Protein Alignment alpha-Man-IIb and man2b2

DIOPT Version :9

• Sequence 1: NP_001262614.1
• Gene: alpha-Man-IIb / 41913
• FlyBaseID: FBgn0026616
• Length: 1249
• Species: Drosophila melanogaster
• Sequence 2: NP_001106515.1
• Gene: man2b2 / 100127706
• XenbaseID: XB-GENE-1006292
• Length: 990
• Species: Xenopus tropicalis
• Alignment Length: 1178
• Identity: 266/1178 - (22%)
• Similarity: 438/1178 - (37%)
• Gaps: 306/1178 - (25%)

  Fly   167 PLKIIVVPHSHNDPGWLKTFTNYFQSDSRQILNLLVTKMQEYTDMTFIWSEISFLQLWWDQ-AHP 230
            |::..|:||||.|.||:.|......:.:..:...:|.::.......||..|..|.:|||.. |..
 Frog    21 PIQAFVIPHSHMDVGWVYTVQESMHAYAANVYTTVVEELMRGDRRRFIVVEQEFFRLWWKLFAGN 85

  Fly   231 TKQRALKRLIDAGRIEITTGGWVMTDEANVHIYPMLDQLIEGHQWLKNNLNVTPKVGWSIDPFGH 295
            .:::.:.:|:..||:|...||.||.|||...|...:.||.|||.::.....|.|:..|.:||||.
 Frog    86 VEKQQVHQLMREGRLEFVIGGQVMHDEALTTIDDQILQLTEGHGFIYETFGVRPRFSWHVDPFGA 150

  Fly   296 GSTVPYLLSGANFEGTIIQRIHYAWKQWFARQQSG---DFIWK--PYWRSRKDKDSEAGSLLTHN 355
            .:..|.|.:.|.|.|.:|.||.|..|   |..|:|   .|||:  |   |..||.    .:.||.
 Frog   151 SAASPTLFAMAGFNGHLISRIDYDTK---ADMQNGKELQFIWRASP---SLSDKQ----EIFTHV 205

  Fly   356 MPFDIYSIKGSCGPH--PF----------ICLNFDFRKIPGEYTEYSVKAQFITDDNLESKAQLL 408
            |  |.||.   |.|.  ||          |.:..|..| .|.|...|:.   :|.|.:...|:.:
 Frog   206 M--DQYSY---CTPSYIPFSDRSGFYWNGIAVFPDPPK-DGMYPNMSLP---VTADTIHPYAETM 261

  Fly   409 LEQYARTASLFPHNVALIPVGDDFRYNKDREVDQQYQNYKKLIDHIMANRRLYNADIRFGTPSDY 473
            ::.....|:.|..:..|.|.|.|.::   .....|:.|...|:|:|..:.. :...:::.|..||
 Frog   262 VKNIKERAAWFRSSDVLWPWGCDKQF---FNASVQFNNMDLLLDYINKHTE-FGVTVQYSTLGDY 322

  Fly   474 FEAIKERMKDHTPGFPTFKG--DFFVYSDIFSEGRPAYWSGYFTTRPFYKLLSSELEHQLRSAEI 536
            |:.:..|  :.|.|   .:|  ||..||...|:.    |:|::|:|...|.::......|.:||.
 Frog   323 FKNLYNR--NLTWG---LRGSQDFLPYSSDSSQA----WTGFYTSRNVLKGVARRASSLLYAAES 378

  Fly   537 VFT---LAYNTARQAKRENAIKIYEKNYELIINARRNLGLFQHHDAITGTSKAAVMRDYAMRLFE 598
            .|.   |.:.|.      :..|::.  .|.:.:.|..:...||||.||||....|...|...|.:
 Frog   379 AFAQHLLKHPTG------SVEKVWA--MEQLRSLRWAVSEVQHHDGITGTESPKVRDMYIANLLQ 435

  Fly   599 STQNMVKMQESCLELLLQKGQPRHHGFLLSEFERDNFNKLPRKMPIQMANGDESTPTVPAGEGGA 663
            ....:.|                    |::....|.:
 Frog   436 GAAGVRK--------------------LMAAIVMDLY---------------------------- 452

  Fly   664 GGSSSSGSVG----SFVLYNSLAQKRLEVVTLRVQHPNVKIVNDKGVELNHIQINPVWNITDTYE 724
              ||.:.|.|    :..:||.||                                  |::|....
 Frog   453 --SSQANSCGNGYINITVYNPLA----------------------------------WDVTTFVL 481

