DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Man-IIb and GMII

DIOPT Version :9

Sequence 1:	NP_001262614.1	Gene:	alpha-Man-IIb / 41913	FlyBaseID:	FBgn0026616	Length:	1249	Species:	Drosophila melanogaster
Sequence 2:	NP_196999.1	Gene:	GMII / 831347	AraportID:	AT5G14950	Length:	1173	Species:	Arabidopsis thaliana

Alignment Length:	1230	Identity:	377/1230 - (30%)
Similarity:	579/1230 - (47%)	Gaps:	219/1230 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 TKSAQTSVSPEEQSEEQYTN-SNWGDKCYELIQSNTNITASEEHSKFDF-----QPEWMRSKEYW 148
            |..:...|.|.:....:..| ||.|        :..:||..:.:.:.:|     .|        |
plant    87 TSRSNRIVKPRKNINRRPLNDSNSG--------AVVDITTKDLYDRIEFLDTDGGP--------W 135

  Fly   149 DRGFEERFDAQKKDKQRPPLKIIVVPHSHNDPGWLKTFTNYFQSDSRQILNLLVTKMQEYTDMTF 213
            .:|:...:...:.:|::  |||.|||||||||||..|...|:|..||.||:.:|..:.:.:...|
plant   136 KQGWRVTYKDDEWEKEK--LKIFVVPHSHNDPGWKLTVEEYYQRQSRHILDTIVETLSKDSRRKF 198

  Fly   214 IWSEISFLQLWWDQAHPTKQRALKRLIDAGRIEITTGGWVMTDEANVHIYPMLDQLIEGHQWLKN 278
            ||.|:|:|:.||..|.|.||.||.:|:..|::||..|||||.||||.|.:.:::|:.||:.||.:
plant   199 IWEEMSYLERWWRDASPNKQEALTKLVKDGQLEIVGGGWVMNDEANSHYFAIIEQIAEGNMWLND 263

  Fly   279 NLNVTPKVGWSIDPFGHGSTVPYLLSGANFEGTIIQRIHYAWKQWFARQQSGDFIWKPYWRSRKD 343
            .:.|.||..|:|||||:.||:.|||....||..:|||.||..|:..|:.::.::||:..|.:.:.
plant   264 TIGVIPKNSWAIDPFGYSSTMAYLLRRMGFENMLIQRTHYELKKDLAQHKNLEYIWRQSWDAMET 328

  Fly   344 KDSEAGSLLTHNMPFDIYSIKGSCGPHPFICLNFDFRKIPG---EYTEYSVKAQFITDDNLESKA 405
            .|     :..|.|||..|.|..:|||.|.||..|||.::.|   |...:.......|.:|::.:|
plant   329 TD-----IFVHMMPFYSYDIPHTCGPEPAICCQFDFARMRGFKYELCPWGKHPVETTLENVQERA 388

  Fly   406 QLLLEQYARTASLFPHNVALIPVGDDFRYNKDREVDQQYQNYKKLIDHIMANRRLYNADIRFGTP 470
            ..||:||.:.::|:..|..|||:||||||....|.:.|::||:.|.|||.:|..| ||:.:|||.
plant   389 LKLLDQYRKKSTLYRTNTLLIPLGDDFRYISIDEAEAQFRNYQMLFDHINSNPSL-NAEAKFGTL 452

  Fly   471 SDYFEAIKE---RMKDHTP---------GFPTFKGDFFVYSDIFSEGRPAYWSGYFTTRPFYKLL 523
            .|||..::|   |:....|         |||:..||||.|:|    .:..|||||:.:|||:|.:
plant   453 EDYFRTVREEADRVNYSRPGEVGSGQVVGFPSLSGDFFTYAD----RQQDYWSGYYVSRPFFKAV 513

  Fly   524 SSELEHQLRSAEIV--FTLAYNTARQAKRENAIKIYEKNYELIINARRNLGLFQHHDAITGTSKA 586
            ...|||.||.|||:  |.|.|....|.::......|:     :..|||||.||||||.:|||:|.
plant   514 DRVLEHTLRGAEIMMSFLLGYCHRIQCEKFPTSFTYK-----LTAARRNLALFQHHDGVTGTAKD 573

  Fly   587 AVMRDYAMRLFESTQNMVKMQESCLELLL-----QKGQPRHHGFLLSEFERDNFNKLPRKMPIQM 646
            .|::||..|:..|.|::.......:|:||     ::...:...|..:|..|..::..|...||..
plant   574 YVVQDYGTRMHTSLQDLQIFMSKAIEVLLGIRHEKEKSDQSPSFFEAEQMRSKYDARPVHKPIAA 638

  Fly   647 ANGDESTPTVPAGEGGAGGSSSSGSVGSFVLYNSLAQKRLEVVTLRVQHPNVKIVNDKGVELNHI 711
            ..|:..|                     .:|:|...|.|.||||:.|....:.:: |........
plant   639 REGNSHT---------------------VILFNPSEQTREEVVTVVVNRAEISVL-DSNWTCVPS 681

