DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spn-E and dhx32a

DIOPT Version :9

Sequence 1:	NP_476741.1	Gene:	spn-E / 41919	FlyBaseID:	FBgn0003483	Length:	1434	Species:	Drosophila melanogaster
Sequence 2:	NP_001189401.3	Gene:	dhx32a / 100006246	ZFINID:	ZDB-GENE-130613-6	Length:	728	Species:	Danio rerio

Alignment Length:	814	Identity:	176/814 - (21%)
Similarity:	304/814 - (37%)	Gaps:	213/814 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 NGTLLNEQPQGKRIRTLDDLDTDDE-----GEETEIRRDD--EYYKKFRFNLNRDKNLSIYAKRE 122
            ||.|..|  .||.       :.|.|     |::.|:.:.|  .|..::...|...|.|.::..|.
Zfish     4 NGELSGE--LGKE-------EEDSENLFEFGDDLELNQFDGLPYSSRYYRLLQERKTLPVWKYRH 59

  Fly   123 EILAAINAHPVVIIKGETGCGKTTQVPQ----YILDEAYKSGKYCNIVVTQPRRIAAISIANRVC 183
            |.:..:..:.::|:.|.|..||:||:||    :.|...|:.|.   :|.:|.:|..|:.:|.||.
Zfish    60 EFMTLLENNQILIVSGTTKTGKSTQIPQWCAEFCLSAQYQHGV---VVCSQIQRRQAVDLALRVA 121

  Fly   184 QEREWQQNTVCSFQVGLHRPNSLEDTRLLYCTTGVLLNNLINNKTLTHYTHIVLDEVHERDQNMD 248
            .|.:........:.:.|....| .||.|.|||..:||..::::..|..|..:::|:.|||..:.|
Zfish   122 DEMDVNIGHEIGYSIPLETCCS-NDTILRYCTDDILLREMMSDPLLEQYGVVLVDQAHERTVSTD 185

  Fly   249 FLLIVVRRLLATNSRHVKIILMSATIDAKELSDYFTTTNSIPPVITTNHRRKHSIEKFYRDQLGS 313
            .||.::|.:|.... .::::::||....:.|..::   .|:|.:
Zfish   186 VLLGLLREVLLQRP-ELRLVVLSAPPTPETLLTHY---GSVPRL--------------------- 225

  Fly   314 IIWNEEDVGHQQVPEINKHGYRAAVKIIVIIDNMERKAAIQSRQSYDEALRY----------GAV 368
                     |.:.|        :|.::|        .::..|.:|:..|||.          |.|
Zfish   226 ---------HLEAP--------SAGEVI--------HSSSSSSESFYSALRLALEVHRSREPGDV 265

  Fly   369 LIFLPGIYEIDTMAENLTCMLENDPNIKVSIVRCFSLMTPENQRDVFNP---PPPGFRKIILTTN 430
            .:||....|:......:|   :....:.||:....::........:..|   .|...|:|.::.:
Zfish   266 AVFLATEQEVVCACNIIT---KEASRMSVSLGELLAVPMCSGHAGICPPVTESPQMSRRIFVSCS 327

  Fly   431 IAESSI-TVPDVSYVIDFCLAKVKVTDTASSFSSLRLTWASKANCRQRAGRVGRLRSGRVYRMVN 494
            ..|... :|..:::|||..:.|             ||.:    |.|.||       |..|.|.::
Zfish   328 QLEDLFWSVDSIAFVIDTGVEK-------------RLVY----NPRLRA-------SSEVIRPIS 368

  Fly   495 KHFYQREMPEFGIPEMLRLPLQNSVLKAKVL---NMGSPVEILALALSPPNLSDIHNTILLLKEV 556
            |  .|.||         |..|..|..|...|   ::..|.||....|.    |:|.:|.|.||.:
Zfish   369 K--CQAEM---------RKQLTGSTGKCFCLYPEDVQLPAEIHPRILE----SNITSTALFLKRM 418

  Fly   557 GALYLT---------VDGIYDPL-----------DGDLTYWGTIMSRLPLDTRQSRLIILGYIFN 601
            .|..:|         .:|:...|           ||:|:..|.|||.|||:.:.::.::....|:
Zfish   419 EAAGVTHCHFINRPDPEGLMQALEELDYLAALDNDGNLSEMGIIMSELPLEPQMAKALLASCEFD 483

  Fly   602 MLEEAIIIAAGLSTPGLFAHEGGRSQLGDSFWMHYIFSDGSGSDLVAIWRVYLTYLNIVENGH-D 665
            ...|.:.|||.|:.|..|. |.....|.:....|..|....|.....| .:|.|:.......: .
Zfish   484 CASEMLTIAAMLTAPSCFI-EPPVGMLTEVMRCHMKFQHPEGDHFTLI-NIYNTFKRSQREPYFS 546

  Fly   666 QESAIRWAKRFHVSLRSLKEIHLLVQELRVRCTHLGLIPFPVNPNQMMDDREKAIMLK-VIIAGA 729
            ||   :|.:::::...:|:....:..:|   ...|..|..|:: ......:..|:.:| .::||.
Zfish   547 QE---QWCEQYYLCCAALQTADAIRSQL---SDVLKRIELPIS-EPAFGTKTNALNIKRALLAGY 604

  Fly   730 FYP---------NYFTRSKESCADTDR--------------------------NIYQTISGHDPC 759
            |..         |||....:..|...|                          |..:|::...|.
Zfish   605 FMQMARDVDGSGNYFMLLNKHVAQAHRLSAYGAKAQKLGLPEWLLFHEYSLTDNSIRTLTHISPH 669

  Fly   760 RTV------YFTNFKPAYMGELYTRRIKELFQEV 787
            ..|      :|.|..|:        ..||:.|.:
Zfish   670 AFVQMAPQYFFCNLPPS--------ESKEILQNI 695

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spn-E	NP_476741.1	HrpA	113..>697	CDD:224557	140/625 (22%)
spn-E	NP_476741.1	TUDOR	892..1016	CDD:395449
dhx32a	NP_001189401.3	HrpA	14..>610	CDD:224557	155/707 (22%)
dhx32a	NP_001189401.3	OB_NTP_bind	569..678	CDD:311586	18/112 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900