  Fly   725 QGLGTSVSGTV--------GRIRTST---RQFEVMFVAELEPLSLSTYRVQVDEVNFKRNIATIY 778
            ..:..||||..        .:|:.:|   ..|::..:..|:.||...|.:::..
 Frog   482 VPMNNSVSGVYDKFGQPVPAQIQNATEPSNAFDLHILVTLKGLSYGRYSIKLGS----------- 535

  Fly   779 CDDCTESQPASVSPPEEIESSPTSVFEARGKPAGDIQLENPHMR----LLFDEKSGFLKTITRKN 839
            ||...:.....        ...|.|.:.:...|....|..|.|.    ::.|:.:..|.:||
 Frog   536 CDAANDRLVTG--------RKITFVRQPKRNKAKRQNLVTPIMNDCYTVVIDQNTNLLHSIT--- 589

  Fly   840 QKKELLKPLQCNIKFAAYRS-AQFHSGA----YLF-KTDPEQSEAEKEVLEGYTDMRIIITSGPI 898
             .:|..:.:|...:|..|.| .....|.    ||| .|.|        .:..|..:.:.|.:|.:
 Frog   590 -ARESNQTVQVTQEFLEYHSNGDISKGPISDNYLFTSTGP--------AISAYKAVGLEIIAGKL 645

  Fly   899 ASDV-TVIYGPFLAHTV------RIFNTRTHLDAAI---YVENDIDFEPPPKNRETELFMRFVTN 953
            .::: ...|....|.|.      ||:|.....|.::   ::|......|...|||:  .:|..|:
 Frog   646 VTEIRQYFYSNITAQTYLYAVYSRIYNVPEGYDKSLVCHHIEQSYRVGPMDLNRES--IIRTSTD 708

  Fly   954 IDNIAQAPMQRDPLKEPVDAATMPELPVFYSDQNGFQYHER--IKVPAIGIEGNYFPITSGAFIQ 1016
                    ::.|.|              .|:|.||:|...|  .......:..||:|:...|:|:
 Frog   709 --------LRTDRL--------------IYTDNNGYQMQRRQFKNYDTNTVARNYYPMVRTAYIE 751

  Fly  1017 DSRLRLTLLTTHAQGAASYEPGQLEVMLDRRTLYDDYR---GMGEGVVDSRLTRHKFWLLVEDLP 1078
            |:..||..|:..|.|.:|.:.|::|:||.|| |:::..   .....:.|:.:.|...||::
 Frog   752 DNSTRLVFLSERAHGVSSQDNGEVEIMLHRR-LWNNLEWDLNYNLTLNDTSVVRPTIWLML---- 811

  Fly  1079 GGQHVTQPPSYKVLSQQAQQLANALRYPPNLYFV--SNLEQPELAAALLPLVRLLPKGPLPCDVH 1141
             |........|       |:|..||.:.|.:.:.  :..|:.......||:.       ||.::|
 Frog   812 -GSRALAGALY-------QRLGMALEHRPLVIYSLHTGQEKRSYKTTDLPIT-------LPDNIH 861

  Fly  1142 LTTLR--------------------TLSDPELQLFPSASALLVLHRQGFDCSVSAGRELSMEAIC 1186
            |..|.                    .:.|...........|..|:....|..:|....::::::.
 Frog   862 LQILSIPGWFYSSRHHEHMQDIHTGNIRDNVADFHRVLLRLQHLYETNEDPVLSKPVTINLQSLL 926

  Fly  1187 PLSSKGLGNVQL-------GRLSLHTIE----ATSLTGTEQKSSRESYHIRSLAE--ISLEPMEL 1238
                ||||.|.|       |...:||::    ..::.||:|:.     |....::  |:|.|.|:
 Frog   927 ----KGLGTVSLVEERSLTGTWDIHTLKRWKWKANIKGTDQRE-----HTLGTSDFTITLSPKEI 982

  Fly  1239 RTFNLTFR 1246
            ||..:.|:
 Frog   983 RTLFVYFQ 990

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Man-IIb	NP_001262614.1	PLN02701	148..1246	CDD:178304	265/1176 (23%)
		GH38N_AMII_GMII_SfManIII_like	167..514	CDD:212120	108/366 (30%)
		Alpha-mann_mid	508..596	CDD:286360	24/90 (27%)
		Glyco_hydro_38C	813..1241	CDD:285047	104/487 (21%)
man2b2	NP_001106515.1	GH38N_AMII_Epman_like	22..346	CDD:212122	103/351 (29%)
		Alpha-mann_mid	352..433	CDD:214875	24/88 (27%)
		Glyco_hydro_38C	567..985	CDD:285047	103/482 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910