Protein Alignment alpha-Man-IIb and Man2b2

DIOPT Version :10

• Sequence 1: NP_650494.2
• Gene: alpha-Man-IIb / 41913
• FlyBaseID: FBgn0026616
• Length: 1249
• Species: Drosophila melanogaster
• Sequence 2: NP_001128443.2
• Gene: Man2b2 / 360955
• RGDID: 1308840
• Length: 1004
• Species: Rattus norvegicus
• Alignment Length: 1229
• Identity: 291/1229 - (23%)
• Similarity: 444/1229 - (36%)
• Gaps: 404/1229 - (32%)

  Fly   165 RP--PLKIIVVPHSHNDPGWLKTFTNYFQSDSRQILNLLVTKMQEYTDMTFIWSEISFLQLWWD- 226
            ||  |::..||||||.|.||:.|.....::.:..:...:|.::.......||..|..|.:||||
  Rat    22 RPASPIRAFVVPHSHMDVGWVYTVQESMRAYAANVYTTVVEELVRGRQRRFIAVEQEFFRLWWDG 86

  Fly   227 QAHPTKQRALKRLIDAGRIEITTGGWVMTDEANVHIYPMLDQLIEGHQWLKNNLNVTPKVGWSID 291
            .|...:::.:::|:|.||:|...||.||.|||..|:...:.||.|||.:|.....:.|:..|.:|
  Rat    87 VASEQQKQQVRQLLDEGRLEFVLGGQVMHDEAVTHLDDQILQLTEGHGFLYETFGIRPQFSWHVD 151

  Fly   292 PFGHGSTVPYLLSGANFEGTIIQRIHYAWKQWFARQQSGDFIWKPYWRSRKDKDSEAGSLLTHNM 356
            |||..:|.|.|.:.|.|...:|.||.|..|......|...|:|     ......||...:.||.|
  Rat   152 PFGASATTPTLFALAGFNAHLISRIDYDLKDAMQEAQGLQFVW-----HGSPSLSEQQEIYTHVM 211

  Fly   357 PFDIYSIKGSCGPHPFICLNFDFRKIPGEYTE-------------YSVKAQFITDDNLESKAQLL 408
              |:||.   |.|.     :..|....|.|..             |...::.:|.||:...|:.|
  Rat   212 --DLYSY---CTPS-----HIPFSNRSGFYWNGVAVFPEPPPDGVYPNMSEPVTVDNIHLYAEAL 266

  Fly   409 LEQYARTASLF--PHNVALIPVGDDFRYNKDREVDQQYQNYKKLIDHIMANRRLYNADIRFGTPS 471
            :....:.|:.|  ||  .|.|.|.|.::   .....|:.|...|:::|......:...:::.|.:
  Rat   267 VANVKQRAAWFRTPH--VLWPWGCDKQF---FNASVQFDNMDPLLEYINNRSAQFGISVQYATLN 326

  Fly   472 DYFEAIKE-----RMKDHTPGFPTFKGDFFVYSDIFSEGRPAYWSGYFTTRPFYKLLSSELEHQL 531
            |||:|:.:     .::||        .||..||   ||.:.| |:|:||:|...|.|:.:....|
  Rat   327 DYFQALHDFNVTWDIRDH--------HDFLPYS---SEPQQA-WTGFFTSRSTLKGLARQASALL 379

  Fly   532 RSAEIVF----------TLAYNTARQAKRENAIKIYEKNYELIINARRNLGLFQHHDAITGTSKA 586
            .:.|.:|          ||....|.|..::....:.|               .|||||||||...
  Rat   380 YAGESMFTRYMWPHPRGTLDPTWALQQLQQLRWAVSE---------------VQHHDAITGTESP 429

  Fly   587 AVMRDYAMRLFESTQNMVKMQESCLELLLQKGQPRHHGFLLSEFERDNFNKLPRKMPIQMANGDE 651
            .|...|...|....:.:.|:..|     :...:|...|
  Rat   430 KVKNMYMEHLSMGMRGVHKLMAS-----IALDRPPGSG--------------------------- 462

  Fly   652 STPTVPAGEGGAGGSSSSGSVGSFVLYNSLAQKRLEVVTLRVQHPNVKIVNDKGVELNHIQINPV 716
             |.|.|.|        .|.||     ||.||.|...::||.|..|:|.:.::
  Rat   463 -TDTRPVG--------YSASV-----YNPLAWKITTIITLTVAFPSVSVTDE------------- 500

