Protein Alignment spn-E and DQX1

DIOPT Version :10

• Sequence 1: NP_476741.1
• Gene: spn-E / 41919
• FlyBaseID: FBgn0003483
• Length: 1434
• Species: Drosophila melanogaster
• Sequence 2: NP_598376.2
• Gene: DQX1 / 165545
• HGNCID: 20410
• Length: 717
• Species: Homo sapiens
• Alignment Length: 770
• Identity: 165/770 - (21%)
• Similarity: 280/770 - (36%)
• Gaps: 194/770 - (25%)

  Fly   101 YYKKFRFNLNRDKNLSIYAKREEILAAINAHP--VVIIKGETGCGKTTQVPQ----YILDEAYKS 159
            ||:.    |.:.:.|.|:|.|...|..:.::|  ||::.||.|.||:||:||    :.|...::.
Human    35 YYEL----LKQRQALPIWAARFTFLEQLESNPTGVVLVSGEPGSGKSTQIPQWCAEFALARGFQK 95

  Fly   160 GKYCNIVVTQPRRIAAISIANRVCQEREWQQNTVCSFQVGLHRPNSLED-----TRLLYCTTGVL 219
            |:   :.||||..:||.|:|.||..|    .:.....:||...|.  ||     |.|.:|...:|
Human    96 GQ---VTVTQPYPLAARSLALRVADE----MDLTLGHEVGYSIPQ--EDCTGPNTLLRFCWDRLL 151

  Fly   220 LNNLINNKTLTHYTHIVLDEVHERDQNMDFLLIVVRRLLATNSRHVKIILMSATIDAKELSDYFT 284
            |..:.:.:....:..:||||..||....|.|               :.:|..|.::        .
Human   152 LQEVASTRGTGAWGVLVLDEAQERSVASDSL---------------QGLLQDARLE--------K 193

  Fly   285 TTNSIPPVITTNHRRKHSIEKFYRDQLGSIIWNEEDVGHQQVPEINKHGYRAAVKIIVIIDNMER 349
            ....:..|:.|:...:..:..|         |....:.|  :|  .:.|.|.:......|.....
Human   194 LPGDLRVVVVTDPALEPKLRAF---------WGNPPIVH--IP--REPGERPSPIYWDTIPPDRV 245

  Fly   350 KAAIQSRQSYDEALRYGAVLIFLPGIYEIDTMAENLTCMLEN-------------DPNIKVSIVR 401
            :||.|:..........|.||:|||...||....|:|:..:|:             .|:...::..
Human   246 EAACQAVLELCRKELPGDVLVFLPSEEEISLCCESLSREVESLLLQGLPPRVLPLHPDCGRAVQA 310

  Fly   402 CFSLMTPENQRDVFNPPPPGFRKIILTTNIAESSITVPDVSYVIDFCLAKVKVTD--TASSFSSL 464
            .:..|..              ||:::|..:|:.|.::|.:.:|||..|....|.:  ..:.|..|
Human   311 VYEDMDA--------------RKVVVTHWLADFSFSLPSIQHVIDSGLELRSVYNPRIRAEFQVL 361

  Fly   465 RLTWASKANCRQRAGRVGRLRSGRVYRMVNKHFYQREMPEFGIPEMLRLPLQNSVLKAKVLNMGS 529
            |.  .||.....|..|......|....:..|.|.:.|.|....|.:....|.:.||..|...:..
Human   362 RP--ISKCQAEARRLRARGFPPGSCLCLYPKSFLELEAPPLPQPRVCEENLSSLVLLLKRRQIAE 424

  Fly   530 PVEILALALSPPNLSDIHNTILLLKEVGALYLTVDGIYDPLDGDLTYWGTIMSRLPLDTRQSRLI 594
            |.|...|....|..     .:..|:::..|....|      ||||:..|.|:|..||....::.:
Human   425 PGECHFLDQPAPEA-----LMQALEDLDYLAALDD------DGDLSDLGVILSEFPLAPELAKAL 478

  Fly   595 ILGYIFNMLEEAIIIAA------GLSTPGLFAHEGGRSQLGDSFWMHYIFSDGSGSDLVAIWRVY 653
            :....|:.::|.:.:||      |.:.|.|.|.|....:..:       .:||..|.|:.::..:
Human   479 LASCEFDCVDEMLTLAAMLTAAPGFTRPPLSAEEAALRRALE-------HTDGDHSSLIQVYEAF 536

  Fly   654 LTYLNIVENGHD----QESAIRWAKRFHVSLRSLKEIHLL---VQELRVRCTHLGLIPFPVNPNQ 711
                  :::|.|    |...:.||        :|.:.|.|   :.||..|      |..|::...
Human   537 ------IQSGADEAWCQARGLNWA--------ALCQAHKLRGELLELMQR------IELPLSLPA 581

  Fly   712 MMDDREKAIMLKVIIAGAFYP---------NY--------------------------------- 734
            ...::.:..:.|.:::|.|..         ||
Human   582 FGSEQNRRDLQKALVSGYFLKVARDTDGTGNYLLLTHKHVAQLSSYCCYRSRRAPARPPPWVLYH 646

  Fly   735 -FTRSKESCADTDRNIYQTISGHDPCRTVYFTNFKPAYMGELYTRRIKELFQEVR 788
             ||.||::|       ...:|...|...|...  .|.::..|.....::|..::|
Human   647 NFTISKDNC-------LSIVSEIQPQMLVELA--PPYFLSNLPPSESRDLLNQLR 692

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spn-E	NP_476741.1	HrpA	114..>697	CDD:441249	142/621 (23%)
		DEXHc_TDRD9	115..295	CDD:350746	51/190 (27%)
		TUDOR	892..1016	CDD:425754
DQX1	NP_598376.2	HrpA	44..>615	CDD:441249	150/669 (22%)
		DEXQc_DQX1	45..224	CDD:350744	55/221 (25%)
		DEAQ box. /evidence=ECO:0000305|PubMed:11353393	170..173		2/2 (100%)
		OB_NTP_bind	591..674	CDD:400182	13/91 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	694..717