DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9593 and TNC

DIOPT Version :9

Sequence 1:	NP_650493.2	Gene:	CG9593 / 41912	FlyBaseID:	FBgn0038365	Length:	382	Species:	Drosophila melanogaster
Sequence 2:	XP_016870167.1	Gene:	TNC / 3371	HGNCID:	5318	Length:	2384	Species:	Homo sapiens

Alignment Length:	224	Identity:	67/224 - (29%)
Similarity:	108/224 - (48%)	Gaps:	13/224 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   150 PAKSDCHE-LDEGVRVDGVYRFLVPERNEVQRDLYERYCAFATDGPAWTVIQSRGGSFDPHENFN 213
            |...||.: :..|....|:|...:   |..:.:..|.:|...:||..|.|...|...   .|||.
Human  2162 PFPKDCSQAMLNGDTTSGLYTIYL---NGDKAEALEVFCDMTSDGGGWIVFLRRKNG---RENFY 2220

  Fly   214 RSWDEYRAGFGNLSRDFWFGNEFAHKILYRDDHELRIELQEAGEPLDWAEYPLFWLDSESYNYQL 278
            ::|..|.||||:...:||.|.:..:||..:..:|||::|::.||.. :|.|..|.:......|:|
Human  2221 QNWKAYAAGFGDRREEFWLGLDNLNKITAQGQYELRVDLRDHGETA-FAVYDKFSVGDAKTRYKL 2284

  Fly   279 SVAGEFRGSLPDALEQHNRMDFSTYDRRRNHAKSADSTCGEDYGGGWWFDRCTQCNLNGEHGVHQ 343
            .|.| :.|:..|::..||...|||:|:   ...||.:.|...|.|.:|:..|.:.||.|.:|.:.
Human  2285 KVEG-YSGTAGDSMAYHNGRSFSTFDK---DTDSAITNCALSYKGAFWYRNCHRVNLMGRYGDNN 2345

  Fly   344 RASPAIIWMNWRTGTDKPKSSRMMIRPVN 372
            . |..:.|.:|:......:.:.|.:||.|
Human  2346 H-SQGVNWFHWKGHEHSIQFAEMKLRPSN 2373

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9593	NP_650493.2	FReD	150..371	CDD:238040	65/221 (29%)
TNC	XP_016870167.1	EGF_2	377..403	CDD:285248
		EGF_2	408..434	CDD:285248
		EGF_2	468..496	CDD:285248
		EGF_2	504..527	CDD:285248
		EGF_2	533..558	CDD:285248
		fn3	624..695	CDD:306538
		fn3	713..793	CDD:306538
		fn3	804..884	CDD:306538
		fn3	894..976	CDD:306538
		fn3	986..1064	CDD:306538
		fn3	1075..1154	CDD:306538
		fn3	1169..1241	CDD:306538
		fn3	1260..1327	CDD:306538
		fn3	1348..1427	CDD:306538
		fn3	1439..1508	CDD:306538
		fn3	1533..1605	CDD:306538
		fn3	1619..1691	CDD:306538
		fn3	1716..1788	CDD:306538
		fn3	1804..1883	CDD:306538
		fn3	1894..1973	CDD:306538
		fn3	1985..2055	CDD:306538
		fn3	2071..2143	CDD:306538
		Fibrinogen_C	2163..2372	CDD:278572	64/220 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2579
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810