Protein Alignment alpha-Man-IIb and MAN2B1

DIOPT Version :9

• Sequence 1: NP_001262614.1
• Gene: alpha-Man-IIb / 41913
• FlyBaseID: FBgn0026616
• Length: 1249
• Species: Drosophila melanogaster
• Sequence 2: XP_005259970.1
• Gene: MAN2B1 / 4125
• HGNCID: 6826
• Length: 1012
• Species: Homo sapiens
• Alignment Length: 1141
• Identity: 291/1141 - (25%)
• Similarity: 454/1141 - (39%)
• Gaps: 269/1141 - (23%)

  Fly   168 LKIIVVPHSHNDPGWLKTFTNYF--------QSDSRQILNLLVTKMQEYTDMTFIWSEISFLQLW 224
            |.:.::||:|:|.|||||...||        .:..:.||:.:::.:.......||:.||:|...|
Human    63 LNVHLLPHTHDDVGWLKTVDQYFYGIKNDIQHAGVQYILDSVISALLADPTRRFIYVEIAFFSRW 127

  Fly   225 WDQAHPTKQRALKRLIDAGRIEITTGGWVMTDEANVHIYPMLDQLIEGHQWLKNNL--NVTPKVG 287
            |.|.....|..::.|:..||:|...|||||.|||..|...::||:..|.::|::..  :..|:|.
Human   128 WHQQTNATQEVVRDLVRQGRLEFANGGWVMNDEAATHYGAIVDQMTLGLRFLEDTFGNDGRPRVA 192

  Fly   288 WSIDPFGHGSTVPYLLSGANFEGTIIQRIHYAWKQWFARQQSGDFIWKPYWRSRKDKDSEAGSLL 352
            |.||||||......|.:...|:|....|:.|..| |...|:   ...:..||:..........|.
Human   193 WHIDPFGHSREQASLFAQMGFDGFFFGRLDYQDK-WVRMQK---LEMEQVWRASTSLKPPTADLF 253

  Fly   353 THNMPFDIYSIKGSCGPHPFICLNFDFRKIPGEYTEYSVKAQFITDDNLE-SKAQLLLEQYARTA 416
            |..:|......:..|  ...:|::....:.| ...||:.|.  :.|..|. :.||   .:|.||
Human   254 TGVLPNGYNPPRNLC--WDVLCVDQPLVEDP-RSPEYNAKE--LVDYFLNVATAQ---GRYYRT- 309

  Fly   417 SLFPHNVALIPVGDDFRYNKDREVDQQYQNYKKLIDHIMANRRLYNADIR--FGTPSDY-FEAIK 478
                 |..::.:|.||:|   ...:..::|..|||..:.|.::...:.:.  :.||:.| :|..|
Human   310 -----NHTVMTMGSDFQY---ENANMWFKNLDKLIRLVNAQQQAKGSSVHVLYSTPACYLWELNK 366

  Fly   479 ERMKDHTPGFPTFKGDFFVYSDIFSEGRPAYWSGYFTTRPF---YKLLSSELEHQLRSAEIVFTL 540
            ..:.     :.....|||.|:|    |...:|:|||::||.   |:.||..........|.:..|
Human   367 ANLT-----WSVKHDDFFPYAD----GPHQFWTGYFSSRPALKRYERLSYNFLQVCNQLEALVGL 422

  Fly   541 AYNTARQAKRENAIKIYEKNYELIINARRNLGLFQHHDAITGTSKAAVMRDYAMRLFESTQNMVK 605
            |.|.......::|            .....:.:.|||||::|||:..|..|||.:|...
Human   423 AANVGPYGSGDSA------------PLNEAMAVLQHHDAVSGTSRQHVANDYARQLAAG------ 469

  Fly   606 MQESCLELLLQKGQPRHHGFLLSEFERDNFNKLPRKMPIQMANGDESTPTVPAGEGGAGGSSSSG 670
             ...| |:||.....|..||      :|:|. ..:::.|.:.         |.        |.:.
Human   470 -WGPC-EVLLSNALARLRGF------KDHFT-FCQQLNISIC---------PL--------SQTA 508

  Fly   671 SVGSFVLYNSLAQKRLEVVTLRVQHPNVKIVNDKGVELNHIQINPVWNITDTYEQGLGTSVSGTV 735
            :....::||.|.:|...:|.|.|.. .|.:|.|..                      |.:|...|
Human   509 ARFQVIVYNPLGRKVNWMVRLPVSE-GVFVVKDPN----------------------GRTVPSDV 550

