Protein Alignment spn-E and DHX8

DIOPT Version :10

• Sequence 1: NP_476741.1
• Gene: spn-E / 41919
• FlyBaseID: FBgn0003483
• Length: 1434
• Species: Drosophila melanogaster
• Sequence 2: NP_004932.1
• Gene: DHX8 / 1659
• HGNCID: 2749
• Length: 1220
• Species: Homo sapiens
• Alignment Length: 918
• Identity: 229/918 - (24%)
• Similarity: 380/918 - (41%)
• Gaps: 210/918 - (22%)

  Fly     4 EVMDFFDFSKELKRVAAAP---QGYISSDPRLMATKFKSSEVPNRELIGTDYVSKIVAKEKCLLN 65
            :|.|..|...|::.|...|   :|:......:...|...:  |:..|.....:...:|||:..|.
Human   428 KVDDEEDEDLEIELVEEEPPFLRGHTKQSMDMSPIKIVKN--PDGSLSQAAMMQSALAKERRELK 490

  Fly    66 GTL----LNEQPQGKRIRTLDDLDTDDEGEETE--------IRRDDEYYKKFRFN---------- 108
            ...    ::..|.|.....:|.| .|.||.:..        :..|...:||..|.
Human   491 QAQREAEMDSIPMGLNKHWVDPL-PDAEGRQIAANMRGIGMMPNDIPEWKKHAFGGNKASYGKKT 554

  Fly   109 ----LNRDKNLSIYAKREEILAAINAHPVVIIKGETGCGKTTQVPQYILDEAYKS-GKYCNIVVT 168
                |.:.::|.||..:|:::.|::.:.::|:.||||.|||||:.||:.:..|.| ||   |..|
Human   555 QMSILEQRESLPIYKLKEQLVQAVHDNQILIVIGETGSGKTTQITQYLAEAGYTSRGK---IGCT 616

  Fly   169 QPRRIAAISIANRVCQEREWQQNTVCSFQVGLHRPNSLEDTRLLYCTTGVLLNNLINNKTLTHYT 233
            ||||:||:|:|.||.:|..........:.:......|.| |.:.|.|.|:||...:.:..||.|.
Human   617 QPRRVAAMSVAKRVSEEFGCCLGQEVGYTIRFEDCTSPE-TVIKYMTDGMLLRECLIDPDLTQYA 680

  Fly   234 HIVLDEVHERDQNMDFLLIVVRRLLATNSRHVKIILMSATIDAKELSDYFTTTNSIPPVITTNHR 298
            .|:|||.|||..:.|.|..::::.: ...:.:|:|:.|||:||.:.|.||...    |:.|. ..
Human   681 IIMLDEAHERTIHTDVLFGLLKKTV-QKRQDMKLIVTSATLDAVKFSQYFYEA----PIFTI-PG 739

  Fly   299 RKHSIEKFYRDQLGSIIWNEEDVGHQQVPEINKHGYRAAVKIIVIIDNMERKAAIQSRQSYDEAL 363
            |.:.:|         |::.:|       ||.:   |..|..|.|:..::....
Human   740 RTYPVE---------ILYTKE-------PETD---YLDASLITVMQIHLTEPP------------ 773

  Fly   364 RYGAVLIFLPGIYEIDTMAENLTCMLEN-DPNI-KVSIVRCFSLMTPENQRDVFNPPPPGFRKII 426
              |.:|:||.|..||||..|.|...::: .|:: ::.|:..:|.:..|.|..:|:|.|||.||::
Human   774 --GDILVFLTGQEEIDTACEILYERMKSLGPDVPELIILPVYSALPSEMQTRIFDPAPPGSRKVV 836

  Fly   427 LTTNIAESSITVPDVSYVIDFCLAKVKVTDTASSFSSLRLTWASKANCRQRAGRVGRLRSGRVYR 491
            :.|||||:|:|:..:.||:|....|.||.::.:....|.:|..|:|..:|||||.||...|:.||
Human   837 IATNIAETSLTIDGIYYVVDPGFVKQKVYNSKTGIDQLVVTPISQAQAKQRAGRAGRTGPGKCYR 901

  Fly   492 MVNKHFYQREMPEFGIPEMLRLPLQNSVLKAKVLNMGS----------PVEILALALSPPNLSDI 546
            :..:..|:.||....:||:.|..|.::||..|.:.:..          |:|.|..|:..
Human   902 LYTERAYRDEMLTTNVPEIQRTNLASTVLSLKAMGINDLLSFDFMDAPPMETLITAMEQ------ 960

  Fly   547 HNTILLLKEVGALYLTVDGIYDPLDGDLTYWGTIMSRLPLDTRQSRLIILGYIFNMLEEAIIIAA 611
                  |..:|||        |. :|.||..|..|:..||:....:::|:.......||.:.|.:
Human   961 ------LYTLGAL--------DD-EGLLTRLGRRMAEFPLEPMLCKMLIMSVHLGCSEEMLTIVS 1010

  Fly   612 GLSTPGLFAHEGGRSQLGDSFWMHYIFSDGSGSDLVAIWRVYLTYLNIVENGHDQESAIRWAKRF 676
            .||...:|.....:..|.|.....:..::|.          :||.|.:..:..:.:.:..|....
Human  1011 MLSVQNVFYRPKDKQALADQKKAKFHQTEGD----------HLTLLAVYNSWKNNKFSNPWCYEN 1065

  Fly   677 HVSLRSLKEIHLLVQELRVRCTHLGLIPFPVNPNQMMDDREKAIMLKVIIAGAFYPNYFTRSKES 741
            .:..|||:.    .|::|.:.  ||::           ||.|   |.|:               |
Human  1066 FIQARSLRR----AQDIRKQM--LGIM-----------DRHK---LDVV---------------S 1095

  Fly   742 CADTDRNIYQTI-SGHDPCRTVYFTNFKPAYMGELYTRRIKELFQEVRIPPENMDVTFQEGSQKV 805
            |..:...:.:.| ||       :|.|.......|.|...|.:  |.|.|.|          |..:
Human  1096 CGKSTVRVQKAICSG-------FFRNAAKKDPQEGYRTLIDQ--QVVYIHP----------SSAL 1141

  Fly   806 FVTFKQDDWIEGSSKYVPVSGRVQSEVYKAVMMRQNRVERPIHIMNPSAFMSYVQQRGIGDVIEG 870
            |  .:|.:|:                ||..:::......|.:..::|
Human  1142 F--NRQPEWV----------------VYHELVLTTKEYMREVTTIDP------------------ 1170

  Fly   871 RWIPPTKP 878
            ||:....|
Human  1171 RWLVEFAP 1178

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spn-E	NP_476741.1	HrpA	114..>697	CDD:441249	171/595 (29%)
		DEXHc_TDRD9	115..295	CDD:350746	65/180 (36%)
		TUDOR	892..1016	CDD:425754
DHX8	NP_004932.1	GH2-like_DHX8	25..92	CDD:409668
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	153..266
		S1_DHX8_helicase	265..343	CDD:240189
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	337..372
		HrpA	556..>1187	CDD:441249	204/787 (26%)
		DEAH box	685..688		2/2 (100%)