Protein Alignment alpha-Man-IIb and Man2b1

DIOPT Version :10

• Sequence 1: NP_650494.2
• Gene: alpha-Man-IIb / 41913
• FlyBaseID: FBgn0026616
• Length: 1249
• Species: Drosophila melanogaster
• Sequence 2: NP_001411770.1
• Gene: Man2b1 / 17159
• MGIID: 107286
• Length: 1024
• Species: Mus musculus
• Alignment Length: 1195
• Identity: 282/1195 - (23%)
• Similarity: 472/1195 - (39%)
• Gaps: 351/1195 - (29%)

  Fly   163 KQRPP-----LKIIVVPHSHNDPGWLKTFTNYF-------------------QSDSRQILNLLVT 203
            |..||     |.:.::||:|:|.|||||...|:                   .:..:.||:.:|:
Mouse    53 KTCPPTKPGMLNVHLLPHTHDDVGWLKTVDQYYYGMDLDFLNFMPTVLSDVQHASVQYILDSVVS 117

  Fly   204 KMQEYTDMTFIWSEISFLQLWWDQAHPTKQRALKRLIDAGRIEITTGGWVMTDEANVHIYPMLDQ 268
            .:.|.....||:.|::|...||.|.....|.|::.|:..||:|...|||||.|||..|...::||
Mouse   118 SLLEKPTRRFIYVEMAFFSRWWKQQTSATQDAVRNLVRQGRLEFVNGGWVMNDEAATHYGAIVDQ 182

  Fly   269 LIEGHQWLKNNL--NVTPKVGWSIDPFGHGSTVPYLLSGANFEGTIIQRIHYAWKQWFARQQSGD 331
            :..|.::|::..  :..|:|.|.||||||......|.:...|:|..:.||.|..|    ..:...
Mouse   183 MTLGLRFLQDTFGSDGLPRVAWHIDPFGHSREQASLFAQMGFDGFFLGRIDYQDK----LNRKKK 243

  Fly   332 FIWKPYWRSRKDKDSEAGSLLTHNMPFDIYSIKGSCGPHPFICLNFDFRKIPGEYTEYSVKAQFI 396
            ...:..||:....:..|..|.|..:|       .:..|..::|.:.                 ..
Mouse   244 LRMEELWRASDSLEPPAADLFTGVLP-------NNYNPPKYLCWDV-----------------LC 284

  Fly   397 TD----DNLES---KAQLLLEQYARTAS----LFPHNVALIPVGDDFRYNKDREVDQQYQNYKKL 450
            ||    ||..|   .|:.|:..:.:.||    .:..|..::.:|.||.|   ...:..::|..||
Mouse   285 TDPPVVDNPRSPEFNAKTLVNYFLKLASSQKGFYRTNHTVMTMGSDFHY---ENANMWFKNMDKL 346

  Fly   451 IDHIMANRRLYNAD--------IRFGTPSDY-FEAIKERMKDHTPGFPTFKGDFFVYSDIFSEGR 506
            |       ||.||.        :.:.||:.| :|..|..:.     :...:.|||.|:|    |.
Mouse   347 I-------RLVNAQQVNGSLVHVLYSTPTCYLWELNKANLT-----WTVKEDDFFPYAD----GP 395

  Fly   507 PAYWSGYFTTRPFYKLLSSELEHQLRSAEIVFTLAYNTARQAKRENAIKIYEKNYELIINARRNL 571
            ..:|:|||::||..|...              .|:||..:...:          .|.::....|:
Mouse   396 HMFWTGYFSSRPALKRYE--------------RLSYNFLQVCNQ----------LEALVGPEANV 436

  Fly   572 G---------------LFQHHDAITGTSKAAVMRDYAMRLFESTQNMVKMQESCLELLLQKGQPR 621
            |               :.|||||::||::..|:.|||.:|...       ...| |:|:.....|
Mouse   437 GPYGSGDSAPLQEAMAVLQHHDAVSGTARQNVVNDYARQLAAG-------WGPC-EVLVSNALAR 493

  Fly   622 HHGFLLSEFERDNFNKLPRKMPIQMANGDESTPTVPAGEGGAGGSSSSGSVGSFVLYNSLAQKRL 686
                 ||.: :.||: ..|::.|.:.         |.        |.:.......|||.|.:|..
Mouse   494 -----LSHY-KQNFS-FCRELNISIC---------PV--------SQTSERFQVTLYNPLGRKVD 534

