DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Man-IIb and Man2a1

DIOPT Version :9

Sequence 1:	NP_001262614.1	Gene:	alpha-Man-IIb / 41913	FlyBaseID:	FBgn0026616	Length:	1249	Species:	Drosophila melanogaster
Sequence 2:	NP_032575.2	Gene:	Man2a1 / 17158	MGIID:	104669	Length:	1150	Species:	Mus musculus

Alignment Length:	1234	Identity:	403/1234 - (32%)
Similarity:	623/1234 - (50%)	Gaps:	211/1234 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 RGSPLSGLTGFSVDGGSSSIIHQQKQQLVIASNQKK---SSETKSAQTSVSPEEQSEEQYTNSNW 112
            ||||         ...|...||....||.:.::.:.   :|::.|....|...:
Mouse    88 RGSP---------GNASQGSIHLHSPQLALQADPRDCLFASQSGSQPRDVQMLD----------- 132

  Fly   113 GDKCYELIQSNTNITASEEHSKFDFQPEWMRSKEYWDRGFEERFDAQKKDKQRPPLKIIVVPHSH 177
               .|:||             .|| .|:    ...|.:||:.:::|.:.|.:  ||::.||||||
Mouse   133 ---VYDLI-------------PFD-NPD----GGVWKQGFDIKYEADEWDHE--PLQVFVVPHSH 174

  Fly   178 NDPGWLKTFTNYFQSDSRQILNLLVTKMQEYTDMTFIWSEISFLQLWWDQAHPTKQRALKRLIDA 242
            |||||||||.:||:..::.|.|.:|.|::|.:...|:|||||:|..|||.....|:.|:|.|:..
Mouse   175 NDPGWLKTFNDYFRDKTQYIFNNMVLKLKEDSSRKFMWSEISYLAKWWDIIDIPKKEAVKSLLQN 239

  Fly   243 GRIEITTGGWVMTDEANVHIYPMLDQLIEGHQWLKNNLNVTPKVGWSIDPFGHGSTVPYLLSGAN 307
            |::||.||||||.|||..|.:.::||||||||||:.||.|.|:.||:||||||..|:.|||..|.
Mouse   240 GQLEIVTGGWVMPDEATPHYFALIDQLIEGHQWLEKNLGVKPRSGWAIDPFGHSPTMAYLLKRAG 304

  Fly   308 FEGTIIQRIHYAWKQWFARQQSGDFIWKPYWRSRKDKDSEAGSLLTHNMPFDIYSIKGSCGPHPF 372
            |...:|||:|||.|:.|:..::.:|.|:..|    |..| |..:|.|.|||..|.|..:|||.|.
Mouse   305 FSHMLIQRVHYAIKKHFSLHKTLEFFWRQNW----DLGS-ATDILCHMMPFYSYDIPHTCGPDPK 364

  Fly   373 ICLNFDFRKIP-GEY-TEYSVKAQFITDDNLESKAQLLLEQYARTASLFPHNVALIPVGDDFRYN 435
            ||..|||:::| |.| ..:.|..:.|:..|::|:||:||:||.:.:.||...|.|.|:|||||::
Mouse   365 ICCQFDFKRLPGGRYGCPWGVPPEAISPGNVQSRAQMLLDQYRKKSKLFRTKVLLAPLGDDFRFS 429

  Fly   436 KDREVDQQYQNYKKLIDHIMANRRLYNADIRFGTPSDYFEAIKERM----KDHTPGFPTFKGDFF 496
            :..|.|.|.:||::|..::.:...| ...|:|||.||||:|:::.:    |.....||...||||
Mouse   430 EYTEWDLQCRNYEQLFSYMNSQPHL-KVKIQFGTLSDYFDALEKAVAAEKKSSQSVFPALSGDFF 493

  Fly   497 VYSDIFSEGRPAYWSGYFTTRPFYKLLSSELEHQLRSAEIVFTLAYNTARQAKRENAIKIYEKNY 561
            .|:|....    |||||||:|||||.:...:|.::|:|||::.||...|::.|....:.  ..:|
Mouse   494 TYADRDDH----YWSGYFTSRPFYKRMDRIMESRIRAAEILYQLALKQAQKYKINKFLS--SPHY 552

  Fly   562 ELIINARRNLGLFQHHDAITGTSKAAVMRDYAMRLFESTQNMVKMQESCLELLLQKGQPRHH--- 623
            ..:..|||||||||||||||||:|..|:.||..|||:|..::.|:......||:.|.:..:.
Mouse   553 TTLTEARRNLGLFQHHDAITGTAKDWVVVDYGTRLFQSLNSLEKIIGDSAFLLILKDKKLYQSDP 617

  Fly   624 --GFLLSEFERDNFNKLPRKMPIQMANGDESTPTVPAGEGGAGGSSSSGSVGSFVLYNSLAQKRL 686
              .||..:.::.:.:.||:|:.||:                     |:......|:||...|:|.
Mouse   618 SKAFLEMDTKQSSQDSLPQKIIIQL---------------------SAQEPRYLVVYNPFEQERH 661

