DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spn-E and TDRD9

DIOPT Version :9

Sequence 1:	NP_476741.1	Gene:	spn-E / 41919	FlyBaseID:	FBgn0003483	Length:	1434	Species:	Drosophila melanogaster
Sequence 2:	NP_694591.2	Gene:	TDRD9 / 122402	HGNCID:	20122	Length:	1382	Species:	Homo sapiens

Alignment Length:	1324	Identity:	441/1324 - (33%)
Similarity:	705/1324 - (53%)	Gaps:	144/1324 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 NLSIYAKREEILAAINAHPVVIIKGETGCGKTTQVPQYILDEAYKSGKYCNIVVTQPRRIAAISI 178
            :|.|...:||:::.|.::.||||.|.||.||:||:||||||...:...||:|||||||:|.|.||
Human   131 DLPISRYKEEVVSLIESNSVVIIHGATGSGKSTQLPQYILDHYVQRSAYCSIVVTQPRKIGASSI 195

  Fly   179 ANRVCQEREWQQNTVCSFQVGLHRPNSLEDTRLLYCTTGVLLNNLINNKTLTHYTHIVLDEVHER 243
            |..:.:||.|....|..:||||.: .:.|||||:|.||||||..:::.|:|..:|||::||||||
Human   196 ARWISKERAWTLGGVVGYQVGLEK-IATEDTRLIYMTTGVLLQKIVSAKSLMEFTHIIIDEVHER 259

  Fly   244 DQNMDFLLIVVRRLLATNSRHVKIILMSATIDAKELSDYFT--TTNSI-PPVITTNHRRKHSIEK 305
            .:.|||||:|||:||.||||.||::||||||..||.:|||.  ..|.: |..|.....:.||:|:
Human   260 TEEMDFLLLVVRKLLRTNSRFVKVVLMSATISCKEFADYFAVPVQNKMNPAYIFEVEGKPHSVEE 324

  Fly   306 FYRDQLGSIIWNEEDVGHQQV-------PEINKHGYRAAVKIIVIIDNMERKAAIQSRQSYDEA- 362
            :|.:.|       |.:.|.::       |.|.|..|..||.:|.:.|:::.|.:  ..:::..|
Human   325 YYLNDL-------EHIHHSKLSPHLLEEPVITKDIYEVAVSLIQMFDDLDMKES--GNKAWSGAQ 380

  Fly   363 --LRYGAVLIFLPGIYEIDTMAENLTCMLENDPNIKVSIVRCFSLMTPENQRDVFNPPPPGFRKI 425
              |...:||:||||:.||:.|.|.||.::..    ::.:....|.:..|.|.:||..|.||:|||
Human   381 FVLERSSVLVFLPGLGEINYMHELLTSLVHK----RLQVYPLHSSVALEEQNNVFLSPVPGYRKI 441

  Fly   426 ILTTNIAESSITVPDVSYVIDFCLAKVKVTDTASSFSSLRLTWASKANCRQRAGRVGRLRSGRVY 490
            ||:|||||||:|||||.|||||||.:..|.|..:::.||||:||||.:|.||.||.||:..|..|
Human   442 ILSTNIAESSVTVPDVKYVIDFCLTRTLVCDEDTNYQSLRLSWASKTSCNQRKGRAGRVSRGYCY 506

  Fly   491 RMVNKHFYQREMPEFGIPEMLRLPLQNSVLKAKVLNMGSPVEILALALSPPNLSDIHNTILLLKE 555
            |:|:|.|:...:|:..:|||||.||.:::||.|:|:||.|..:||.|||||.||||..|||||||
Human   507 RLVHKDFWDNSIPDHVVPEMLRCPLGSTILKVKLLDMGEPRALLATALSPPGLSDIERTILLLKE 571

  Fly   556 VGALYLTVDGIYD---PLDGDLTYWGTIMSRLPLDTRQSRLIILGYIFNMLEEAIIIAAGLSTPG 617
            |||  |.|.|..:   |.||:||:.|.::::||::.:..:||:||::|..|:|.:||||.||...
Human   572 VGA--LAVSGQREDENPHDGELTFLGRVLAQLPVNQQLGKLIVLGHVFGCLDECLIIAAALSLKN 634

  Fly   618 LFA-----H-EGGRSQLGDSFWMHYIFSDGSGSDLVAIWRVYLTYLNIVENGHDQ--ESAIRWAK 674
            .||     | :|.|:::.        ||..|.||.:|:...:.|:....:.|..:  :..:.|.:
Human   635 FFAMPFRQHLDGYRNKVN--------FSGSSKSDCIALVEAFKTWKACRQTGELRYPKDELNWGR 691

  Fly   675 RFHVSLRSLKEIHLLVQELRVRCTHLGLIPFPVNPNQMMDDRE----KAIMLKVIIAGAFYPNYF 735
            ..::.::.::|:..|.:||:.|.:...:   .|:..:.:.|:|    :..:|:|::|||||||||
Human   692 LNYIQIKRIREVAELYEELKTRISQFNM---HVDSRRPVMDQEYIYKQRFILQVVLAGAFYPNYF 753

  Fly   736 TRSKESCADTDRNIYQTISGHDPCRTVYFTNFKPAYMGELYTRRIKELFQEVRIPPENMDVTFQE 800
            |..:..    :....:.::|.||..||...:..|  .|.||.::::.||::.   .:...:.| :
Human   754 TFGQPD----EEMAVRELAGKDPKTTVVLKHIPP--YGFLYYKQLQSLFRQC---GQVKSIVF-D 808

