Protein Alignment alpha-Man-IIb and Man2b2

DIOPT Version :9

• Sequence 1: NP_001262614.1
• Gene: alpha-Man-IIb / 41913
• FlyBaseID: FBgn0026616
• Length: 1249
• Species: Drosophila melanogaster
• Sequence 2: NP_032576.2
• Gene: Man2b2 / 17160
• MGIID: 1195262
• Length: 1018
• Species: Mus musculus
• Alignment Length: 1210
• Identity: 283/1210 - (23%)
• Similarity: 443/1210 - (36%)
• Gaps: 348/1210 - (28%)

  Fly   167 PLKIIVVPHSHNDPGWLKTFTNYFQSDSRQILNLLVTKMQEYTDMTFIWSEISFLQLWWD-QAHP 230
            |::..||||||.|.||:.|.....::.:..:...:|.::.......||..|..|.:|||| .|..
Mouse    26 PIRAFVVPHSHMDVGWVFTVQESMRAYAANVYTTVVAELVRGGQRRFIAVEQEFFRLWWDGVASE 90

  Fly   231 TKQRALKRLIDAGRIEITTGGWVMTDEANVHIYPMLDQLIEGHQWLKNNLNVTPKVGWSIDPFGH 295
            .:::.:::|:..||:|...||.||.|||..|:...:.||.|||.:|.....:.|:..|.:||||.
Mouse    91 QQKQQVRQLLHEGRLEFVLGGQVMHDEAVTHLDDQILQLTEGHGFLYETFGIRPQFSWHVDPFGA 155

  Fly   296 GSTVPYLLSGANFEGTIIQRIHYAWKQWFARQQSGDFIW--KPYWRSRKDKDSEAGSLLTHNMPF 358
            .:|.|.|.:.|.|...:|.||.|..|......|...|:|  .|....:::       :.||.|
Mouse   156 SATTPTLFALAGFNAHLISRIDYDLKDAMQEAQMLQFVWHGSPSLSGQQE-------IFTHVM-- 211

  Fly   359 DIYSIKGSCGPHPFICLNFDFRKIPGEYTE-------------YSVKAQFITDDNLESKAQLLLE 410
            |.||.   |.|.     :..|....|.|..             |...::.:|..|:...|:.|:.
Mouse   212 DHYSY---CTPS-----HIPFSNRSGFYWNGVAVFPEPPPDGVYPNMSEPVTGANIHLYAEALVA 268

  Fly   411 QYARTASLF--PHNVALIPVGDDFRYNKDREVDQQYQNYKKLIDHIMANRRLYNADIRFGTPSDY 473
            ...:.|:.|  ||  .|.|.|.|.::   .....|:.|...|:|:|......:...:::.|.:||
Mouse   269 NVKQRAAWFRTPH--VLWPWGCDKQF---FNASVQFDNMDPLLDYINQRTAQFGISVQYATLNDY 328

  Fly   474 FEAIKER-----MKDHTPGFPTFKGDFFVYSDIFSEGRPAYWSGYFTTRPFYKLLSSELEHQLRS 533
            |:|:...     ::||.        ||..||   ||...| |:|::|:|...|.|:.:....|.:
Mouse   329 FQALHATNMTWGIRDHQ--------DFLPYS---SEPLQA-WTGFYTSRSTLKGLARQASALLYA 381

  Fly   534 AEIVF----------TLAYNTARQAKRENAIKIYEKNYELIINARRNLGLFQHHDAITGTSKAAV 588
            .|.:|          ||....|.|..::....:.|               .|||||||||....|
Mouse   382 GESMFTRYMWPDPSGTLDPTWALQQLQQLRWAVSE---------------VQHHDAITGTESPKV 431

  Fly   589 MRDYAMRLFESTQNMVKMQESCLELLLQKGQPRHHGFLLSEFERDNFNKLPRKMPIQMANGDEST 653
            ...|...|   ...|:.:::..:.:.|  |.|...|           ...|:.:     .|.:.|
Mouse   432 KNMYTEHL---RMGMLGVRKLMVSIAL--GGPPGSG-----------TGAPKDI-----MGPQVT 475

  Fly   654 PTVPAGEGGAGGSSSSGSVGSFVLYNSLAQKRLEVVTLRVQHPNVKIVNDKGVELNHIQINPVWN 718
            |.:.......|.|:|        :||.||.|...::||.|..|||.:.:    ||.|.....:.|
Mouse   476 PVLSVDTRPVGYSAS--------VYNPLAWKITTIITLTVAFPNVSVTD----ELGHPVSTQIQN 528