  Fly   736 GRIRTSTRQF---EVMFVAELEPLSLSTYRVQVDEVNFKRNIATIYCDDCTESQPASVSPPEEIE 797
            ....:|..|.   |::|.|.|..|..|||.|                        |.|...:...
Human   551 VIFPSSDSQAHPPELLFSASLPALGFSTYSV------------------------AQVPRWKPQA 591

  Fly   798 SSPTSVFEARGKPAGDIQLENPHMRLLFDEKSGFLKTITRKNQKKELLKPLQ-----CNIKFAAY 857
            .:|..:......||  :.:||.|:|..||..:|.|..|...||  :||.|::     .|......
Human   592 RAPQPIPRRSWSPA--LTIENEHIRATFDPDTGLLMEIMNMNQ--QLLLPVRQTFFWYNASIGDN 652

  Fly   858 RSAQFHSGAYLFKTDPEQSEAEKEV-LEGYTDMRIIITSGPIASDVTVIYGPFLAHTVRIFNTRT 921
            .|.| .||||:|:  |.|   :|.: :..:..:.::.|  |:..:|...:..:.:..||::..:.
Human   653 ESDQ-ASGAYIFR--PNQ---QKPLPVSRWAQIHLVKT--PLVQEVHQNFSAWCSQVVRLYPGQR 709

  Fly   922 HLDAAIYVENDIDFEPPPKNRETELFMRFVTNIDNIAQAPMQRDPLKEPVDAATMPELPVFYSDQ 986
            ||:    :|..:...|.......|:..||.|.::...:                      ||:|.
Human   710 HLE----LEWSVGPIPVGDTWGKEVISRFDTPLETKGR----------------------FYTDS 748

  Fly   987 NGFQYHERIK-----------VPAIGIEGNYFPITSGAFIQDSRLRLTLLTTHAQGAASYEPGQL 1040
            ||.:..||.:           .|   :.|||:|:.:..:|.|..::||:||..:||.:|...|.|
Human   749 NGREILERRRDYRPTWKLNQTEP---VAGNYYPVNTRIYITDGNMQLTVLTDRSQGGSSLRDGSL 810

  Fly  1041 EVMLDRRTLYDDYRGMGEGVVDSRLTRHKFWLLVEDLPGGQHVTQPPSYKVLSQQAQQLANALRY 1105
            |:|:.||.|.||.||:.|.::::   ....|:      .|:|:       ||...||..|...|.
Human   811 ELMVHRRLLKDDGRGVSEPLMEN---GSGAWV------RGRHL-------VLLDTAQAAAAGHRL 859

  Fly  1106 PPNLYFVSNLEQPELAAALLPLVRLLPKG-------------------PLPCDVHLTTLRTLSDP 1151
                     |.:.|:   |.|.|.|.|.|                   .||..|||.||.:.. |
Human   860 ---------LAEQEV---LAPQVVLAPGGGAAYNLGAPPRTQFSGLRRDLPPSVHLLTLASWG-P 911

  Fly  1152 ELQLFPSASALLVLHRQGFDCSVSAGRELSMEAICPLSSKGL-GNVQLGRLSLHTIEATSL---- 1211
            |:       .||.|..| |.....:||.||  |...|:.:.| ....:.||...|:.|..|
Human   912 EM-------VLLRLEHQ-FAVGEDSGRNLS--APVTLNLRDLFSTFTITRLQETTLVANQLREAA 966

  Fly  1212 ------TGTEQKSSRESYHIRSLAEISLEPMELRTF 1241
                  |.|.....:..|.: ..|.|:|||||:|||
Human   967 SRLKWTTNTGPTPHQTPYQL-DPANITLEPMEIRTF 1001

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Man-IIb	NP_001262614.1	PLN02701	148..1246	CDD:178304	291/1141 (26%)
		GH38N_AMII_GMII_SfManIII_like	167..514	CDD:212120	98/359 (27%)
		Alpha-mann_mid	508..596	CDD:286360	26/90 (29%)
		Glyco_hydro_38C	813..1241	CDD:285047	125/474 (26%)
MAN2B1	XP_005259970.1	PLN02701	63..1001	CDD:178304	289/1139 (25%)
		GH38N_AMII_LAM_like	63..341	CDD:212121	84/298 (28%)
		Alpha-mann_mid	388..466	CDD:214875	26/89 (29%)
		Glyco_hydro_38C	511..1001	CDD:285047	154/617 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1959
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810