  Fly   801 GSQKVFVTFKQDDWIEGSSKYVPVSGRVQSEVYKAVMMRQNRVERPIHIMNPSAFMSYVQQRGIG 865
            |: |.||.|.::.  ....|.:|.       ||.|:.|.|.:|...:.:.:.......||...:.
Human   809 GA-KAFVEFSRNP--TERFKTLPA-------VYMAIKMSQLKVSLELSVHSAEEIEGKVQGMNVS 863

  Fly   866 DVIEGRWIPPTKPLNVELLAL--------PSVFDKTISGSITCIVNCGKFFFQPQSFEECIRNMS 922
            .:...|.....:...|:.:.:        .:|.|..::..:|.:|..|.|:  ....:|   |.|
Human   864 KLRNTRVNVDFQKQTVDPMQVSFNTSDRSQTVTDLLLTIDVTEVVEVGHFW--GYRIDE---NNS 923

  Fly   923 EIFNAPQQLRNYVT--------NASAIAKGMMVLAKRDSYFQRATVIRPENQSNRQPMFYVRFID 979
            ||........|.:|        :...:.........:..|| ||.|:.....|..     |.|:|
Human   924 EILKKLTAEINQLTLVPLPTHPHPDLVCLAPFADFDKQRYF-RAQVLYVSGNSAE-----VFFVD 982

  Fly   980 YGNCTLLPMQLMRLMPRELTEQYGDLPPRVFECRLAMVQPS--SVVSGNNRWSTAANDMLKT-VA 1041
            |||.:.:.:.|:    .|:..|:.:||.:..|.::..::||  |:|.|.: ||..|:....: |:
Human   983 YGNKSHVDLHLL----MEIPCQFLELPFQALEFKICKMRPSAKSLVCGKH-WSDGASQWFASLVS 1042

  Fly  1042 QCGLIDIEVYSLFNNVAAVLIHMRDGI-----INDKLVELMLCRRSDEDYMSRKDHD-FRLRRQE 1100
            .|.|: ::|:|:.::|..|.::...|:     |.|.|::......::|.|.|::.|: .:....:
Human  1043 GCTLL-VKVFSVVHSVLHVDVYQYSGVQDAINIRDVLIQQGYAELTEESYESKQSHEVLKGLFSK 1106

  Fly  1101 SARNL---STAQRQQINEEYLRSCQLP--QDHDLPPPPLEKCKTVVMLKGPNSPLECTMRSITRV 1160
            |..|:   |.....:.:|:||....|.  ..:.|..|   .||  ..|.||.:|.|....|:||:
Human  1107 SVENMTDGSVPFPMKDDEKYLIRILLESFSTNKLGTP---NCK--AELHGPFNPYELKCHSLTRI 1166

  Fly  1161 GLSKRVNIDHLSVNALLLDADPQDHHDHLIVAHEIAESRNGQTLTARGTTLMPNVQGFGALMVML 1225
            ...:.|.|:..|:|::::...|:|.|..::||..::.:..|.|:..|.|:|||::.|..||:.||
Human  1167 SKFRCVWIEKESINSVIISDAPEDLHQRMLVAASLSINATGSTMLLRETSLMPHIPGLPALLSML 1231

  Fly  1226 FSPTMQLKCNKEGTSYVSVLGGLGCDPDTNEPYFAEHDVLINLDVNILEDDVILINQIRYYIDSV 1290
            |:|.::|:.::.|..|..||.|||.:|.|......|||:.:..||....:||:.:|.:|..|:.:
Human  1232 FAPVIELRIDQNGKYYTGVLCGLGWNPATGASILPEHDMELAFDVQFSVEDVVEVNILRAAINKL 1296

  Fly  1291 FFNFKEENNPAVSVNERVSIYTQLRSLINR----LLC--KDRRYIERNMSNADFEW-ETNPELPL 1348
            ..:  ..|.......|||:   ||:.:..:    |.|  |.|..|........:|| :.:|:|.:
Human  1297 VCD--GPNGCKCLGPERVA---QLQDIARQKLLGLFCQSKPREKIVPKWHEKPYEWNQVDPKLVM 1356

  Fly  1349 P----NEPFGKRA-IFPMHSLTEL 1367
            .    ....||.. ::.:|.|..|
Human  1357 EQADRESSRGKNTFLYQLHKLVVL 1380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spn-E	NP_476741.1	HrpA	113..>697	CDD:224557	260/606 (43%)
spn-E	NP_476741.1	TUDOR	892..1016	CDD:395449	29/131 (22%)
TDRD9	NP_694591.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	36..62
		HrpA	132..>716	CDD:224557	261/607 (43%)
		DEXDc	149..290	CDD:238005	82/141 (58%)
		DEAH box. /evidence=ECO:0000250\|UniProtKB:Q14BI7	254..257		2/2 (100%)
		Helicase_C	383..500	CDD:278689	61/120 (51%)
		HA2	588..665	CDD:214852	31/84 (37%)
		TUDOR	904..1013	CDD:278965	29/123 (24%)
		TUDOR	949..996	CDD:119391	13/56 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157025
Domainoid	1	1.000	176	1.000	Domainoid score	I3642
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H14311
Inparanoid	1	1.050	603	1.000	Inparanoid score	I949
Isobase	1	0.950	-	0	Normalized mean entropy	S5414
OMA	1	1.010	-	-		QHG47461
OrthoDB	1	1.010	-	-		D253470at33208
OrthoFinder	1	1.000	-	-		FOG0008277
OrthoInspector	1	1.000	-	-		oto89325
orthoMCL	1	0.900	-	-		OOG6_106475
Panther	1	1.100	-	-	LDO	PTHR18934
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4766
SonicParanoid	1	1.000	-	-		X6258
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750