIVLMSATIDTSMFCEYFFN 557

  Fly   286 TNSIPPVITTNHRRKHSIEKFYRD---QLGSII---------WNEEDVGHQQVPEIN-----KHG 333
            .    |:|.. :.|.:.:::::.:   |:...:         ..::|.|.......|     ::|
Human   558 C----PIIEV-YGRTYPVQEYFLEDCIQMTHFVPPPKDKKKKDKDDDGGEDDDANCNLICGDEYG 617

  Fly   334 YRAAVKIIVIIDNMERKAAIQSRQSYDEALRY-GAVLIFLPGIYEIDTMAENLTCMLENDPNI-- 395
            ....:.:..:.:.......|::...|.|.|.. ||||:||||...|.||.::    ||.:|:.  
Human   618 PETRLSMSQLNEKETPFELIEALLKYIETLNVPGAVLVFLPGWNLIYTMQKH----LEMNPHFGS 678

  Fly   396 -KVSIVRCFSLMTPENQRDVFNPPPPGFRKIILTTNIAESSITVPDVSYVIDFCLAKVKVTDTAS 459
             :..|:...|.:..|.||.||:|.|.|..|:||:|||||:|||:.||.||||.|..|||:....:
Human   679 HRYQILPLHSQIPREEQRKVFDPVPVGVTKVILSTNIAETSITINDVVYVIDSCKQKVKLFTAHN 743

  Fly   460 SFSSLRLTWASKANCRQRAGRVGRLRSGRVYRMVNKHFYQREMPEFGIPEMLRLPLQNSVLKAKV 524
            :.::....||||.|..||.||.||:|.|..:.:.::..::| :.....|||.|.||....|..|:
Human   744 NMTNYATVWASKTNLEQRKGRAGRVRPGFCFHLCSRARFER-LETHMTPEMFRTPLHEIALSIKL 807

  Fly   525 LNMGSPVEILALALSPPNLSDIHNTILLLKEVGALYLTVDGIYDPLDGDLTYWGTIMSRLPLDTR 589
            |.:|...:.||.|:.||.|..:......|:|:.||        |..| :||..|.|:::||::.|
Human   808 LRLGGIGQFLAKAIEPPPLDAVIEAEHTLRELDAL--------DAND-ELTPLGRILAKLPIEPR 863

  Fly   590 QSRLIILGYIFNMLEEAIIIAAGLSTPGLFAHEGGRSQLGDSFWMHYIFSDGSGSDLVAIWRVYL 654
            ..:::|:|.||.:.:....|||....|..|.:||.|  ||   ::|..|:....||.||:..|:.
Human   864 FGKMMIMGCIFYVGDAICTIAAATCFPEPFINEGKR--LG---YIHRNFAGNRFSDHVALLSVFQ 923

  Fly   655 TYLNIVENGHDQESAIRWAKRFHVSLRSLK---EIHLLVQELRVRCTHLGLIPFP---------- 706
            .:.:....|  :|:.||:.:...:::.:|:   |..:.::|:.:..      .||          
Human   924 AWDDARMGG--EEAEIRFCEHKRLNMATLRMTWEAKVQLKEILINS------GFPEDCLLTQVFT 980

  Fly   707 -VNPNQMMDDREKAIMLKVIIAGAFYPN--YFTRSKESCADTDRN-IYQTISGHDPCRTVYFTNF 767
             ..|:..:|     :::.::..|. |||  |....::......|| :....|.:.|..:......
Human   981 NTGPDNNLD-----VVISLLAFGV-YPNVCYHKEKRKILTTEGRNALIHKSSVNCPFSSQDMKYP 1039

  Fly   768 KPAYM-GE-LYTRRIKE------------LFQEVRIPPENMDVTFQEGSQKVFVTFKQDDWIE 816
            .|.:: || :.||.|..            ||...::         |...|.|.|    ||||:
Human  1040 SPFFVFGEKIRTRAISAKGMTLVTPLQLLLFASKKV---------QSDGQIVLV----DDWIK 1089

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
spn-ENP_476741.1 HrpA 113..>697 CDD:224557 211/623 (34%)
TUDOR 892..1016 CDD:395449
DHX9NP_001348.2 Interaction with CREBBP. /evidence=ECO:0000269|PubMed:9323138 1..250
DSRM 5..69 CDD:214634
siRNA-binding. /evidence=ECO:0000269|PubMed:23361462, ECO:0007744|PDB:3VYY 5..9
siRNA-binding. /evidence=ECO:0000269|PubMed:23361462, ECO:0007744|PDB:3VYY 53..55
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 83..118
DSRM 181..251 CDD:214634
siRNA-binding. /evidence=ECO:0000269|PubMed:23361462, ECO:0007744|PDB:3VYX 182..186
Interaction with BRCA1. /evidence=ECO:0000269|PubMed:9662397 230..325
siRNA-binding. /evidence=ECO:0000305|PubMed:23361462 234..236
Necessary for interaction with RNA polymerase II holoenzyme. /evidence=ECO:0000269|PubMed:9323138 255..664 105/305 (34%)
Necessary for interaction with H2AX. /evidence=ECO:0000269|PubMed:15613478 313..952 211/614 (34%)
MTAD. /evidence=ECO:0000269|PubMed:11416126 331..380 3/9 (33%)
HrpA 381..1095 CDD:224557 239/767 (31%)
Core helicase. /evidence=ECO:0000305|PubMed:25062910 398..809 156/427 (37%)
DEIH box 511..514 2/2 (100%)
Nuclear localization signal (NLS1). /evidence=ECO:0000255 586..595 0/8 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 588..608 2/19 (11%)
HA2. /evidence=ECO:0000269|PubMed:25062910 831..919 33/101 (33%)
OB-fold. /evidence=ECO:0000269|PubMed:20696886, ECO:0000269|PubMed:25062910, ECO:0000269|PubMed:25149208 958..1074 22/127 (17%)
RGG. /evidence=ECO:0000269|PubMed:10207077, ECO:0000269|PubMed:25062910, ECO:0000269|PubMed:25149208, ECO:0000269|PubMed:9111062 1150..1270
Nuclear localization signal (NLS2). /evidence=ECO:0000269|PubMed:16375861 1155..1173
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1229..1248
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1643
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D278674at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

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