DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spn-E and dhx37

DIOPT Version :9

Sequence 1:	NP_476741.1	Gene:	spn-E / 41919	FlyBaseID:	FBgn0003483	Length:	1434	Species:	Drosophila melanogaster
Sequence 2:	XP_005172500.1	Gene:	dhx37 / 100009635	ZFINID:	ZDB-GENE-030131-4505	Length:	1153	Species:	Danio rerio

Alignment Length:	1019	Identity:	232/1019 - (22%)
Similarity:	388/1019 - (38%)	Gaps:	285/1019 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 KRIRTLDDLDTDDEGEETEIRRDD--------------------------------EYYKKFRFN 108
            ||.|..|:.:.::|.|.:|...||                                |..|....:
Zfish   153 KRRREADEEEEENESEMSESSEDDDDSEESDSSEEEKEKISEEKHTEEQQQQQVLKEETKPKEAD 217

  Fly   109 LNRDK-----------------------------NLSIYAKREEILAAINAHPVVIIKGETGCGK 144
            :..:|                             .|.:.|:.:.|:.|:..|..|::.||||.||
Zfish   218 MKEEKKAETWTKEDCKPAVFIPVERLPEIQEARLRLPVLAEEQIIMEAVKDHECVVLCGETGSGK 282

  Fly   145 TTQVPQYILDEAYKSGKYCNIVVTQPRRIAAISIANRVCQEREWQQNTVCSFQVGLHRPNSLEDT 209
            ||||||::.:..:.|.... |.||:|||:||||:::||..|.......| |:|: .:..|..|:|
Zfish   283 TTQVPQFLYEAGFASSGGI-IGVTEPRRVAAISMSHRVATEMNLSSGVV-SYQI-RYEGNVTENT 344

  Fly   210 RLLYCTTGVLLNNLINNKTLTHYTHIVLDEVHERDQNMDFLLIVVRRLLATNSRH---VKIILMS 271
            ::...|.||||..:..:..|..|:.|::||.|||....|.|:.::.|::...::.   :|:|:||
Zfish   345 KIKVMTDGVLLKEIQRDFLLQKYSVIIIDEAHERSVYTDILIGLLSRIVPLRNKKGLPMKLIIMS 409

  Fly   272 ATIDAKELSDYFTTTNSIPPVI--------TTNHRRKHSIEKFYRDQL--------------GSI 314
            ||:..::.::.....:|.||||        .|.|..|.:....|..:.              |.:
Zfish   410 ATLRVEDFTENKRLFSSPPPVIKVEARQFAVTVHFNKRTPMDDYTGETFRKICKIHRMLPPGGIL 474

  Fly   315 IW----------------------NEEDVGHQQVPEINKHGYRAAVKIIVIID-NMERKAAI--- 353
            ::                      |.|.....:..|..|...||..|.:.:.. |::..:|:
Zfish   475 VFLTGQAEVHSVCRRLRKAFPYKPNREHTDMMETEEDLKKSKRAKKKNVSLPRINLDNYSALPVD 539

  Fly   354 ---QSRQSYDEALRYGAVLIFLPGIYEIDTMAENLTCML----------ENDPNIKVSIVRCFSL 405
               :.||:               ||.|.|....:|...|          :.||:|.:.::..:||
Zfish   540 EGDEDRQA---------------GIDEDDGEGSDLELELGDHPDTDHEEKADPSIPLYVLPLYSL 589

  Fly   406 MTPENQRDVFNPPPPGFRKIILTTNIAESSITVPDVSYVIDFCLAKVKVTDTASSFSSLRLTWAS 470
            :.||.|..||.|||.|.|..::.||:||:|:|:|.:.||:|....|.:..|..:..||.::||.|
Zfish   590 LAPEQQAKVFRPPPAGSRLCVVATNVAETSLTIPGIKYVVDCGRVKKRFYDRVTGVSSFKVTWIS 654