  Fly   687 EVVTLRVQHPN--VKIVNDKGVELNHIQINPVWNITDTYEQGLGTSVSGTVGRIRTSTRQFEVMF 749
            ::|.|.|...|  ||..:||.:..|.:.:...:  ::||                    |:|::|
Mouse   535 QMVRLPVYEGNFIVKDPHDKNISSNVVMVPSYY--SETY--------------------QWELLF 577

  Fly   750 VAELEPLSLSTYRV-QVDEVNFK-RNIATIYCDDCTESQPASVSPPEEIESSPTSVFEARGKPAG 812
            .|.:..|..|||.| ::.::|.: .|:               :|.|.:.:|....|
Mouse   578 PASVPALGFSTYSVAKMSDLNHQAHNL---------------LSRPRKHKSHHVLV--------- 618

  Fly   813 DIQLENPHMRLLFDEKSGFLKTITRKNQKKELLKPLQ-----CNIKFAAYRSAQFHSGAYLFKTD 872
               :||.:||..||..:|.|..|  :|.::.|..|:.     .|.......|:| .||||:|:.:
Mouse   619 ---IENKYMRATFDSGTGLLMKI--ENLEQNLSLPVSQGFFWYNASVGDEESSQ-ASGAYIFRPN 677

  Fly   873 PEQSEAEKEV-LEGYTDMRIIITSGPIASDVTVIYGPFLAHTVRIFNTRTHLDAAIYVENDIDFE 936
                 ..|.: :..:..:.::.|:  :..:|...:..:.:..:|::..:.||:    :|..:...
Mouse   678 -----VGKPIPVSRWAQISLVKTA--LVQEVHQNFSAWCSQVIRLYKGQRHLE----LEWTVGPI 731

  Fly   937 PPPKNRETELFMRFVTNIDNIAQAPMQRDPLKEPVDAATMPELPVFYSDQNGFQYHER------- 994
            |...:...|:..||.|.:....|                      |::|.||.:..:|
Mouse   732 PVRDDWGKEVISRFDTPMKTKGQ----------------------FFTDSNGREILKRRDDYRPT 774

  Fly   995 ----IKVPAIGIEGNYFPITSGAFIQDSRLRLTLLTTHAQGAASYEPGQLEVMLDRRTLYDDYRG 1055
                ...|   :.|||:|:.:..:|.|.:::||:||..:||.:|.:.|.||:|:.||.|.||.||
Mouse   775 WTLNQTEP---VAGNYYPVNTRIYITDGQMQLTVLTDRSQGGSSLQDGSLELMVHRRLLVDDDRG 836

  Fly  1056 MGEGVVDSRLTRHKFWLLVEDLPGGQHVTQPPS-------YKVLSQQ---AQQLANAL------- 1103
            :.|.::::.         ..|...|:|:....|       :::|::|   |.|:..:|
Mouse   837 VSEPLLETD---------TGDKVRGRHLVLLSSVSDAAARHRLLAEQEVLAPQVVLSLGGSSPYH 892

  Fly  1104 -RYPPNLYFVSNLEQPELAAALLPLVRLLPKGPLPCDVHLTTLRTLSDPELQLFPSASALLVLHR 1167
             |..|...| |.|.|                 .||..|||.||.......|        ||.|..
Mouse   893 SRATPKTQF-SGLRQ-----------------ELPPQVHLLTLARWGPKML--------LLRLEH 931

  Fly  1168 QGFDCSVSAGRELSMEAICPLSSKGLGNVQ--LGRLSLHTIEATSLTGTE--QKSSR-------- 1220
            | |.....:.|.||    .|::.    |||  ....:::.::.|:|...:  .::||
Mouse   932 Q-FALKEDSDRNLS----SPVTL----NVQNLFQTFTINYLQETTLAANQPLSRASRLKWMTNTG 987

  Fly  1221 -ESYHIRSLAE---ISLEPMELRTF 1241
             .||...|..:   ::|:|||:|||
Mouse   988 PTSYPEPSKLDPTSVTLKPMEIRTF 1012

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Man-IIb	NP_650494.2	PLN02701	148..1246	CDD:178304	282/1195 (24%)
Man2b1	NP_001411770.1	None