  Fly   712 QINPVWNITDTYEQGLGTSVSGTVGRIRTSTRQFEVMFVAELEPLSLSTYRVQVDEVNFKRNIAT 776
            ||:|.....||                :..|.:..:.:.|.:..|.|.||.:....|
plant   682 QISPEVQHDDT----------------KLFTGRHRLYWKASIPALGLRTYFIANGNV-------- 722

  Fly   777 IYCDDCTESQPASVSPPEEIESSPTSVFEARGKPAGDI-QLENPHMRLLFDEKSGFLKTITRKNQ 840
                :|.::.|:.:....|.:..|.....:..|...|: ::.|.|..|:||.|:|.|:.|..:|.
plant   723 ----ECEKATPSKLKYASEFDPFPCPPPYSCSKLDNDVTEIRNEHQTLVFDVKNGSLRKIVHRNG 783

  Fly   841 KKELLKPLQCNIKFAAYRSAQFHSGAYLFKTDPEQSEAEKEVLEGYTDMRIIITSGPIASDV--- 902
            .:.::     ..:...|.|.:  |||||||.|   .||:..|   ..|..::.:.|.:..:|
plant   784 SETVV-----GEEIGMYSSPE--SGAYLFKPD---GEAQPIV---QPDGHVVTSEGLLVQEVFSY 835

  Fly   903 --TVIYGPFLAHTVRIF-NTRTHLDAAIYVE-------NDIDFEPPPKNRETELFMRFVTNIDNI 957
              |......|:...|:: ...|..|..:.:|       ||.|        :.||.:|:.|::||
plant   836 PKTKWEKSPLSQKTRLYTGGNTLQDQVVEIEYHVELLGNDFD--------DRELIVRYKTDVDN- 891

  Fly   958 AQAPMQRDPLKEPVDAATMPELPVFYSDQNGFQYHERIKVPAIGIEGNYFPITSGAFIQDSR-LR 1021
                                 ..|||||.||||...|.....|.::|||:|:.|.||||.|. .|
plant   892 ---------------------KKVFYSDLNGFQMSRRETYDKIPLQGNYYPMPSLAFIQGSNGQR 935

  Fly  1022 LTLLTTHAQGAASYEPGQLEVMLDRRTLYDDYRGMGEGVVDSRLTRHKFWLLVEDL-----PGGQ 1081
            .::.:..:.|.||.:.|.||:|||||.:.||.||:|:||:|:|.....|.||.|..     |...
plant   936 FSVHSRQSLGVASLKEGWLEIMLDRRLVRDDGRGLGQGVMDNRAMTVVFHLLAESNISQADPASN 1000

  Fly  1082 HVTQPPSYKVLSQQAQQLANA-LRYPPNLYFVS-----NLEQPELAAALLPLVRLLPKGPLPCDV 1140
              |.|.:..:||    .|..| |.||.|.:...     ::..|:. .:..||.:     |||||:
plant  1001 --TNPRNPSLLS----HLIGAHLNYPINTFIAKKPQDISVRVPQY-GSFAPLAK-----PLPCDL 1053

  Fly  1141 HLTTLRTLSDPELQLFPSASA----------LLVLHRQGFDCS-VSAGRELSMEAIC--PLS--- 1189
            |:...:.   |.    ||..:          .|:|:|:.:|.: ...||:::..::.  |::
plant  1054 HIVNFKV---PR----PSKYSQQLEEDKPRFALILNRRAWDSAYCHKGRQVNCTSMANEPVNFSD 1111

  Fly  1190 -SKGLGNVQLGRLSLHTI-EATSLTG-TEQKSSRESYHIRSLAEISLEPMELRTFNLTFR 1246
             .|.|...::...||:.: |...:.| .:|:..|:|...|. ..:|:.|||:|.:.|..|
plant  1112 MFKDLAASKVKPTSLNLLQEDMEILGYDDQELPRDSSQPRE-GRVSISPMEIRAYKLELR 1170

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Man-IIb	NP_001262614.1	PLN02701	148..1246	CDD:178304	365/1164 (31%)
		GH38N_AMII_GMII_SfManIII_like	167..514	CDD:212120	151/361 (42%)
		Alpha-mann_mid	508..596	CDD:286360	40/89 (45%)
		Glyco_hydro_38C	813..1241	CDD:285047	133/472 (28%)
GMII	NP_196999.1	PLN02701	114..1170	CDD:178304	369/1193 (31%)
		GH38N_AMII_GMII_SfManIII_like	152..504	CDD:212120	151/363 (42%)
		Alpha-mann_mid	499..583	CDD:214875	40/88 (45%)
		Glyco_hydro_38C	755..1165	CDD:285047	133/472 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1959
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55783
OrthoDB	1	1.010	-	-		D1101882at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102728
Panther	1	1.100	-	-	LDO	PTHR11607
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.790