Protein Alignment alpha-Man-IIb and MAN2A2

DIOPT Version :9

• Sequence 1: NP_001262614.1
• Gene: alpha-Man-IIb / 41913
• FlyBaseID: FBgn0026616
• Length: 1249
• Species: Drosophila melanogaster
• Sequence 2: NP_001307906.1
• Gene: MAN2A2 / 4122
• HGNCID: 6825
• Length: 1175
• Species: Homo sapiens
• Alignment Length: 1218
• Identity: 418/1218 - (34%)
• Similarity: 617/1218 - (50%)
• Gaps: 211/1218 - (17%)

  Fly    89 ETKSAQTSVSPEEQSEEQYTNSNWGDKCYELIQSNTNITASEEHSKFDFQPEWMRSKEYWDRGFE 153
            |.:.:..|:||::.   |:.....|.| .||    ..:|.||| ..||.....:     |.:||:
Human   103 EPRPSFFSISPQDC---QFALGGRGQK-PEL----QMLTVSEE-LPFDNVDGGV-----WRQGFD 153

  Fly   154 ERFDAQKKDKQRPPLKIIVVPHSHNDPGWLKTFTNYFQSDSRQILNLLVTKMQEYTDMTFIWSEI 218
            ..:|....|.:  .|::.|||||||||||:|||..|:...::.|||.:|:|:||.....|:|:|:
Human   154 ISYDPHDWDAE--DLQVFVVPHSHNDPGWIKTFDKYYTEQTQHILNSMVSKLQEDPRRRFLWAEV 216

  Fly   219 SFLQLWWDQAHPTKQRALKRLIDAGRIEITTGGWVMTDEANVHIYPMLDQLIEGHQWLKNNLNVT 283
            ||...|||..:..|:.|::||:..|::||.||||||.||||.|.:.::||||||||||:.||..|
Human   217 SFFAKWWDNINVQKRAAVRRLVGNGQLEIATGGWVMPDEANSHYFALIDQLIEGHQWLERNLGAT 281

  Fly   284 PKVGWSIDPFGHGSTVPYLLSGANFEGTIIQRIHYAWKQWFARQQSGDFIWKPYWRSRKDKDSEA 348
            |:.||::||||:.||:||||..||....:|||:|||.|:.||...|.:|:|:..|    |.||..
Human   282 PRSGWAVDPFGYSSTMPYLLRRANLTSMLIQRVHYAIKKHFAATHSLEFMWRQTW----DSDSST 342

  Fly   349 GSLLTHNMPFDIYSIKGSCGPHPFICLNFDFRKIPGEYTE--YSVKAQFITDDNLESKAQLLLEQ 411
             .:..|.|||..|.:..:|||.|.||..|||:::||....  :.|..:.||:.|:..:|.|||:|
Human   343 -DIFCHMMPFYSYDVPHTCGPDPKICCQFDFKRLPGGRINCPWKVPPRAITEANVAERAALLLDQ 406

  Fly   412 YARTASLFPHNVALIPVGDDFRYNKDREVDQQYQNYKKLIDHIMANRRLYNADIRFGTPSDYFEA 476
            |.:.:.||..||.|:|:||||||:|.:|.|.|:.||::|.|...:...|: ...:|||.||||:|
Human   407 YRKKSQLFRSNVLLVPLGDDFRYDKPQEWDAQFFNYQRLFDFFNSRPNLH-VQAQFGTLSDYFDA 470

  Fly   477 IKERM----KDHTPGFPTFKGDFFVYSDIFSEGRPAYWSGYFTTRPFYKLLSSELEHQLRSAEIV 537
            :.:|.    ....||||...||||.|:|    ....||:||:|:|||||.|...||..||.||::
Human   471 LYKRTGVEPGARPPGFPVLSGDFFSYAD----REDHYWTGYYTSRPFYKSLDRVLEAHLRGAEVL 531

  Fly   538 FTLAYNTARQAKRENAIKIYE-KNYELIINARRNLGLFQHHDAITGTSKAAVMRDYAMRLFESTQ 601
            ::||   |..|:|......|. .::.|:..|||.|||||||||||||:|.||:.||.:||..|..
Human   532 YSLA---AAHARRSGLAGRYPLSDFTLLTEARRTLGLFQHHDAITGTAKEAVVVDYGVRLLRSLV 593

  Fly   602 NMVKMQESCLELLLQKGQPRHH-----GFLLSEFERDNFNKLPRKMPIQMANGDESTPTVPAGEG 661
            |:.::.......|:...:..:|     .||..:..|.:.:.||.:..||:    :|:|..
Human   594 NLKQVIIHAAHYLVLGDKETYHFDPEAPFLQVDDTRLSHDALPERTVIQL----DSSPRF----- 649

