Protein Alignment alpha-Man-IIb and Man2a2

DIOPT Version :10

• Sequence 1: NP_650494.2
• Gene: alpha-Man-IIb / 41913
• FlyBaseID: FBgn0026616
• Length: 1249
• Species: Drosophila melanogaster
• Sequence 2: NP_001425115.1
• Gene: Man2a2 / 308757
• RGDID: 1310238
• Length: 1175
• Species: Rattus norvegicus
• Alignment Length: 1210
• Identity: 413/1210 - (34%)
• Similarity: 620/1210 - (51%)
• Gaps: 195/1210 - (16%)

  Fly    89 ETKSAQTSVSPEEQSEEQYTNSNWGDKCYELIQSNTNITASEEHSKFDFQPEWMRSKE--YWDRG 151
            |.:.:..|||||:.   |:.....|.| .||    ..:|.||: ..||       :.|  .|.:|
  Rat   103 EPRPSFFSVSPEDC---QFALGGRGQK-PEL----QMLTVSED-LPFD-------NVEGGVWRQG 151

  Fly   152 FEERFDAQKKDKQRPPLKIIVVPHSHNDPGWLKTFTNYFQSDSRQILNLLVTKMQEYTDMTFIWS 216
            |:..:.....|.:  .|::.|||||||||||:|||..|:...::.|||.:|:|:||.....|:|:
  Rat   152 FDISYSPNDWDAE--DLQVFVVPHSHNDPGWIKTFDKYYTEQTQHILNSMVSKLQEDPRRRFLWA 214

  Fly   217 EISFLQLWWDQAHPTKQRALKRLIDAGRIEITTGGWVMTDEANVHIYPMLDQLIEGHQWLKNNLN 281
            |:||...|||.....|:.|::||:..|::||.||||||.||||.|.:.::||||||||||:.||.
  Rat   215 EVSFFAKWWDNISAQKRAAVRRLVGNGQLEIATGGWVMPDEANSHYFALVDQLIEGHQWLERNLG 279

  Fly   282 VTPKVGWSIDPFGHGSTVPYLLSGANFEGTIIQRIHYAWKQWFARQQSGDFIWKPYWRSRKDKDS 346
            .||:.||::|||||.||:||||..||....:|||:|||.|:.||...|.:|:|:..|    |.||
  Rat   280 ATPRSGWAVDPFGHSSTMPYLLRRANLTSMLIQRVHYAIKKHFAATHSLEFMWRQTW----DSDS 340

  Fly   347 EAGSLLTHNMPFDIYSIKGSCGPHPFICLNFDFRKIPGEYTE--YSVKAQFITDDNLESKAQLLL 409
            .. .:..|.|||..|.:..:|||.|.||..|||:::||....  :.|..:.||:.|:..:|.|||
  Rat   341 ST-DIFCHMMPFYSYDVPHTCGPDPKICCQFDFKRLPGGRINCPWKVPPRAITEANVADRAALLL 404

  Fly   410 EQYARTASLFPHNVALIPVGDDFRYNKDREVDQQYQNYKKLIDHIMANRRLYNADIRFGTPSDYF 474
            :||.:.:.||..:|.|:|:||||||:|.:|.|.|:.||::|.| .:.::..::...:|||.|:||
  Rat   405 DQYRKKSRLFRSSVLLVPLGDDFRYDKPQEWDAQFFNYQRLFD-FLNSKPEFHVQAQFGTLSEYF 468

  Fly   475 EAIKERM----KDHTPGFPTFKGDFFVYSDIFSEGRPAYWSGYFTTRPFYKLLSSELEHQLRSAE 535
            :|:.:|.    ....||||...||||.|:|    ....||:||:|:|||||.|...||..||.||
  Rat   469 DALYKRTGVEPGARPPGFPVLSGDFFSYAD----REDHYWTGYYTSRPFYKSLDRVLETHLRGAE 529

  Fly   536 IVFTLAYNTARQAKRENAIKIYEKNYELIINARRNLGLFQHHDAITGTSKAAVMRDYAMRLFEST 600
            ::::||...||::.......:  .:|.::..|||.|||||||||||||:|.||:.||.:||..|
  Rat   530 VLYSLALAHARRSGLTGQYPL--SDYAVLTEARRTLGLFQHHDAITGTAKEAVVVDYGVRLLRS- 591

  Fly   601 QNMVKMQESCLELLLQKGQPRHHGFLLSEFERDNFNKLPRKMPIQMANGDESTPTVPAGEGGAGG 665
              :|.:::..:...        |..:|.:.|..:|:  ||...:||.:...|...:|  |.....
  Rat   592 --LVSLKQVIINAA--------HYLVLGDKETYSFD--PRAPFLQMDDSRVSHDALP--ERTVIR 642

