DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4576 and oac-55

DIOPT Version :9

Sequence 1:	NP_650495.1	Gene:	CG4576 / 41914	FlyBaseID:	FBgn0038366	Length:	676	Species:	Drosophila melanogaster
Sequence 2:	NP_001317839.1	Gene:	oac-55 / 178792	WormBaseID:	WBGene00021479	Length:	742	Species:	Caenorhabditis elegans

Alignment Length:	700	Identity:	158/700 - (22%)
Similarity:	265/700 - (37%)	Gaps:	176/700 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 IAEISQYDRHH---------FDHRQLYFGLCLRECEASL-AGLNKSELEALQAGLLSENAKVNVY 130
            :.:.::|.|||         .|..:..:.:.:.:....| :|:.:..:  |..|..||...:.::
Worm    86 VIDAARYARHHSTAAVPASMTDQERKDYLIPMMDAAGKLGSGIVRGHI--LSTGAFSECKSIQMF 148

  Fly   131 L---------DLFS--------MEANNRQRHQRL----TNACLNWRLQ--------RRGFGVLAK 166
            .         |.:|        |..|:......|    .:.||.|..:        |...|. :|
Worm   149 SSSLNRTVQGDYYSSRILFDMKMRPNSFNSSCNLPQIGVDLCLPWSCRNEDLTGYFREALGP-SK 212

  Fly   167 SVVEYC-----DEAGHQVEDDAWNLTFYGILGTLLVLACLGSLVDLHLKRSRHDKMLKERDHYKT 226
            ::...|     ::....:....|.:..  ||..::.|..|....|:..|...:||..||
Worm   213 ALSPVCSVRNVNQRVPVISLGTWIVLL--ILSLIVGLCILSGFSDIFQKFQLNDKTRKE------ 269

  Fly   227 PPKSTAQQVLLTFSVARNWYRL-NQEPSGKIGRELRFLDCFKFFAMFMVIFAHTNWVIYESAISN 290
              :....::...||..||...: |.:...|.| ::..|:|.:..:.|.|||.|.:.:.: ..|:|
Worm   270 --EGFGWKLFSAFSFHRNLKEIFNTKNCHKEG-QVTSLNCIRVISTFWVIFGHCSEITF-MVITN 330

  Fly   291 PQDPERLLH-----TAAGTLLVSGSLITVTFFVISGLLLTINWLAVSRSLESKKDTWSFGQYALL 350
            |.|    |:     |..|||:.:......|||.||..||:..|.   :.||.:   |:    |||
Worm   331 PID----LYDFTKDTYTGTLISNAYFSVDTFFFISAFLLSFLWF---KQLEKQ---WN----ALL 381

  Fly   351 ----FVKFNIFRYIRLTVPYAFVLLMSGVYFENAGGPLWRHIFEREQL-------------ACRR 398
                ::.|.:.|..||:..|...:|            .:..:|.|..:             .|:.
Worm   382 SPGGWLMFYVHRIARLSPVYYVTIL------------FFTFVFTRSMVDMPAFMTPAVVDDTCQN 434

  Fly   399 NWWTNLLYVNNFVRTDERCLLQGWYLAADTHSFVLS-LVLLMLGHRFVRWSKQLYAGILGLFV-V 461
            ::|.||||:.|.|...:.|....||||.|...:::| |:||..|         |...::||.: .
Worm   435 SYWVNLLYIQNIVGPKDICYFISWYLATDLQIYIMSPLILLSFG---------LGGAVVGLLIST 490

  Fly   462 VPMVLTYAMNYYPIFVPTPQTQKDSFIGDRQFTEFYTSSFMNFG----------------SYFCG 510
            ...:.:.|.|.|.:.                |..|..|.: |:|                :|...
Worm   491 AAFLASTAFNAYQMI----------------FWHFPPSDY-NYGPKDPLYDPSKRRYAAWNYHNP 538

  Fly   511 VLAALVYDQLALKQYKLRELKSFQL-LWFTLIPVGILWLFSAHP------IFQHYYVTPSAIWG- 567
            ::...:|....:..|.:|.:....: .|..    .|:|..|...      |.:.|  |...:|.
Worm   539 LIRCQIYIMGMVLGYFMRRIPKININPWVD----RIMWCLSLGSMIFVIVIMEDY--TSGHLWSP 597

  Fly   568 ---ALYAGLQRNIWGFGLGIFIVGMASKVGWIFRKFCCLPIFRILGRLTYGAFIVHLLVARIVLA 629
               |||:...|.:||..|...::....:.| :..||..||::..|.||::.|::|||:||.....
Worm   598 LQTALYSCFSRVVWGLALSWIVISTYYRKG-LINKFMSLPVWTPLARLSFCAYLVHLMVAAYFFG 661

  Fly   630 TVREPIYFGTGMMFAFIFFTVTVSYLCSFLLAIF----LELPVSSFLKLM 675
            .....:||.|...|..:.....:|  ||||:|||    .|||.:....|:
Worm   662 RNHSELYFSTLPYFVLVIAIPVIS--CSFLVAIFWSTMFELPFAKVEALL 709

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4576	NP_650495.1	Acyl_transf_3	260..657	CDD:280013	106/447 (24%)
CG4576	NP_650495.1	OafA	303..668	CDD:224748	102/414 (25%)
oac-55	NP_001317839.1	NRF	111..220	CDD:214781	18/111 (16%)
oac-55	NP_001317839.1	OafA	299..690	CDD:224748	110/453 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160161175
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3700
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740