DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4576 and nrf-6

DIOPT Version :9

Sequence 1:	NP_650495.1	Gene:	CG4576 / 41914	FlyBaseID:	FBgn0038366	Length:	676	Species:	Drosophila melanogaster
Sequence 2:	NP_495680.1	Gene:	nrf-6 / 174287	WormBaseID:	WBGene00003813	Length:	822	Species:	Caenorhabditis elegans

Alignment Length:	664	Identity:	147/664 - (22%)
Similarity:	273/664 - (41%)	Gaps:	125/664 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 WR---AIAEISQYDRHHFDHRQLYFGLCL-----REC------EASLAGLNKSELEALQAGLLSE 123
            |:   .:|.|..|:|   |:..:|||..:     :.|      ..:..|...:....|:.|:...
Worm   196 WKGQYCLATIDAYER---DNPLVYFGNMMSGPPDKHCYDKTVKNVTDDGFCFALFPVLKFGVCMP 257

  Fly   124 NAKVNVYLDLFSMEANNRQRHQRLTNACLNWRLQRRGFGVLAKSVVEYCDEAGHQVEDDAWN--- 185
            |...|               |.  ....|::.::.....|..|||.....|...:...||.:
Worm   258 NTCTN---------------HD--VKQMLSFAIRATEGAVGTKSVCNVDVECRAESYSDAMSENG 305

  Fly   186 ---LTFYGILGTLLVLACLGSLVDLHL--KRSRHDKMLKERDHYKTPPKSTAQQVLLTFSVARNW 245
               ...|.::.| :||...|:|.||.:  |..:.:|.....:|       ...:.:|.||:..|.
Worm   306 LAMFALYLLIAT-VVLVTFGTLYDLFIVSKAPQDEKNSSAFNH-------PFIKFILAFSMYTNG 362

  Fly   246 YRLNQEPSGKIGRELRFLDCFKFFAMFMVIFAHTNWVIYESAISNPQDP-----ERLLHTAAGTL 305
            ..:.|  |.|..||:..|...:|.:|..:|..||.:.|..|..::...|     .:..||   .:
Worm   363 SEILQ--SKKNDREINSLHGVRFLSMCWIILGHTYYYIGTSLTTDNLVPTLINFPKQFHT---QI 422

  Fly   306 LVSGSLITVTFFVISGLLLTINWLAVSRSLE----SKKDTWSFGQYALLFVKFNIFRYIRLTVPY 366
            :|...|...:||.:||:|...::...:...:    .|...:::..:.:.:.|    ||||:|..|
Worm   423 IVQAPLAVDSFFFLSGMLAAFSFFKKTMKADPNHPPKLSAFNWQTWPMYYYK----RYIRITPTY 483

  Fly   367 AFVLLMSGVYFEN-AGGPLWRHIFEREQLACRRNWWTNLLYVNNFVRTDERCLL-QGWYLAADT- 428
            ..|:|.....|.. :.||.||.|   |:..|...|||||:|:|||:..|:.|.: ..||||.|.
Worm   484 IIVMLFDVTLFTYISNGPFWRPI---ERQGCSIAWWTNLIYLNNFLLQDQECCMGWTWYLANDMQ 545

  Fly   429 -HSFVLSLVLLMLGHRFVRWSKQ----LYAGILGLFVVVPMVLTYAMNYYPIFVPTPQTQKDSFI 488
             |.|::.|::::    |::|..:    |..|::.|..::.:::|....|.|..:.|.:.|....:
Worm   546 FHIFLMPLLVIV----FLKWGMKVGLGLSTGLIALSSLIRLIITQIYGYPPAPILTAKLQIVYQL 606

  Fly   489 GDRQFTEFYTSSFMNFGSYFCGVLAALVYDQLALKQYKLRELK----SFQLLWFTLIPVGILWLF 549
            .| .:.:.|...::....:..|::.|.:.:....::.|..::|    :..:.|.|...:|:
Worm   607 ND-YWNDVYVRPYIRCTPFIVGIVVAYLLNAWTTREQKDLKIKLERRTVIICWCTSTVLGL---- 666

  Fly   550 SAHPIFQHYYVTP----SAIWGALYAGLQRNIWGFGLGIFIVGMASKVGWIFRKFCCLP------ 604
              :.:|..|:...    |..|..||     .|:|      ....|..:||:.  |.|..
Worm   667 --YSVFGLYWFAKTGDISKPWEILY-----TIFG------TPAYALALGWVV--FACTTGNGGPV 716

  Fly   605 -------IFRILGRLTYGAFIVHLLVARIVLATVREPIYFGTGM-MFAFIFFTVTVSYLCSFLLA 661
                   :|..|.::|:.|:::|.::.:|...:..:|.:|.|.: |..:....|..||..:|..:
Worm   717 DTILSWRLFVPLSKITFCAYLLHPIMLQIYNLSRPQPFHFTTFIQMIRYTVEAVFASYTIAFFFS 781

  Fly   662 IFLELPVSSFLKLM 675
            :..|.|::...:::
Worm   782 LAFEKPLNKIDEML 795

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4576	NP_650495.1	Acyl_transf_3	260..657	CDD:280013	100/435 (23%)
CG4576	NP_650495.1	OafA	303..668	CDD:224748	91/398 (23%)
nrf-6	NP_495680.1	NRF	151..288	CDD:214781	21/111 (19%)
		OafA	375..790	CDD:224748	103/448 (23%)
		Acyl_transf_3	375..777	CDD:280013	100/435 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3700
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810