Protein Alignment alpha-Man-IIb and Man2a1

DIOPT Version :10

• Sequence 1: NP_650494.2
• Gene: alpha-Man-IIb / 41913
• FlyBaseID: FBgn0026616
• Length: 1249
• Species: Drosophila melanogaster
• Sequence 2: NP_037111.2
• Gene: Man2a1 / 25478
• RGDID: 3038
• Length: 1148
• Species: Rattus norvegicus
• Alignment Length: 1252
• Identity: 415/1252 - (33%)
• Similarity: 638/1252 - (50%)
• Gaps: 194/1252 - (15%)

  Fly    51 RGSPLSGLTGFSVDGGSSSIIHQQKQQL--VIASNQKKSSETKSA--QTSVSPEEQSEEQYTNSN 111
            ||....|    |...|..||:.::...|  ::|.|.:..|..:.:  ..|.|.|:.......|::
  Rat    35 RGPRQEG----SFPQGQLSILQEKIDHLERLLAENNEIISNIRDSVINLSESVEDGPRGPAGNAS 95

  Fly   112 WGD---------------KCYELIQSNTNITASEEHSKFDFQPEWMRSKEYWDRGFEERFDAQKK 161
            .|.               .|....||.......:....:|..|........|.:||:.:::|.:.
  Rat    96 QGSAHLHSAQLALQADPKDCLFASQSGNQHRDVQMLDVYDLIPFDNPDGGVWKQGFDIKYEADEW 160

  Fly   162 DKQRPPLKIIVVPHSHNDPGWLKTFTNYFQSDSRQILNLLVTKMQEYTDMTFIWSEISFLQLWWD 226
            |  |.||::.|||||||||||||||.:||:..::.|.|.:|.|::|.:...|||||||:|..|||
  Rat   161 D--REPLQVFVVPHSHNDPGWLKTFNDYFRDKTQYIFNNMVLKLKEDSSRKFIWSEISYLAKWWD 223

  Fly   227 QAHPTKQRALKRLIDAGRIEITTGGWVMTDEANVHIYPMLDQLIEGHQWLKNNLNVTPKVGWSID 291
            .....|:.|:|.|:..|::||.||||||.|||..|.:.::||||||||||:.||.|.|:.||:||
  Rat   224 IIDNPKKEAVKSLLQNGQLEIVTGGWVMADEATTHYFALIDQLIEGHQWLEKNLGVKPRSGWAID 288

  Fly   292 PFGHGSTVPYLLSGANFEGTIIQRIHYAWKQWFARQQSGDFIWKPYWRSRKDKDSEAGS---LLT 353
            ||||..|:.|||..|.|...:|||:||:.|:.|:.|::.:|.|:..|        :.||   :|.
  Rat   289 PFGHSPTMTYLLKRAGFSHMLIQRVHYSVKKHFSLQKTLEFFWRQNW--------DLGSTTDILC 345

  Fly   354 HNMPFDIYSIKGSCGPHPFICLNFDFRKIP-GEY-TEYSVKAQFITDDNLESKAQLLLEQYARTA 416
            |.|||..|.|..:|||.|.||..|||:::| |.| ..:.|..:.|:..|::|:||:||:||.:.:
  Rat   346 HMMPFYSYDIPHTCGPDPKICCQFDFKRLPGGRYGCPWGVPPEAISPGNVQSRAQMLLDQYRKKS 410

  Fly   417 SLFPHNVALIPVGDDFRYNKDREVDQQYQNYKKLIDHIMANRRLYNADIRFGTPSDYFEAIKERM 481
            .||...|.|.|:|||||:::..|.|.||:||::|..::.:...| ...|:|||.||||:|:::.:
  Rat   411 KLFRTKVLLAPLGDDFRFSEYTEWDLQYRNYEQLFSYMNSQPHL-KVKIQFGTLSDYFDALEKSV 474

  Fly   482 KDHTPG----FPTFKGDFFVYSDIFSEGRPAYWSGYFTTRPFYKLLSSELEHQLRSAEIVFTLAY 542
            .....|    ||...||||.|:|....    |||||||:|||||.:...:|.:||:|||::.||.
  Rat   475 AAEKKGGQSVFPALSGDFFTYADRDDH----YWSGYFTSRPFYKRMDRIMESRLRTAEILYHLAL 535

  Fly   543 NTARQAKRENAIKIYEKNYELIINARRNLGLFQHHDAITGTSKAAVMRDYAMRLFESTQNMVKMQ 607
            ..|::.|....:.  ..:|..:..|||||||||||||||||:|..|:.||..|||:|..::.|:.
  Rat   536 KQAQKYKINKFLS--SPHYTTLTEARRNLGLFQHHDAITGTAKDWVVVDYGTRLFQSLNSLEKII 598

