DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Man-IIb and MAN2A1

DIOPT Version :9

Sequence 1:	NP_001262614.1	Gene:	alpha-Man-IIb / 41913	FlyBaseID:	FBgn0026616	Length:	1249	Species:	Drosophila melanogaster
Sequence 2:	NP_002363.2	Gene:	MAN2A1 / 4124	HGNCID:	6824	Length:	1144	Species:	Homo sapiens

Alignment Length:	1236	Identity:	393/1236 - (31%)
Similarity:	624/1236 - (50%)	Gaps:	192/1236 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 GSSSIIHQQKQQL--VIASNQKKSSETKSAQTSVSPEEQSEEQYTNSNWGD-------------- 114
            |..|::.::...|  ::|.|.:..|..:.:..::|...:...:.:.||:..
Human    46 GQLSMLQEKIDHLERLLAENNEIISNIRDSVINLSESVEDGPKSSQSNFSQGAGSHLLPSQLSLS 110

  Fly   115 ----KCYELIQS---NTNITASEEHSKFDF-QPEWMRSKEYWDRGFEERFDAQKKDKQRPPLKII 171
                .|....||   |:::...:.:|...| .|:    ...|.:||:..:::.:.|.:  ||::.
Human   111 VDTADCLFASQSGSHNSDVQMLDVYSLISFDNPD----GGVWKQGFDITYESNEWDTE--PLQVF 169

  Fly   172 VVPHSHNDPGWLKTFTNYFQSDSRQILNLLVTKMQEYTDMTFIWSEISFLQLWWDQAHPTKQRAL 236
            |||||||||||||||.:||:..::.|.|.:|.|::|.:...|||||||:|..|||.....|:.|:
Human   170 VVPHSHNDPGWLKTFNDYFRDKTQYIFNNMVLKLKEDSRRKFIWSEISYLSKWWDIIDIQKKDAV 234

  Fly   237 KRLIDAGRIEITTGGWVMTDEANVHIYPMLDQLIEGHQWLKNNLNVTPKVGWSIDPFGHGSTVPY 301
            |.||:.|::||.||||||.|||..|.:.::||||||||||:||:.|.|:.||:||||||..|:.|
Human   235 KSLIENGQLEIVTGGWVMPDEATPHYFALIDQLIEGHQWLENNIGVKPRSGWAIDPFGHSPTMAY 299

  Fly   302 LLSGANFEGTIIQRIHYAWKQWFARQQSGDFIWKPYWRSRKDKDSEAGS---LLTHNMPFDIYSI 363
            ||:.|.....:|||:|||.|:.||..::.:|.|:..|        :.||   :|.|.|||..|.|
Human   300 LLNRAGLSHMLIQRVHYAVKKHFALHKTLEFFWRQNW--------DLGSVTDILCHMMPFYSYDI 356

  Fly   364 KGSCGPHPFICLNFDFRKIPGEY--TEYSVKAQFITDDNLESKAQLLLEQYARTASLFPHNVALI 426
            ..:|||.|.||..|||:::||..  ..:.|..:.|...|::|:|::||:||.:.:.||...|.|.
Human   357 PHTCGPDPKICCQFDFKRLPGGRFGCPWGVPPETIHPGNVQSRARMLLDQYRKKSKLFRTKVLLA 421

  Fly   427 PVGDDFRYNKDREVDQQYQNYKKLIDHIMANRRLYNADIRFGTPSDYFEAI---KERMKDHTPG- 487
            |:||||||.:..|.|.|::||::|.|: |.::..:...|:|||.||:|:|:   .|..:|....
Human   422 PLGDDFRYCEYTEWDLQFKNYQQLFDY-MNSQSKFKVKIQFGTLSDFFDALDKADETQRDKGQSM 485

  Fly   488 FPTFKGDFFVYSDIFSEGRPAYWSGYFTTRPFYKLLSSELEHQLRSAEIVFTLAYNTARQAKREN 552
            ||...||||.|:|....    |||||||:|||||.:...:|..||:|||::   |...|||.:..
Human   486 FPVLSGDFFTYADRDDH----YWSGYFTSRPFYKRMDRIMESHLRAAEILY---YFALRQAHKYK 543

  Fly   553 AIKIYEKN-YELIINARRNLGLFQHHDAITGTSKAAVMRDYAMRLFESTQNMVKMQESCLELLLQ 616
            ..|....: |..:..|||||||||||||||||:|..|:.||..|||.|...:.|:..:...||:.
Human   544 INKFLSSSLYTALTEARRNLGLFQHHDAITGTAKDWVVVDYGTRLFHSLMVLEKIIGNSAFLLIL 608

  Fly   617 KGQPRHHG-----FLLSEFERDNFNKLPRKMPIQMANGDESTPTVPAGEGGAGGSSSSGSVGSFV 676
            |.:..:..     ||..:.::.:.:.||:|..|::                      |......|
Human   609 KDKLTYDSYSPDTFLEMDLKQKSQDSLPQKNIIRL----------------------SAEPRYLV 651