  Fly   687 EVVTLRVQHPNVKIVNDKGVELNHIQINPVWNITDTYEQGLGTSVSGTVGRIRTSTRQFEVMFVA 751
            .||::||....||:::|.|..: .:|::.|||...|..|.                 .:||.|:|
Mouse   662 SVVSIRVNSATVKVLSDSGKPV-EVQVSAVWNDMRTISQA-----------------AYEVSFLA 708

  Fly   752 ELEPLSLSTYRVQVDEVNFKRNIATIYCDDCTESQPASVSPPEEI-----ESSPTSVFEARGK-P 810
            .:.||.|..:::                   .|||.:|....:.:     ..:...:|..:.. .
Mouse   709 HIPPLGLKVFKI-------------------LESQSSSSHLADYVLYNNDGLAENGIFHVKNMVD 754

  Fly   811 AGD-IQLENPHMRLLFDEKSGFLKTITRKNQKKELLKPLQCNIKFAAY--RSAQFHSGAYLFKTD 872
            ||| |.:|||.:.:.|| :||.::.:.||...::    .:..::|..|  .:.:..||||||..|
Mouse   755 AGDAITIENPFLAIWFD-RSGLMEKVRRKEDSRQ----HELKVQFLWYGTTNKRDKSGAYLFLPD 814

  Fly   873 PEQSEAEKEVLEGYTDMR---IIITSGPIASDVTVIYGPFLAHTVRIFNTRTHLDAAIYVENDID 934
            .:.        :.|..:|   :.:|.|.|.|||| .:...:.|.||::|.:.....::.|.|.::
Mouse   815 GQG--------QPYVSLRPPFVRVTRGRIYSDVT-CFLEHVTHKVRLYNIQGIEGQSMEVSNIVN 870

  Fly   935 FEPPPKN-RETELFMRFVTNIDNIAQAPMQRDPLKEPVDAATMPELPVFYSDQNGFQYHERIKVP 998
            .    :| ...|:.||..:.|:|..:                      :|:|.||:|...|..:.
Mouse   871 I----RNVHNREIVMRISSKINNQNR----------------------YYTDLNGYQIQPRRTMS 909

  Fly   999 AIGIEGNYFPITSGAFIQDSRLRLTLLTTHAQGAASYEPGQLEVMLDRRTLYDDYRGMGEGVVDS 1063
            .:.::.|.:|:.:.|:|||:..|||||:..:.||:|...||:||.:|||.:.||.||:|:||.|:
Mouse   910 KLPLQANVYPMCTMAYIQDAEHRLTLLSAQSLGASSMASGQIEVFMDRRLMQDDNRGLGQGVHDN 974

  Fly  1064 RLTRHKFWLLVEDLPG---GQHVTQPPSY-KVLSQQAQQLANALRYPPNLYFVSNLEQPELAAAL 1124
            ::|.:.|.:|:|....   .:....|.|| .:||.......|    .|.|..|.:.:.|..|..|
Mouse   975 KITANLFRILLEKRSAVNMEEEKKSPVSYPSLLSHMTSSFLN----HPFLPMVLSGQLPSPAFEL 1035

  Fly  1125 LPLVRLLPKGPLPCDVHLTTLRTLSDPELQLFPSASALLVLHRQGFDCSVSAGRELSMEAICPLS 1189
            |....|| :..||||:||..|||:.. ::....|..|.|:|||:||||.              .|
Mouse  1036 LSEFPLL-QSSLPCDIHLVNLRTIQS-KMGKGYSDEAALILHRKGFDCQ--------------FS 1084

  Fly  1190 SKGLG---NVQLGRLSL----HTIEATSLTGTEQKSSRESYHIRSLAEISLEPMELRTFNLTFR 1246
            |:|:|   :...|::|:    :.....||..:...........::::|:||.|||:.||.:..|
Mouse  1085 SRGIGLPCSTTQGKMSVLKLFNKFAVESLVPSSLSLMHSPPDAQNMSEVSLSPMEISTFRIRLR 1148

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Man-IIb	NP_001262614.1	PLN02701	148..1246	CDD:178304	384/1132 (34%)
		GH38N_AMII_GMII_SfManIII_like	167..514	CDD:212120	161/352 (46%)
		Alpha-mann_mid	508..596	CDD:286360	43/87 (49%)
		Glyco_hydro_38C	813..1241	CDD:285047	128/445 (29%)
Man2a1	NP_032575.2	PLN02701	127..1148	CDD:178304	391/1184 (33%)
		GH38N_Man2A1	164..507	CDD:212131	161/352 (46%)
		Alpha-mann_mid	502..587	CDD:214875	43/86 (50%)
		Glyco_hydro_38C	757..1143	CDD:285047	128/445 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838008
Domainoid	1	1.000	98	1.000	Domainoid score	I7164
eggNOG	1	0.900	-	-		E1_KOG1959
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4542
OMA	1	1.010	-	-		QHG55783
OrthoDB	1	1.010	-	-		D1101882at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102728
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.570