  Fly   662 GAGGSSSSGSVGSFVLYNSLAQKRLEVVTLRVQHPNVKIVNDKGVELNHIQINPVWN-----ITD 721
                         .||:|.|.|:|..:|:|.|..|.|::::::|..| .:||:..|:     :.|
Human   650 -------------VVLFNPLEQERFSMVSLLVNSPRVRVLSEEGQPL-AVQISAHWSSATEAVPD 700

  Fly   722 TYE---------QGLGTSVSGTVGRIRTSTRQFEVMFVAELEPLSLSTYRVQVDEVNFKRNIATI 777
            .|:         .|||                     |.:|: |.|..:|.....|.       |
Human   701 VYQVSVPVRLPALGLG---------------------VLQLQ-LGLDGHRTLPSSVR-------I 736

  Fly   778 YCDDCTESQPASVSPPEEIESSPTSVFEARGKPAGDIQLENPHMRLLFDEKSGFLKTITRKNQKK 842
            |    ...:..|||   ..|:.|..|.::   ...|..|.|.:|::.|...:|.||:|.|.:::.
Human   737 Y----LHGRQLSVS---RHEAFPLRVIDS---GTSDFALSNRYMQVWFSGLTGLLKSIRRVDEEH 791

  Fly   843 ELLKPLQCNIKFAAY--RSAQFHSGAYLFKTDPEQS---EAEKEVLEGYTDMRIIITSGPIASDV 902
            |    .|.:::...|  |:::..||||||..|.|..   ..|..||.        :|.||..|:|
Human   792 E----QQVDMQVLVYGTRTSKDKSGAYLFLPDGEAKPYVPKEPPVLR--------VTEGPFFSEV 844

  Fly   903 TVIYGPFLAHTVRIFNTRTHLDAAIYVENDIDFEPPPKNRETELFMRFVTNIDNIAQAPMQRDPL 967
             |.|...:...||::|.......::.:.:.:|.......   ||.:...|:||:..
Human   845 -VAYYEHIHQAVRLYNLPGVEGLSLDISSLVDIRDYVNK---ELALHIHTDIDSQG--------- 896

  Fly   968 KEPVDAATMPELPVFYSDQNGFQYHERIKVPAIGIEGNYFPITSGAFIQDSRLRLTLLTTHAQGA 1032
                         :|::|.||||...|..:..:.::.|::|:...|:|||::.||||.|..|.|.
Human   897 -------------IFFTDLNGFQVQPRRYLKKLPLQANFYPMPVMAYIQDAQKRLTLHTAQALGV 948

  Fly  1033 ASYEPGQLEVMLDRRTLYDDYRGMGEGVVDSRLTRHKFWLLVEDLPGGQHVTQPPSYKVLSQQAQ 1097
            :|.:.|||||:||||.:.||.||:|:|:.|::.|.::|.||:|....|   ::|..:..|:...:
Human   949 SSLKDGQLEVILDRRLMQDDNRGLGQGLKDNKRTCNRFRLLLERRTVG---SEPDFFSKLAAMFR 1010

  Fly  1098 QL--------------ANALRYPPNLYFVSN--LEQPELAAALLPLVRLLPKGP----------- 1135
            .|              :::..||..|..:::  |..|.||   ||:.|:...||
Human  1011 GLIFHSSRSGNREVQDSHSTSYPSLLSHLTSMYLNAPALA---LPVARMQLPGPGLRSFHPLASS 1072

  Fly  1136 LPCDVHLTTLRTLSDPELQLFPSASALLVLHRQGFDCSVSAGRELSMEAICPLSSKGLGNVQLGR 1200
            ||||.||..||||...| ...|||...|:|||:||||.:.| :.|...  |..|.   |.|.||.
Human  1073 LPCDFHLLNLRTLQAEE-DTLPSAETALILHRKGFDCGLEA-KNLGFN--CTTSQ---GKVALGS 1130

  Fly  1201 LSLHTIEA-----TSLTGTEQKSSRESYHIRSLAEISLEPMELRTFNL 1243
            | .|.::.     ||||.....:|..     :..::.|||||:.||.|
Human  1131 L-FHGLDVVFLQPTSLTLLYPLASPS-----NSTDVYLEPMEIATFRL 1172

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Man-IIb	NP_001262614.1	PLN02701	148..1246	CDD:178304	403/1159 (35%)
		GH38N_AMII_GMII_SfManIII_like	167..514	CDD:212120	162/352 (46%)
		Alpha-mann_mid	508..596	CDD:286360	45/88 (51%)
		Glyco_hydro_38C	813..1241	CDD:285047	141/464 (30%)
MAN2A2	NP_001307906.1	PLN02701	136..1174	CDD:178304	407/1177 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147919
Domainoid	1	1.000	95	1.000	Domainoid score	I7422
eggNOG	1	0.900	-	-		E1_KOG1959
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55783
OrthoDB	1	1.010	-	-		D1101882at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102728
Panther	1	1.100	-	-	LDO	PTHR11607
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	8.720