  Fly   677 LYNSLAQKRLEVVTLRVQHPNVKIVNDKGVELNHIQINPVWNITDTYEQGLGTSVSGTVGRIRTS 741
            :||.|.|.|:.:|::.|..|.|::.:..|..: .:|::.||:..:|        :|.|.
Human   652 VYNPLEQDRISLVSVYVSSPTVQVFSASGKPV-EVQVSAVWDTANT--------ISETA------ 701

  Fly   742 TRQFEVMFVAELEPLSLSTYRVQVDEVNFKRNIA--TIYCDDCTESQPASVSPPEEIESSPTSVF 804
               :|:.|.|.:.||.|..|:: ::..:...::|  .:|              ..::|.|.....
Human   702 ---YEISFRAHIPPLGLKVYKI-LESASSNSHLADYVLY--------------KNKVEDSGIFTI 748

  Fly   805 EARGKPAGDIQLENPHMRLLFDEKSGFLKTITRKNQKKELLKPLQCNIKFAAYRSA--QFHSGAY 867
            :........|.|||..:.|.||: :|.:|.:..|...|.    .:.|::|:.|.:.  :..||||
Human   749 KNMINTEEGITLENSFVLLRFDQ-TGLMKQMMTKEDGKH----HEVNVQFSWYGTTIKRDKSGAY 808

  Fly   868 LFKTDPEQSEAEKEVLEGYTDMRII-ITSGPIASDVTVIYGPFLAHTVRIFNTRTHLDAAIYVEN 931
            ||..|   ..|:..|   ||....: :|.|.|.|:||..: ..:.|.||:::.:.....::.|.|
Human   809 LFLPD---GNAKPYV---YTTPPFVRVTHGRIYSEVTCFF-DHVTHRVRLYHIQGIEGQSVEVSN 866

  Fly   932 DIDFEPPPKNRETELFMRFVTNIDNIAQAPMQRDPLKEPVDAATMPELPVFYSDQNGFQYHERIK 996
            .:|..   |....|:.|:..::|.:..:                      ||:|.||:|...|:.
Human   867 IVDIR---KVYNREIAMKISSDIKSQNR----------------------FYTDLNGYQIQPRMT 906

  Fly   997 VPAIGIEGNYFPITSGAFIQDSRLRLTLLTTHAQGAASYEPGQLEVMLDRRTLYDDYRGMGEGVV 1061
            :..:.::.|.:|:|:.|:|||::.|||||:..:.|.:|...||:||::|||.:.||.||:.:|:.
Human   907 LSKLPLQANVYPMTTMAYIQDAKHRLTLLSAQSLGVSSLNSGQIEVIMDRRLMQDDNRGLEQGIQ 971

  Fly  1062 DSRLTRHKFWLLVE--DLPGGQHVTQPPSYKVLSQQAQQLANALRYPPNLYFVSNLEQP--ELAA 1122
            |:::|.:.|.:|:|  .....:...:..||..|   ...:.::|...|.:...:....|  ||..
Human   972 DNKITANLFRILLEKRSAVNTEEEKKSVSYPSL---LSHITSSLMNHPVIPMANKFSSPTLELQG 1033

  Fly  1123 ALLPLVRLLPKGPLPCDVHLTTLRTLSDPELQLFPSASALLVLHRQGFDCSVSAGRELSMEAICP 1187
            ...||     :..||||:||..|||:.. ::....|..|.|:|||:||||.
Human  1034 EFSPL-----QSSLPCDIHLVNLRTIQS-KVGNGHSNEAALILHRKGFDCR-------------- 1078

  Fly  1188 LSSKGLG---NVQLGRL----SLHTIEATSLTGTEQKSSRESYHIRSLAEISLEPMELRTFNLTF 1245
            .||||.|   :...|::    .|:.....|||.:...........::::||:|.|||:.||.:..
Human  1079 FSSKGTGLFCSTTQGKILVQKLLNKFIVESLTPSSLSLMHSPPGTQNISEINLSPMEISTFRIQL 1143

  Fly  1246 R 1246
            |
Human  1144 R 1144

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Man-IIb	NP_001262614.1	PLN02701	148..1246	CDD:178304	376/1128 (33%)
		GH38N_AMII_GMII_SfManIII_like	167..514	CDD:212120	162/355 (46%)
		Alpha-mann_mid	508..596	CDD:286360	45/88 (51%)
		Glyco_hydro_38C	813..1241	CDD:285047	124/441 (28%)
MAN2A1	NP_002363.2	PLN02701	128..1144	CDD:178304	379/1152 (33%)
		GH38N_Man2A1	165..508	CDD:212131	162/355 (46%)
		Alpha-mann_mid	503..588	CDD:214875	45/87 (52%)
		Glyco_hydro_38C	754..1139	CDD:285047	124/444 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147918
Domainoid	1	1.000	95	1.000	Domainoid score	I7422
eggNOG	1	0.900	-	-		E1_KOG1959
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4542
OMA	1	1.010	-	-		QHG55783
OrthoDB	1	1.010	-	-		D1101882at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102728
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	8.570