DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spn-E and Dhx57

DIOPT Version :9

Sequence 1:	NP_476741.1	Gene:	spn-E / 41919	FlyBaseID:	FBgn0003483	Length:	1434	Species:	Drosophila melanogaster
Sequence 2:	NP_001157231.1	Gene:	Dhx57 / 106794	MGIID:	2147067	Length:	1388	Species:	Mus musculus

Alignment Length:	982	Identity:	264/982 - (26%)
Similarity:	436/982 - (44%)	Gaps:	220/982 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 ISSDPRLMATKFKSSEVPNRELIGTDYVSKIVAKEKCLLNGTLLNEQPQGKRIRTLDDLDTDDEG 90
            :.|:.|:....::...||:                    |..|.|:..:|:|:..|::...:|||
Mouse   442 VPSETRISKPAYRKPVVPS--------------------NTFLSNQMLEGERLSELEEDADEDEG 486

  Fly    91 EETEIRRDDEY-------YKKF-------------------------RFN--LNRDKNLSIYAKR 121
            ..:.|..::.|       ||::                         :|:  |...:.|..:.:|
Mouse   487 PASIIVENESYVNLKKRSYKRYDRPAKSLFAENSKICRQFQMKQASRQFHAILQERQLLPAWEER 551

  Fly   122 EEILAAINAHPVVIIKGETGCGKTTQVPQYILDEAYKS--GKYCNIVVTQPRRIAAISIANRVCQ 184
            |.||..::.|.||:|.|.||||||||:||:|||.:...  .:..||:.||||||:|||:|.||.:
Mouse   552 ETILKLLSKHQVVVISGMTGCGKTTQIPQFILDNSLNGPPERVANIICTQPRRISAISVAERVAK 616

  Fly   185 EREWQQNTVCSFQVGLHRPNSLEDTRLLYCTTGVLLNNLINNKTLTHYTHIVLDEVHERDQNMDF 249
            ||..:......:|:.|....| ..||||||||||||..|..:.||...|||::||||||.:..||
Mouse   617 ERAERVGLTVGYQIRLESVKS-SATRLLYCTTGVLLRRLEGDATLQGVTHIIVDEVHERTEESDF 680

  Fly   250 LLIVVRRLLATNSRHVKIILMSATIDAKELSDYFTTTNSIPPVIT-------------------- 294
            ||:|::.::...:. :::||||||:||...|.||    |..||||
Mouse   681 LLLVLKDIVMQRAT-LQVILMSATLDAGLFSKYF----SYCPVITIPGRAFPVDQFFLEDALAVT 740

  Fly   295 -----------------------TNHRR--KHSIEKFYRDQLGSIIWNEEDVGHQQVPE------ 328
                                   ..|.|  :..:|:..|  |...:.:||:.....:|:
Mouse   741 RYVLQDGSPYMRSMKQIAKEKLKARHNRTAQEEVEEDLR--LSLHLQDEEESVKDTIPDQQLDFK 803

  Fly   329 ---INKHGY-RAAVKIIVIID----NMERKAA-----IQSRQSYDEALRYGAVLIFLPGIYEIDT 380
               |...|. ::.:|.:.::|    |:|...|     :..:.:|..    ||||:||||:.||..
Mouse   804 QLLIRYKGVSKSVIKTMSVMDFEKVNLELIEALLEWIVDGKHAYPP----GAVLVFLPGLAEIKM 864

  Fly   381 MAENL--TCMLENDPNIKVSIVRCFSLMTPENQRDVFNPPPPGFRKIILTTNIAESSITVPDVSY 443
            :.|.|  ..:..|..:.:..|....|.::.|.|:.||..||.|..|||::|||||:|||:.||.|
Mouse   865 LYEQLQSNSLFNNRRSHRCVIHPLHSSLSSEEQQAVFVKPPMGVTKIIISTNIAETSITIDDVVY 929

  Fly   444 VIDFCLAKVKVTDTASSFSSLRLTWASKANCRQRAGRVGRLRSGRVYRMVNKHFYQREMPEFGIP 508
            |||....|.|..|......||..|:.|:||..||.||.||:.||..:.:...|.|..::.:..:|
Mouse   930 VIDSGKMKEKRYDAGKGMESLEDTFVSQANALQRKGRAGRVASGVCFHLFTSHHYNHQLLKQQLP 994

  Fly   509 EMLRLPLQNSVLKAKVLNMGSP---VEILALALSPPNLSDIHNTILLLKEVGALYLTVDGIYDPL 570
            |:.|:||:...|:.|:|.|.|.   ..:.:..:.||::..:..:.:.|:::|||        .|
Mouse   995 EIQRVPLEQLCLRIKILEMFSTHNLQSVFSRLIEPPHIDSLRASKVRLRDLGAL--------TP- 1050

  Fly   571 DGDLTYWGTIMSRLPLDTRQSRLIILGYIFNMLEEAIIIAAGLSTPGLFAHEGGRSQLGDSFWMH 635
            |..||..|..::.||:|.|..:|::||.||..|:.|:.|||.|:....|.....:.:..:...:.
Mouse  1051 DEKLTPLGYHLASLPVDVRIGKLMLLGSIFRCLDPALTIAASLAFKSPFVSPWDKKEEANQKKLE 1115

  Fly   636 YIFSDGSGSDLVAIWRVYLTY-LNIVENGHDQESAIRWAKRFHVSLRSLKEIHLLVQELRVRCTH 699
            :.|::   ||.:|:...|..: |:..|:.   .::..:.::..:|.|:|:|:..|.::.....:.
Mouse  1116 FAFAN---SDYLALLCAYKGWQLSTKESA---RASYNYCRQNFLSGRTLQEMASLKRQFTELLSD 1174

  Fly   700 LGLIPFPVNPNQ----------MMD--------DREKAIMLKVIIAGAFYPNYF----------- 735
            :|.:...:...:          ::|        :.|...::..::..|.|||..
Mouse  1175 IGFVKEGLRAKEIEKRAQGGDGVLDATGEEANTNAENPKLISAVLCAALYPNVVQVKTPEGKFQK 1239

  Fly   736 ---------TRSKESCADTDRNIYQTISGHDPCRTVYFTNFKPAYMGELYTRRIK---------- 781
                     .:|.|....|..:.|..|  |.........:|...|:  ||..:||
Mouse  1240 TSSGVVRLQPKSAELKFVTKNDGYVHI--HPSSVNYQVRHFDSPYL--LYHEKIKTSRVFIRDCS 1300

  Fly   782 --ELFQEVRIPPENMDVTFQEGSQKVFVTFKQDDWIEGSSKYVPVSGRVQSEVYKAV-----MMR 839
              .::..|......::|..|.|:   ||....|.||    ::|..|.:| :|:.|.:     .:.
Mouse  1301 MVSVYPLVLFGGGQVNVQLQRGA---FVVSLDDGWI----RFVAASHQV-AELVKELRCELDQLL 1357

  Fly   840 QNRVERP 846
            |::::.|
Mouse  1358 QDKIKNP 1364

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spn-E	NP_476741.1	HrpA	113..>697	CDD:224557	210/655 (32%)
spn-E	NP_476741.1	TUDOR	892..1016	CDD:395449
Dhx57	NP_001157231.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..107
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	121..154
		UBA_DHX57	181..218	CDD:270502
		RWD	246..419	CDD:368608
		HrpA	501..1298	CDD:224557	233/827 (28%)
		DEVH box	669..672		2/2 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D278674at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820