  Fly   666 SSSSGSVGSFVLYNSLAQKRLEVVTLRVQHPNVKIVNDKGVELNHIQINPVWN-----ITDTYE- 724
            ..||...  .|::|.|.|:||.||:|.|..|.|::::::|..|: :||:..|:     :.|.|:
  Rat   643 LDSSPRF--VVVFNPLEQERLSVVSLLVNSPRVRVLSEEGQPLS-VQISVQWSSATNMVPDVYQV 704

  Fly   725 --------QGLGTSVSGTVGRIRTSTRQFEVMFVAELEPLSLSTYRVQVDEVNFKRNIATIYCDD 781
                    .|||                     |.:|:|.....|.:|        :...:|.:.
  Rat   705 SVPVRLPALGLG---------------------VLQLQPDLDGPYTLQ--------SSVHVYLNG 740

  Fly   782 CTESQPASVSPPEEIESSPTSVFEARGKPAGDIQLENPHMRLLFDEKSGFLKTITRKNQKKELLK 846
            ...|.....:.|..:..|.||          |..:.|.:|::.|...:|.||::.|.::::|
  Rat   741 VKLSVSRQTTFPLRVVDSGTS----------DFAISNRYMQVWFSGLTGLLKSVRRVDEEQE--- 792

  Fly   847 PLQCNIKFAAY--RSAQFHSGAYLFKTDPEQSEAEKEVLEGYTDMRIIITSGPIASDVTVIYGPF 909
             .|.::|...|  |:::..||||||..|   :||:..|.:....:|  :|.||..|:|...|..|
  Rat   793 -QQVDMKLFVYGTRTSKDKSGAYLFLPD---NEAKPYVPKKPPVLR--VTEGPFFSEVAAYYEHF 851

  Fly   910 LAHTVRIFNTRTHLDAAIYVENDIDFEPPPKNR-ETELFMRFVTNIDNIAQAPMQRDPLKEPVDA 973
             ...:|::|    |.....:..|:.|:...::. ..||.:|..|:||:..
  Rat   852 -HQVIRLYN----LPGVEGLSLDVSFQVDIRDYVNKELALRIHTDIDSQG--------------- 896

  Fly   974 ATMPELPVFYSDQNGFQYHERIKVPAIGIEGNYFPITSGAFIQDSRLRLTLLTTHAQGAASYEPG 1038
                   .|::|.||||...|..:..:.::.|::|:...|:||||:.||||.|..|.|.:|...|
  Rat   897 -------TFFTDLNGFQVQPRKYLKKLPLQANFYPMPVMAYIQDSQRRLTLHTAQALGVSSLGNG 954

  Fly  1039 QLEVMLDRRTLYDDYRGMGEGVVDSRLTRHKFWLLVEDLPGGQHVTQPPSYKVLSQQAQQL---- 1099
            ||||:||||.:.||.||:|:|:.|:::|.:.|.||:|     :.....|.....|:.|...
  Rat   955 QLEVILDRRLMQDDNRGLGQGLKDNKITCNHFRLLLE-----RRTLMSPEPGFFSKLAAMFRGLI 1014

  Fly  1100 --ANALR-----------YPPNLYFVSN--LEQPELAAALLPLVR----------LLP-KGPLPC 1138
              :|.:|           ||..|..:::  |..|.|   :||:.:          ..| ..||||
  Rat  1015 FSSNTIRNSKVQQERSTSYPSLLSHMTSMYLNTPPL---VLPVAKRESTSPTLHSFHPLASPLPC 1076

  Fly  1139 DVHLTTLRTLSDPELQLFPSASALLVLHRQGFDCSVSAGRELSMEAICPLSSKGLGNVQLGRLSL 1203
            |.||..||.|  |.....|:|.|.|:|||:||||.:.| :.|............||::..| |.:
  Rat  1077 DFHLLNLRML--PAEDTLPAADAALILHRKGFDCGLEA-KNLGFNCTTSQGKLALGSLFHG-LDV 1137

  Fly  1204 HTIEATSLTGTEQKSSRESYHIRSLAEISLEPMELRTFNL 1243
            ..::.||||.....:|..     :..:|||||||:.||.|
  Rat  1138 LFLQPTSLTLLYPLASPS-----NSTDISLEPMEISTFRL 1172

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Man-IIb	NP_650494.2	PLN02701	148..1246	CDD:178304	396/1149 (34%)
Man2a2	NP_001425115.1	None