Protein Alignment alpha-Man-IIb and Man2a2

DIOPT Version :9

• Sequence 1: NP_001262614.1
• Gene: alpha-Man-IIb / 41913
• FlyBaseID: FBgn0026616
• Length: 1249
• Species: Drosophila melanogaster
• Sequence 2: NP_766491.2
• Gene: Man2a2 / 140481
• MGIID: 2150656
• Length: 1152
• Species: Mus musculus
• Alignment Length: 1196
• Identity: 411/1196 - (34%)
• Similarity: 621/1196 - (51%)
• Gaps: 190/1196 - (15%)

  Fly    89 ETKSAQTSVSPEEQSEEQYTNSNWGDKCYELIQSNTNITASEEHSKFDFQPEWMRSKE--YWDRG 151
            |.:.:..||||::.   |:.....|.| .||    ..:|.||: ..||       :.|  .|.:|
Mouse   103 EPRPSFFSVSPQDC---QFALGGRGQK-PEL----QMLTVSED-LPFD-------NVEGGVWRQG 151

  Fly   152 FEERFDAQKKDKQRPPLKIIVVPHSHNDPGWLKTFTNYFQSDSRQILNLLVTKMQEYTDMTFIWS 216
            |:..:.....|.:  .|::.|||||||||||:|||..|:...::.|||.:|:|:||.....|:|:
Mouse   152 FDISYSPNDWDTE--DLQVFVVPHSHNDPGWIKTFDKYYTEQTQHILNSMVSKLQEDPRRRFLWA 214

  Fly   217 EISFLQLWWDQAHPTKQRALKRLIDAGRIEITTGGWVMTDEANVHIYPMLDQLIEGHQWLKNNLN 281
            |:||...|||.....|:.|::||:..|::||.||||||.||||.|.:.::||||||||||:.||.
Mouse   215 EVSFFAKWWDNISAQKRAAVRRLVGNGQLEIATGGWVMPDEANSHYFALVDQLIEGHQWLERNLG 279

  Fly   282 VTPKVGWSIDPFGHGSTVPYLLSGANFEGTIIQRIHYAWKQWFARQQSGDFIWKPYWRSRKDKDS 346
            .||:.||::|||||.||:||||..||....:|||:|||.|:.||...|.:|:|:..|    |.||
Mouse   280 ATPRSGWAVDPFGHSSTMPYLLRRANLTSMLIQRVHYAIKKHFAATHSLEFMWRQMW----DSDS 340

  Fly   347 EAGSLLTHNMPFDIYSIKGSCGPHPFICLNFDFRKIPGEYTE--YSVKAQFITDDNLESKAQLLL 409
            .. .:..|.|||..|.:..:|||.|.||..|||:::||....  :.|..:.||:.|:..:|.|||
Mouse   341 ST-DIFCHMMPFYSYDVPHTCGPDPKICCQFDFKRLPGGRINCPWKVPPRAITEANVADRAALLL 404

  Fly   410 EQYARTASLFPHNVALIPVGDDFRYNKDREVDQQYQNYKKLIDHIMANRRLYNADIRFGTPSDYF 474
            :||.:.:.||..||.|:|:||||||:|.:|.|.|:.||::|.| .:.::..::...:|||.|:||
Mouse   405 DQYRKKSRLFRSNVLLVPLGDDFRYDKPQEWDAQFFNYQRLFD-FLNSKPEFHVQAQFGTLSEYF 468

  Fly   475 EAIKERM----KDHTPGFPTFKGDFFVYSDIFSEGRPAYWSGYFTTRPFYKLLSSELEHQLRSAE 535
            :|:.:|.    ....||||...||||.|:|    ....||:||:|:|||||.|...||..||.||
Mouse   469 DALYKRTGVEPGARPPGFPVLSGDFFSYAD----REDHYWTGYYTSRPFYKSLDRVLEAHLRGAE 529

  Fly   536 IVFTLAYNTARQAKRENAIKIYEKNYELIINARRNLGLFQHHDAITGTSKAAVMRDYAMRLFEST 600
            |:::||...||::.......:  .::.|:..|||.|||||||||||||:|.||:.||.:||..|.
Mouse   530 ILYSLALAHARRSGLAGQYPL--SDFALLTEARRTLGLFQHHDAITGTAKEAVVVDYGVRLLRSL 592

  Fly   601 QNMVKMQESCLELLL---------QKGQPRHHGFLLSEFERDNFNKLPRKMPIQMANGDESTPTV 656
            .::.::..:....|:         ..|.|    ||..:..|.:.:.||.:..|::    :|:|..
Mouse   593 VSLKQVIINAAHYLVLGDQETYSFDPGTP----FLQMDDSRVSHDALPERTVIRL----DSSPRF 649

