DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spn-E and DHX8

DIOPT Version :9

Sequence 1:	NP_476741.1	Gene:	spn-E / 41919	FlyBaseID:	FBgn0003483	Length:	1434	Species:	Drosophila melanogaster
Sequence 2:	NP_004932.1	Gene:	DHX8 / 1659	HGNCID:	2749	Length:	1220	Species:	Homo sapiens

Alignment Length:	918	Identity:	229/918 - (24%)
Similarity:	380/918 - (41%)	Gaps:	210/918 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 EVMDFFDFSKELKRVAAAP---QGYISSDPRLMATKFKSSEVPNRELIGTDYVSKIVAKEKCLLN 65
            :|.|..|...|::.|...|   :|:......:...|...:  |:..|.....:...:|||:..|.
Human   428 KVDDEEDEDLEIELVEEEPPFLRGHTKQSMDMSPIKIVKN--PDGSLSQAAMMQSALAKERRELK 490

  Fly    66 GTL----LNEQPQGKRIRTLDDLDTDDEGEETE--------IRRDDEYYKKFRFN---------- 108
            ...    ::..|.|.....:|.| .|.||.:..        :..|...:||..|.
Human   491 QAQREAEMDSIPMGLNKHWVDPL-PDAEGRQIAANMRGIGMMPNDIPEWKKHAFGGNKASYGKKT 554

  Fly   109 ----LNRDKNLSIYAKREEILAAINAHPVVIIKGETGCGKTTQVPQYILDEAYKS-GKYCNIVVT 168
                |.:.::|.||..:|:::.|::.:.::|:.||||.|||||:.||:.:..|.| ||   |..|
Human   555 QMSILEQRESLPIYKLKEQLVQAVHDNQILIVIGETGSGKTTQITQYLAEAGYTSRGK---IGCT 616

  Fly   169 QPRRIAAISIANRVCQEREWQQNTVCSFQVGLHRPNSLEDTRLLYCTTGVLLNNLINNKTLTHYT 233
            ||||:||:|:|.||.:|..........:.:......|.| |.:.|.|.|:||...:.:..||.|.
Human   617 QPRRVAAMSVAKRVSEEFGCCLGQEVGYTIRFEDCTSPE-TVIKYMTDGMLLRECLIDPDLTQYA 680

  Fly   234 HIVLDEVHERDQNMDFLLIVVRRLLATNSRHVKIILMSATIDAKELSDYFTTTNSIPPVITTNHR 298
            .|:|||.|||..:.|.|..::::.: ...:.:|:|:.|||:||.:.|.||...    |:.|. ..
Human   681 IIMLDEAHERTIHTDVLFGLLKKTV-QKRQDMKLIVTSATLDAVKFSQYFYEA----PIFTI-PG 739

  Fly   299 RKHSIEKFYRDQLGSIIWNEEDVGHQQVPEINKHGYRAAVKIIVIIDNMERKAAIQSRQSYDEAL 363
            |.:.:|         |::.:|       ||.:   |..|..|.|:..::....
Human   740 RTYPVE---------ILYTKE-------PETD---YLDASLITVMQIHLTEPP------------ 773

  Fly   364 RYGAVLIFLPGIYEIDTMAENLTCMLEN-DPNI-KVSIVRCFSLMTPENQRDVFNPPPPGFRKII 426
              |.:|:||.|..||||..|.|...::: .|:: ::.|:..:|.:..|.|..:|:|.|||.||::
Human   774 --GDILVFLTGQEEIDTACEILYERMKSLGPDVPELIILPVYSALPSEMQTRIFDPAPPGSRKVV 836

  Fly   427 LTTNIAESSITVPDVSYVIDFCLAKVKVTDTASSFSSLRLTWASKANCRQRAGRVGRLRSGRVYR 491
            :.|||||:|:|:..:.||:|....|.||.::.:....|.:|..|:|..:|||||.||...|:.||
Human   837 IATNIAETSLTIDGIYYVVDPGFVKQKVYNSKTGIDQLVVTPISQAQAKQRAGRAGRTGPGKCYR 901

  Fly   492 MVNKHFYQREMPEFGIPEMLRLPLQNSVLKAKVLNMGS----------PVEILALALSPPNLSDI 546
            :..:..|:.||....:||:.|..|.::||..|.:.:..          |:|.|..|:..
Human   902 LYTERAYRDEMLTTNVPEIQRTNLASTVLSLKAMGINDLLSFDFMDAPPMETLITAMEQ------ 960

  Fly   547 HNTILLLKEVGALYLTVDGIYDPLDGDLTYWGTIMSRLPLDTRQSRLIILGYIFNMLEEAIIIAA 611
                  |..:|||        |. :|.||..|..|:..||:....:::|:.......||.:.|.:
Human   961 ------LYTLGAL--------DD-EGLLTRLGRRMAEFPLEPMLCKMLIMSVHLGCSEEMLTIVS 1010

  Fly   612 GLSTPGLFAHEGGRSQLGDSFWMHYIFSDGSGSDLVAIWRVYLTYLNIVENGHDQESAIRWAKRF 676
            .||...:|.....:..|.|.....:..::|.          :||.|.:..:..:.:.:..|....
Human  1011 MLSVQNVFYRPKDKQALADQKKAKFHQTEGD----------HLTLLAVYNSWKNNKFSNPWCYEN 1065

  Fly   677 HVSLRSLKEIHLLVQELRVRCTHLGLIPFPVNPNQMMDDREKAIMLKVIIAGAFYPNYFTRSKES 741
            .:..|||:.    .|::|.:.  ||::           ||.|   |.|:               |
Human  1066 FIQARSLRR----AQDIRKQM--LGIM-----------DRHK---LDVV---------------S 1095

  Fly   742 CADTDRNIYQTI-SGHDPCRTVYFTNFKPAYMGELYTRRIKELFQEVRIPPENMDVTFQEGSQKV 805
            |..:...:.:.| ||       :|.|.......|.|...|.:  |.|.|.|          |..:
Human  1096 CGKSTVRVQKAICSG-------FFRNAAKKDPQEGYRTLIDQ--QVVYIHP----------SSAL 1141

  Fly   806 FVTFKQDDWIEGSSKYVPVSGRVQSEVYKAVMMRQNRVERPIHIMNPSAFMSYVQQRGIGDVIEG 870
            |  .:|.:|:                ||..:::......|.:..::|
Human  1142 F--NRQPEWV----------------VYHELVLTTKEYMREVTTIDP------------------ 1170

  Fly   871 RWIPPTKP 878
            ||:....|
Human  1171 RWLVEFAP 1178

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spn-E	NP_476741.1	HrpA	113..>697	CDD:224557	171/596 (29%)
spn-E	NP_476741.1	TUDOR	892..1016	CDD:395449
DHX8	NP_004932.1	GH2-like_DHX8	25..92	CDD:409668
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	153..266
		RpsA	<263..422	CDD:223613
		S1_DHX8_helicase	265..343	CDD:240189
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	337..372
		HrpA	557..1219	CDD:224557	204/786 (26%)
		DEAH box	685..688		2/2 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810