DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Man-IIb and aman-1

DIOPT Version :9

Sequence 1:	NP_001262614.1	Gene:	alpha-Man-IIb / 41913	FlyBaseID:	FBgn0026616	Length:	1249	Species:	Drosophila melanogaster
Sequence 2:	NP_508811.1	Gene:	aman-1 / 180749	WormBaseID:	WBGene00018877	Length:	955	Species:	Caenorhabditis elegans

Alignment Length:	1071	Identity:	261/1071 - (24%)
Similarity:	406/1071 - (37%)	Gaps:	312/1071 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   160 KKDKQRPPLKIIVVPHSHNDPGWLKTFTNYFQSDS--------RQILNLLVTKMQEYTDMTFIWS 216
            |.|:....:...::||:|:|.||:||...||....        :.|.|.::.::.:..|..|.::
Worm    28 KVDQDPNVITAHLIPHTHDDLGWIKTVDQYFWGAKPELVPVGVQYIYNTVIDELLKNPDRRFSFA 92

  Fly   217 EISFLQLWWDQAHPTKQRALKRLIDAGRIEITTGGWVMTDEANVHIYPMLDQLIEGHQWLKNNLN 281
            |..||..|:.......:..|::|:..|:|||..||||..|||..|...::||:..|.|.|:....
Worm    93 ETGFLWRWYTSNSDFDRHQLQKLVKNGQIEIIGGGWVQNDEATSHYVDIIDQMTLGLQRLEQIFG 157

  Fly   282 V--TPKVGWSIDPFGHGSTVPYLLSGANFEGTIIQRIHYAWKQWFARQQSGDFIWKPYWRSRKDK 344
            .  .|..||.||||||...:..:.....:......||||..||...:.::.:|:|.   .|....
Worm   158 ECGKPVTGWQIDPFGHSREMANIYREMGYSSVYFARIHYLEKQIRLKNKTLEFMWN---TSDDIT 219

  Fly   345 DSE--AGSLLTHNM-PFDIYSIKGSCGPHPFICLNFDFRKIPGEYTEYSVKAQFITDDNLESKAQ 406
            |::  .|:....|. |.:.:.....||..|.:    |...|.|    |:||          .|..
Worm   220 DNKLFTGAFFNDNYGPPEGFCWDSLCGDDPIM----DNLNIEG----YNVK----------EKVD 266

  Fly   407 LLLEQYARTASLFPHNVALIPVGDDFRYNKDREVDQQYQNYKKLIDHIMANRRLYNAD------I 465
            ..::.....|:....|..::.:|.||:|.   ..:..|.|..|||.::       |||      :
Worm   267 AFVDHVKNQAAHQSTNQVMLLMGSDFQYT---NANSWYVNLDKLIKYV-------NADTSKKVRV 321

  Fly   466 RFGTPSDYFEAIKERMKDHTPGFPTFKGDFFVYSDIFSEGRPAYWSGYFTTRPFYKLLSSELEHQ 530
            .:.||:.|.:|::.:    ||.......|||.|    :.||.:||:||||:||.:|       ..
Worm   322 IYSTPACYTKAVQAK----TPTLSVKHDDFFPY----ASGRHSYWTGYFTSRPAFK-------GM 371

  Fly   531 LRSAEIVFTLAYNTARQAKRENAIKIYEKNYELIIN-----------ARRNLGLFQHHDAITGTS 584
            :|.|..:..||                 |..::|.|           .|....|.|||||:|||:
Worm   372 IRQASCMLQLA-----------------KQLDVIANLGPEDDSDIEILREASALVQHHDAVTGTA 419

  Fly   585 KAAVMRDYAMRLFESTQNMVKMQESCLELLLQKGQPRHHGFLLSEFERDNFNKLPRKMPIQMANG 649
            |..|.|||..:|.:....:    |..:...::|..|            |..:  |:.:...:.|.
Worm   420 KENVTRDYEKQLAKGVSEV----EVVINDFMKKMNP------------DGLD--PKLVLCPLINE 466