  Fly   657 PAGEGGAGGSSSSGSVGSFVLYNSLAQKRLEVVTLRVQHPNVKIVNDKGVELNHIQINPVWN--- 718
                              .|::|.|.|:||.||:|.|..|.|::::::|..|: :||:..|:
Mouse   650 ------------------VVVFNPLEQERLSVVSLLVNSPRVRVLSEEGQPLS-VQISVHWSSAT 695

  Fly   719 --ITDTYEQGLGTSVSGTVGRIRTSTRQFEVMFVAELEPLSLSTYRVQVDEVNFKRNIATIYCDD 781
              :.|.|:..:...:.| :|           :.|.:|:|.....|.:|        :...:|.:.
Mouse   696 DMVPDVYQVSVPVRLPG-LG-----------LGVLQLQPDLDGPYTLQ--------SSVRVYLNG 740

  Fly   782 CTESQPASVSPPEEIESSPTSVFEAR--GKPAGDIQLENPHMRLLFDEKSGFLKTITRKNQKKEL 844
            .            ::..|..|.|..|  ...|.|..:.|.:|::.|...:|.||:|.|.::::|
Mouse   741 V------------KLSVSRQSAFPVRVVDSGASDFAISNRYMQVWFSGLTGLLKSIRRVDEEQE- 792

  Fly   845 LKPLQCNIKFAAY--RSAQFHSGAYLFKTDPEQSEAEKEVLEGYTDMRIIITSGPIASDVTVIYG 907
               .|..::|..|  |:::..||||||..|   |||:..|.:....:|  :|.||..|:|.|.|.
Mouse   793 ---QQMELEFLVYGTRTSKDKSGAYLFLPD---SEAKPYVPKKPPVLR--VTEGPFFSEVAVYYE 849

  Fly   908 PFLAHTVRIFNTRTHLDAAIYVENDIDFEPPPKNR-ETELFMRFVTNIDNIAQAPMQRDPLKEPV 971
            .| ...:|::|    |.....:..|:.|:...::. ..||.:|..|:||:..
Mouse   850 HF-HQVIRLYN----LPGVEGLSLDMSFQVDIRDYVNKELALRIHTDIDSQG------------- 896

  Fly   972 DAATMPELPVFYSDQNGFQYHERIKVPAIGIEGNYFPITSGAFIQDSRLRLTLLTTHAQGAASYE 1036
                     .|::|.||||...|..:..:.::.|::|:...|:||||:.||||.|..|.|.:|..
Mouse   897 ---------TFFTDLNGFQIQPRQYLKKLPLQANFYPMPVMAYIQDSQRRLTLHTAQALGVSSLG 952

  Fly  1037 PGQLEVMLDRRTLYDDYRGMGEGVVDSRLTRHKFWLLVEDLPGGQHVTQPPSYKVLSQQAQQLAN 1101
            .|||||:||||.:.||.||:|:|:.|:::|.::|.||:|     :..|..|......:::....:
Mouse   953 NGQLEVILDRRLMQDDNRGLGQGLKDNKITCNRFRLLLE-----RRTTMSPEVHQEQERSTSYPS 1012

  Fly  1102 ALRYPPNLYFVSNLEQPELAAALLPLVR----------LLP-KGPLPCDVHLTTLRTLSDPELQL 1155
            .|.:..::|    |..|.|   :||:.:          ..| ..|||||.||..||.|  |....
Mouse  1013 LLSHLTSMY----LSTPPL---VLPVAKRQGTSPALRSFHPLASPLPCDFHLLNLRML--PAEDT 1068

  Fly  1156 FPSASALLVLHRQGFDCSVSAGRELSMEAICPLSSKGLGNVQLGRLSLHTIEATSLTGTEQKSSR 1220
            .|:..:.|:|||:||||.:.| :.|...  |..|.   |.:.||.| .|.::.|.|..|   |..
Mouse  1069 LPATDSALILHRKGFDCGLEA-KNLGFN--CTTSQ---GKLALGSL-FHGLDVTFLQPT---SLT 1123

  Fly  1221 ESYHIRS---LAEISLEPMELRTFNL 1243
            ..|.:.|   ..:|||||||:.||.|
Mouse  1124 LLYPLASPSNSTDISLEPMEISTFRL 1149

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Man-IIb	NP_001262614.1	PLN02701	148..1246	CDD:178304	395/1135 (35%)
		GH38N_AMII_GMII_SfManIII_like	167..514	CDD:212120	161/352 (46%)
		Alpha-mann_mid	508..596	CDD:286360	44/87 (51%)
		Glyco_hydro_38C	813..1241	CDD:285047	140/444 (32%)
Man2a2	NP_766491.2	PLN02701	140..1151	CDD:178304	398/1150 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838007
Domainoid	1	1.000	98	1.000	Domainoid score	I7164
eggNOG	1	0.900	-	-		E1_KOG1959
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55783
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102728
Panther	1	1.100	-	-	LDO	PTHR11607
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.710