DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4576 and oac-31

DIOPT Version :9

Sequence 1:	NP_650495.1	Gene:	CG4576 / 41914	FlyBaseID:	FBgn0038366	Length:	676	Species:	Drosophila melanogaster
Sequence 2:	NP_503441.2	Gene:	oac-31 / 178643	WormBaseID:	WBGene00018707	Length:	705	Species:	Caenorhabditis elegans

Alignment Length:	732	Identity:	171/732 - (23%)
Similarity:	286/732 - (39%)	Gaps:	129/732 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 MTMMMLHIVILAATFTAAQCFQL---NMTQFYEMPPLYDLDDYDRCLQ---------ELNGQAST 56
            ||.::..::.|...|  :.|...   |....::..||:||.  ::||.         |:....|.
Worm     1 MTRLLFLVLSLFLPF--SHCISTMNSNWKDIFDPKPLHDLS--EKCLNDTDTWLKSLEIFSTVSV 61

  Fly    57 YCFVRAEVQPDESVAAWRAIAEISQYDRHH-------FDHRQLYFGLCLRECEASLAGLNKSELE 114
            .|.........||......:..:.|.|...       .:.|.||.| ..:||:.    ::....:
Worm    62 ECLTLNNCTTQESKILDENLYAVKQLDAFGEFPTPGLLELRTLYDG-SYQECDR----IDGERYK 121

  Fly   115 ALQAGLLSENAKVNVYLDLFSMEANNRQR----------HQRLTNACLNWRLQRRGFGVLAKSVV 169
            .....|:....| |:.....|:.:|...|          ||.:.|.          |..|:....
Worm   122 TNYCYLILNFGK-NISCSAPSVYSNVTLRMAVCLPDSCSHQDMINI----------FNQLSPYPF 175

  Fly   170 EYCDE--AGHQVEDDA--WNLTFYGILGTLLVLACLGSLVD------LHLKRSRHDKMLKERDHY 224
            ..||.  ..:.||.|.  |..|.:  |..::.:|...:|:|      |.|..      |||
Worm   176 TACDAYCVKNTVEKDVPFWGFTVF--LTIVIAVAIFATLLDYVQDAVLGLSN------LKE---- 228

  Fly   225 KTPPKSTAQQVLLTFSVARNWYRLNQEPSGKIGRELRFLDCFKFFAMFMVIFAHTNWVIYESAIS 289
                |:...:::||||:..|...:......|.| .::.|||.:..::|.||..|:  .||.:...
Worm   229 ----KNIFIKIILTFSLWTNAELILSVKEHKPG-FIKSLDCIRGLSIFWVITGHS--FIYMTQAD 286

  Fly   290 NPQDPERLLHTAAGTLLVSGSLITVTFFVISGLLLTINWLAVSRSLE--SKKDTWSFGQYALLFV 352
            ..:......:.....|:::..:...:||.:||:::...:..:..:::  :...||         :
Worm   287 TMKPVMEFQNQFWNHLIINAPVSVDSFFALSGIVVAYLFFKMKPNIKMAASPVTW---------I 342

  Fly   353 KFNIFRYIRLTVPYAFVLLMSGVYFENAGGPLWRHIFEREQL----ACRRNWWTNLLYVNNFVRT 413
            .|.:.||:|||......:....|||....|| :...|...|.    ||:..||.||||:|||..:
Worm   343 LFYVHRYLRLTPTVMIFIGFFTVYFPYVQGP-FAASFSNVQFPQVEACKDYWWHNLLYINNFDNS 406

  Fly   414 DER----CLLQGWYLAADTHSFVLS-LVLLMLGHRFVRWSKQLYAGILGLFVVVPMVLTYAMNYY 473
            ..|    |....||||.||..::|: :||:.|...|...:..:.||.:|     .::.||.:  :
Worm   407 QHRERNTCYAITWYLAVDTQLYILAPIVLIALFFSFAVGTAIIVAGCVG-----SIIATYIL--F 464

  Fly   474 PIF-VPTPQTQKDSFIGDRQ--FTEFYTSSFMNFGSYFCGVLAALVYDQLALKQYKLRELKSFQL 535
            .:: ||......    ||.:  |...|:..::....|..|:|...:     |..|..|.::   |
Worm   465 DLYDVPADPLGN----GDHRYFFGIGYSKPWIRCPPYLVGLLTGYL-----LATYGTRRIR---L 517

  Fly   536 LWFTLIPVGIL-WLFSAHPIFQHYYVTPSAIWGALYAGLQRNIWGFGLGIF---IVGMASKVGW- 595
            .|...|.|.|: ::.:...||..|.......|.........|....|.|:|   :|| |:.:||
Worm   518 NWAVSIGVWIVAFVVAGFCIFSTYDYDKGEQWSTFSRATFFNFHRLGWGVFVCWVVG-ANHMGWG 581

  Fly   596 -IFRKFCCLPIFRILGRLTYGAFIVHLLVARIVLATVREPIYFGTGMMFAFIFFTVTV-SYLCSF 658
             ....|...||::..|||:|.|:|||.:|....|.......|.....:|.:|....|| |::.:|
Worm   582 GPIDTFMSHPIWQPFGRLSYCAYIVHWMVLYFYLNVGGALHYTSAWHVFLYISIPATVLSFVFAF 646

  Fly   659 LLAIFLELPVSSFLKLM 675
            ..:...|:|:....|::
Worm   647 FWSCLFEMPILKLEKML 663

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4576	NP_650495.1	Acyl_transf_3	260..657	CDD:280013	107/417 (26%)
CG4576	NP_650495.1	OafA	303..668	CDD:224748	100/385 (26%)
oac-31	NP_503441.2	NRF	80..184	CDD:214781	21/119 (18%)
oac-31	NP_503441.2	OafA	253..659	CDD:224748	112/438 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160161188
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3700
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740