  Fly   471 KANCRQRAGRVGRLRSGRVYRMVNKHFYQREMPEFGIPEMLRLPLQNSVLKAKVLNMGSPVEILA 535
            :|:..|||||.||...|..||:.:...: .:...|...|:.|.|:::.||:.|.||:...|..
Zfish   655 QASANQRAGRAGRTEPGHCYRLYSSAVF-GDFSLFSEAEITRRPVEDLVLQMKDLNIEKVVNF-- 716

  Fly   536 LALSPPNLSDIHNTILLLKEVGALYLTVDGIYDP-------------LDGDLTYWGTIMSRLPLD 587
            ...:||:...:.....||..:|||       ..|             |...::..|..|:..|:.
Zfish   717 PFPTPPSSEALIAAEELLISLGAL-------EKPARHGRLSEMEKARLSCPISPLGRAMAAFPVA 774

  Fly   588 TRQSRLIILGYIFNMLEEAIIIAAGLSTPGLFAHEGGRSQLGDSFWMHYIFSD-----GSGSDLV 647
            .|.::::.||.....::..|.|.:.::                   :..||.|     ||..:
Zfish   775 PRYAKMLALGRQQGCMQYIITIVSAMT-------------------VREIFEDYDRPAGSEEE-- 818

  Fly   648 AIWRVYLTYLNIVENGHDQESAIRWAKRFHVSLRSL---KEIHLLVQELRV------RCTHLGLI 703
                      |:..:|....|         |.:|.|   :...||:.:|.|      .|...||.
Zfish   819 ----------NVKMSGKKARS---------VQMRRLWAGQGASLLLGDLMVLLGAVGACEFAGLT 864

  Fly   704 PFPVNPNQMMDDREKAIMLKVIIAGAFYPNYFTRSKES-CADTDRNIYQTISGHDPCRTVYFTNF 767
            |      |..:  |..:..|.::.........|.:..: |||.|..:...::.....:.:.....
Zfish   865 P------QFCE--ENGLRFKAMLEIRRLRGQLTNAVNAVCADADVYVDNKMAPPTEAQVLCLRQI 921

  Fly   768 KPAYMGELYTRRIKE----------------LFQEVRIPPENM-------DVTFQE--GSQKVF- 806
            ..|.:|:...||::.                |...|.|.|.:.       .|.:||  .:.|::
Zfish   922 VLAGLGDHIARRVQAEELLDPKWRNAYKTPLLDDPVFIHPSSALHKTLPEFVVYQEIMETTKMYM 986

  Fly   807 --VTFKQDDWI---------------EGSSKYVPVSGRV---QSEVYKAVMMRQNRVER--PIHI 849
              |...|||||               ..:.::.|:.|||   |...:..|..:...:|.  |..:
Zfish   987 RGVCAVQDDWIPKLLPQYCHFSAPEESPAPRFCPLIGRVKCHQQSTFFRVSWKLPAIEMDYPEGL 1051

  Fly   850 MNPSAFMSYVQQRGIGDVIEGRWIPPTKPLNVELLALPSVFDKT 893
            .....|..:        .:||:..|..:..:..||:.||...||
Zfish  1052 ERYKLFAKF--------FLEGQVCPKIQKFSSCLLSSPSTMLKT 1087

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spn-E	NP_476741.1	HrpA	113..>697	CDD:224557	173/703 (25%)
spn-E	NP_476741.1	TUDOR	892..1016	CDD:395449	2/2 (100%)
dhx37	XP_005172500.1	HrpA	200..1007	CDD:224557	205/882 (23%)
		DEXDc	272..412	CDD:238005	54/142 (38%)
		HELICc	583..667	CDD:197757	35/83 (42%)
		HA2	730..781	CDD:282288	11/57 (19%)
		HA2	761..>813	CDD:214852	11/70 (16%)
		OB_NTP_bind	<918..1004	CDD:285018	18/85 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900