  Fly   650 DESTPTVPAGEGGAGGSSSSGSVGSFVLYNS------------LAQKRLEVVTLRVQHPNVKIVN 702
            ....|        ..|||..    |.|::||            .:||   ...||..|.||
Worm   467 TICKP--------INGSSEF----SVVIFNSNGRYFNGTIRIPYSQK---TAVLRDAHKNV---- 512

  Fly   703 DKGVELNHIQINPVWNITDTYEQGLGTSVSGTVGRIRTSTR-QFEVMFVAELEPLSLSTYRVQVD 766
               :|.         .|.:|::          :.:::.:.| .:|:.....:.||..:|..|:
Worm   513 ---LES---------QIVETFQ----------IDQLKDTDRLPYEIHVFVRVPPLGYTTVFVE-- 553

  Fly   767 EVNFKRNIATIYCDDCTESQPASVSPPEEIESSPTSVFEARGKPAGDIQLENPHMRLLFDEKSGF 831
                                  ..|.||.:.      |..|.|...:::::|.::...||.: |:
Worm   554 ----------------------KGSKPERVH------FNNRKKFNTNVEIQNEYLIAGFDSQ-GY 589

  Fly   832 LKTITRKNQKKELLKPLQCNIKFAAYRSAQFH-----------SGAYLFKTDPEQSEA--EKEVL 883
            |..||.|..||:           .:.|...|:           ||||:|:...:|..|  .|..|
Worm   590 LSYITEKATKKK-----------RSIRQEFFYYEGIDSKDDQPSGAYIFRPKTQQPIALTSKLAL 643

  Fly   884 EGYTDMRIIITSGPIASDVTVIYGPFLAHTVRIFNTRTHLDAAIYVENDIDFE----PPPKNRET 944
            |        :..|.|.::|.....||::..:|:...:          |.|:||    |.||..:.
Worm   644 E--------VVPGAIINEVRQKVSPFVSQQIRLPRGK----------NYIEFEWIVGPIPKETKN 690

  Fly   945 ELFMRFVTNIDNIAQAPMQRDPLKEPVDAATMPELPVFYSDQNGFQYHERIKVPAIGIE------ 1003
            .:...|||.......:..|.                  ::|.||.|..||....|...|
Worm   691 PITKEFVTRYTTEVHSKNQS------------------FTDSNGRQAMERFFDGATSFEYSDTEP 737

  Fly  1004 --GNYFPITSGAFIQDSRLRLTLLTTHAQGAASYEPGQLEVMLDRRTLYDDYRGMGEGVVDSRLT 1066
              |||:||||..:|:|...:.:::|..|||..:.: |.:|:||.||..|||:.|:.|.:
Worm   738 IAGNYYPITSFGYIKDENAQFSVITDRAQGMVASD-GVVEIMLHRRCFYDDHFGVEEAL------ 795

  Fly  1067 RHKFWLLVEDLPG---------GQHVTQPPSYKVLSQQAQQLANALRYPPNLYFVSNLEQPELAA 1122
                     |.||         |:|:......|..:.|.:.||           :.|..||.||.
Worm   796 ---------DEPGKDGAGLVAMGKHIVLFTDVKASTSQLRPLA-----------IDNFHQPVLAF 840

  Fly  1123 ALLP----LVRLLP----KGPLPCDVHLTTL 1145
            ...|    ..|||.    |..||..:||.||
Worm   841 NKNPEKFEFNRLLEYSGLKFELPIGIHLLTL 871

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Man-IIb	NP_001262614.1	PLN02701	148..1246	CDD:178304	261/1071 (24%)
		GH38N_AMII_GMII_SfManIII_like	167..514	CDD:212120	98/365 (27%)
		Alpha-mann_mid	508..596	CDD:286360	31/98 (32%)
		Glyco_hydro_38C	813..1241	CDD:285047	96/375 (26%)
aman-1	NP_508811.1	GH38N_AMII_LAM_like	36..313	CDD:212121	80/307 (26%)
		Alpha-mann_mid	357..431	CDD:286360	31/97 (32%)
		Glyco_hydro_38C	537..944	CDD:285047	106/440 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1959
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810