  Fly   608 ESCLELLLQKGQPRHH-----GFLLSEFERDNFNKLPRKMPIQMANGDESTPTVPAGEGGAGGSS 667
            .....||:.|.:..:.     .||..:.::.:.:.||:|..||:
  Rat   599 GDSAFLLILKDKKLYQSDPSKAFLEMDTKQSSQDSLPKKNIIQL--------------------- 642

  Fly   668 SSGSVGSFVLYNSLAQKRLEVVTLRVQHPNVKIVND--KGVELNHIQINPVWNITDTYEQGLGTS 730
            |:......|:||...|:|..||::||....||:::|  |.||   :|::.||....|
  Rat   643 SAQEPRYLVVYNPFEQERHSVVSVRVNSATVKVLSDLGKAVE---VQVSAVWKDMRT-------- 696

  Fly   731 VSGTVGRIRTSTRQFEVMFVAELEPLSLSTYRVQVDEVNFKRNIAT--IYCDDCTESQPASVSPP 793
                     ||...:||.|:|.|.||.|..|:: ::..:...::|.  :|.:|
  Rat   697 ---------TSQAAYEVAFLAHLPPLGLKVYKI-LESQSSSSHLADYFLYNND------------ 739

  Fly   794 EEIESSPTSVFEARGK-PAGD-IQLENPHMRLLFDEKSGFLKTITRK--NQKKELLKPLQCNIKF 854
               ..:.:.:|..:.. .:|| |.:||..:.|.|| :||.::.:.||  |:::||      .::|
  Rat   740 ---GQAESGIFHMKNMVDSGDAITIENSFLTLGFD-RSGLMEKVRRKEDNKQQEL------KVQF 794

  Fly   855 AAY--RSAQFHSGAYLFKTDPEQSEAEKEVLEGYTDMR---IIITSGPIASDVTVIYGPFLAHTV 914
            ..|  .:.:..||||||..|.:.        :.|..:|   :.:|.|.|.|||| .:...:.|.|
  Rat   795 LWYGTTNKRDKSGAYLFLPDGQG--------QPYVSLRTPFVRVTRGRIYSDVT-CFLEHVTHKV 850

  Fly   915 RIFNTRTHLDAAIYVENDIDFEPPPKNRETELFMRFVTNIDNIAQAPMQRDPLKEPVDAATMPEL 979
            |:::.:.....::.|.|.:|.. ...||  |:.||..:.|:|..:
  Rat   851 RLYHIQGIEGQSMEVSNIVDIR-SVHNR--EIVMRISSKINNQNR-------------------- 892

  Fly   980 PVFYSDQNGFQYHERIKVPAIGIEGNYFPITSGAFIQDSRLRLTLLTTHAQGAASYEPGQLEVML 1044
              :|:|.||:|...|..:..:.::.|.:|:::.|:|||:..|||||:..:.||:|...||:||.:
  Rat   893 --YYTDLNGYQIQPRRTMAKLPLQANVYPMSTMAYIQDAAHRLTLLSAQSLGASSMASGQIEVFM 955

  Fly  1045 DRRTLYDDYRGMGEGVVDSRLTRHKFWLLVEDLPG---GQHVTQPPSYKVLSQQAQQLANALRYP 1106
            |||.:.||.||:|:||.|:::|.:.|.:|:|...|   .:....|.||..|   ...:.:|....
  Rat   956 DRRLMQDDNRGLGQGVHDNKITANLFRILLEKRNGMNMEEDKKSPVSYPSL---LSHMTSAFLNH 1017

  Fly  1107 PNLYFVSNLEQPELAAALLPLVRLLPKGPLPCDVHLTTLRTLSDPELQLFPSASALLVLHRQGFD 1171
            |.|..|.:.:.|..|..||...||| :..||||:||..|||:.....:.: |..|.|:|||:.||
  Rat  1018 PFLPMVLSGQLPSPAIELLSEFRLL-QSSLPCDIHLVNLRTIQSKVGKGY-SDEAALILHRKVFD 1080

  Fly  1172 CSVSAGRELSMEAICPLSSKGLG---NVQLGRLSLHTIEATSLTGTEQKSSRESYH----IRSLA 1229
            |.              |||:.:|   :...|::|:..:.......:...||....|    .::.:
  Rat  1081 CQ--------------LSSRAMGLPCSTTQGKMSIPKLFNNFAVESFIPSSLSLMHSPPDAQNTS 1131

  Fly  1230 EISLEPMELRTFNLTFR 1246
            |:||.|||:.|..:..|
  Rat  1132 EVSLSPMEISTSRIRLR 1148

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Man-IIb	NP_650494.2	PLN02701	148..1246	CDD:178304	393/1134 (35%)
Man2a1	NP_037111.2	PLN02701	127..1148	CDD:178304	395/1154 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1121..1148		8/26 (31%)