  Fly   717 WNITDTYEQGLGTSVSGTVGRIRTSTRQ---FEVMFVAELEPLSLSTYRVQVDEVNFKRNIATIY 778
                      ||..||   .:|:.||:.   ::::.:..:..||...|:|:
  Rat   501 ----------LGRPVS---AQIQNSTKDPSAYDLLILTTIPGLSYRHYKVR-------------- 538

  Fly   779 CDDCTESQPASVSPPEEIESSPTSVFEARGKPAGDIQLENPHMR--------------------- 822
                                      ..||..||..:|..|...
  Rat   539 --------------------------RTRGDQAGTRELVTPRANTLKFSRKLRNQTSQEGKLLVP 577

  Fly   823 -------LLFDEKSGFLKTITRKNQKKELLKPLQCNIKFAAYR-SAQFHSGA----YLFKTDPEQ 875
                   ||||:.:..|.:|    |.::..:.:....:|..|| :.....|.    |||.:: :.
  Rat   578 VMNDCYTLLFDQDTNMLHSI----QDRQSNRTVHMTQEFLEYRANGDVKQGPISDNYLFASN-DT 637

  Fly   876 SEAEKEVLEGYTDMRIIITSGPIASDVTVIYGPFLAHTVRIFNTRTHLDAAIY-----------V 929
            :|...|.:    .|.:::  |.:|:||...:...:.....|::..|.| |.::           :
  Rat   638 AEPSWEAV----GMEMVV--GTLATDVRQYFYRNITDQGYIYSIHTRL-AHVHPSLAGELLCRRI 695

  Fly   930 ENDIDFEPPPKNRETELFMRFVTNIDNIAQAPMQRDPLKEPVDAATMPELPVFYSDQNGFQYHER 994
            |......|...|||..|    .|:.|..:|                    .|.|||.||:|...|
  Rat   696 EQQYQVGPLDLNREAIL----RTSSDLNSQ--------------------QVLYSDNNGYQMQRR 736

  Fly   995 IKVP-----AIGIEGNYFPITSGAFIQDSRLRLTLLTTHAQGAASYEPGQLEVMLDRR------- 1047
               |     :..|..||:|:...|||:|.:.||.||.....|.:|.|.||:||||.||
  Rat   737 ---PYKAFKSNPIPRNYYPMVQSAFIEDDKSRLVLLAERPHGVSSQENGQVEVMLHRRLWNNLVW 798

  Fly  1048 ------TLYDD-------YRGMGEGVVDSRL-------TRHKFWLLVEDLPGGQH---------- 1082
                  ||.|.       :..:|.....:.|       .:|:..:|:::|...:.
  Rat   799 DLNYNLTLNDTSVVHPVLWLLLGPKSTTTALRPRSGVALQHRPVVLLKELTDEEETAIHRPHHPW 863

  Fly  1083 -VTQPPS--YKVLS--------QQAQQLANALRYPPNLYFVSNLEQPE--LAAALLPLVRLLPKG 1134
             ||.|||  .:|||        ..||.|.|..|..|        |:|:  |...||.|..|...|
  Rat   864 PVTLPPSLHLQVLSLPGWQYSRNHAQHLKNLQRGHP--------EKPQVNLQRVLLRLHHLYEAG 920

  Fly  1135 PLPCDVHLTTLRTLSDPELQLFPSASALLVLHRQGFDCSVSAGRELSMEAICPLSSKGLGNVQLG 1199
                          .||.|    |..|.:.|                     .::.:|||:|.
  Rat   921 --------------EDPVL----SRPATVDL---------------------KIALRGLGSVV-- 944

  Fly  1200 RLSLHTIEATSLTGTEQKSSRESYHIRSL-----------------AEISLEPMELRTF 1241
                 .:|..|||||....:.:.:|.|:.                 :.|::.|.|:|||
  Rat   945 -----AVEERSLTGTWDVQTLQRWHWRTKIGQLKGHPTSPPRSPGGSIITVYPKEIRTF 998

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Man-IIb	NP_650494.2	PLN02701	148..1246	CDD:178304	291/1229 (24%)
Man2b2	NP_001128443.2	PLN02701	27..792	CDD:178304	233/962 (24%)
		GH38N_AMII_Epman_like	27..352	CDD:212122	100/355 (28%)