  Fly   719 IT---DTYEQGLGTSVSGTVGRIRTSTRQFEVMFVAELEPLSLSTYRVQVDEVNFKRNIA----T 776
            .|   ..|:..:.|::.|      .:.|.::||             ..:.|:...:..:|    |
Mouse   529 STKDPSAYDLLILTTIPG------LNYRHYQVM-------------HARGDQAGTRELVAPRANT 574

  Fly   777 IYCDDCTESQPASVSPPEEIESSPTSVFEARGKPAGDIQLENPHMRLLFDEKSGFLKTITRKNQK 841
            :.......:||:.                 .||..  :.:.|....||||:.:..|.:|    |.
Mouse   575 LKFSLKLRNQPSQ-----------------EGKRL--VPVMNDCYILLFDQDTNMLHSI----QD 616

  Fly   842 KELLKPLQCNIKFAAYRSAQFH------SGAYLF----KTDPEQSEAEKEVLEGYTDMRIIITSG 896
            ::..:.::...:|..|: |.:.      |..|||    ..:|.......|::           :|
Mouse   617 RQSNRTVRMTQEFLEYQ-ANWDVKQGPISDNYLFAPNNTAEPSWEAVGMEMV-----------AG 669

  Fly   897 PIASDVTVIYGPFLAHTVRIFNTRTHLD--------AAIYVENDIDFEPPPKNRETELFMRFVTN 953
            .:.:|:...:..::.....|::..|.|.        ....:|......|...|||..|    .|:
Mouse   670 TLVTDIRQYFYRYITDQEYIYSIHTRLAHPSLAGELLCQRIEQQYRVGPLDLNREAIL----RTS 730

  Fly   954 IDNIAQAPMQRDPLKEPVDAATMPELPVFYSDQNGFQYHERIKVP-----AIGIEGNYFPITSGA 1013
            .|..:|                    .|.|||.||:|...|   |     :..|..||:|:...|
Mouse   731 SDLNSQ--------------------QVLYSDNNGYQMQRR---PYKAFKSNPIPRNYYPMVQSA 772

  Fly  1014 FIQDSRLRLTLLTTHAQGAASYEPGQLEVMLDRR---TLYDDYRGMGEGVVDSRLTRHKFWLLV- 1074
            ||:|.:.||.||.....|.:|...||:||||.||   .|..|.: ....:.|:.:.....||::
Mouse   773 FIEDDKSRLVLLAERPHGVSSQGNGQVEVMLHRRLWNNLAWDLK-YNLTLNDTSIVHPVLWLMLG 836

  Fly  1075 -----------------------------EDLP-GGQH----VTQPPS--YKVLS--------QQ 1095
                                         |:.| .|.|    ||.||:  .::||        ..
Mouse   837 PKSTMTALHPRSGVALQHGPVVLLKELADEETPVHGPHNPWPVTLPPNLHLQILSVPGWTYSRSH 901

  Fly  1096 AQQLANALRYPPNLYFVSNLEQPE--LAAALLPLVRLLPKGPLPCDVHLTTLRTLSDPELQLFPS 1158
            ||.|.|..|..|        |:|:  |...||.|..|...|              .||.|....:
Mouse   902 AQHLRNLQRGHP--------EKPQANLQRVLLRLRHLYEAG--------------EDPVLSRPAT 944

  Fly  1159 ASALLVLHRQGFDCSVSAGRELSMEAICPLSSKGLGNVQLGRLSLHTIEATSLTGTEQKSSRESY 1223
            ....:||                         :|||:|.       .:|..|||||......:.:
Mouse   945 VDLKVVL-------------------------RGLGSVV-------AVEERSLTGTWDVQMLQRW 977

  Fly  1224 HIRSLAE-----------------ISLEPMELRTFNLTFR 1246
            |..:..:                 |::.|.|:|||.:.|:
Mouse   978 HWSTKTDHLKGHPTSPPRPPGGSIITVYPKEIRTFFIKFQ 1017

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Man-IIb	NP_001262614.1	PLN02701	148..1246	CDD:178304	282/1208 (23%)
		GH38N_AMII_GMII_SfManIII_like	167..514	CDD:212120	104/369 (28%)
		Alpha-mann_mid	508..596	CDD:286360	26/97 (27%)
		Glyco_hydro_38C	813..1241	CDD:285047	111/517 (21%)
Man2b2	NP_032576.2	GH38N_AMII_Epman_like	27..352	CDD:212122	98/357 (27%)
		Alpha-mann_mid	358..439	CDD:214875	25/95 (26%)
		Glyco_hydro_38C	491..1012	CDD:285047	140/660 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1959
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810