DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG9593 and Angptl3

DIOPT Version :9

Sequence 1:NP_650493.2 Gene:CG9593 / 41912 FlyBaseID:FBgn0038365 Length:382 Species:Drosophila melanogaster
Sequence 2:NP_038941.1 Gene:Angptl3 / 30924 MGIID:1353627 Length:455 Species:Mus musculus


Alignment Length:392 Identity:116/392 - (29%)
Similarity:181/392 - (46%) Gaps:75/392 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 LGSTGSLNRIGNSDIGFKSLE-----ELVLIRKTLAAQALKLRGLEINLHRVLSKVVLLADAVVQ 76
            |..|.|..::.|.::...|:|     |.:|..||  |...|:|.||..|..     ::|:.|..|
Mouse    99 LRRTTSTLQVKNEEVKNMSVELNSKLESLLEEKT--ALQHKVRALEEQLTN-----LILSPAGAQ 156

  Fly    77 VPGRYSSKEDPLAVLSERLNLLLERLNQE-ERISTNLLELKEWSTKV----CQEPS--------- 127
            .....:|.:..:......:..||:.:.:: :::|...:::||...::    .||||         
Mouse   157 EHPEVTSLKSFVEQQDNSIRELLQSVEEQYKQLSQQHMQIKEIEKQLRKTGIQEPSENSLSSKSR 221

  Fly   128 -PSQTLPKELTEEKDEPKVDFYQPAKSDCHEL-DEGVRVDGVYRFLVPERNEVQRDLYERYCAFA 190
             |..|.|.:|.|.::..:.|.  ||  ||..: :.|....|||  .:..||.   ..:..||...
Mouse   222 APRTTPPLQLNETENTEQDDL--PA--DCSAVYNRGEHTSGVY--TIKPRNS---QGFNVYCDTQ 277

  Fly   191 TDGPAWTVIQSRGGSFDPHENFNRSWDEYRAGFGNLSRDFWFGNEFAHKILYRDDHELRIELQEA 255
            :..| ||:||.|.   |..::||.:|:.|..|||.|..:||.|.|..:.|:.:.::.||:|||:.
Mouse   278 SGSP-WTLIQHRK---DGSQDFNETWENYEKGFGRLDGEFWLGLEKIYAIVQQSNYILRLELQDW 338

  Fly   256 GEPLDWAEYPLFWLDSESYNYQLSVAGEFRGSLPDALEQHNRMDFSTYDRRRNHAKSADSTCGED 320
            .:...:.||. |.|.|...||.|.|| |..|::|.||.:|..:.|||:    ||.......|.|.
Mouse   339 KDSKHYVEYS-FHLGSHETNYTLHVA-EIAGNIPGALPEHTDLMFSTW----NHRAKGQLYCPES 397

  Fly   321 YGGGWWF-DRCTQCNLNGEH-------------GVHQRASPAIIWMNWRTGTDK---PKSSRMMI 368
            |.||||: |.|.:.||||::             |::           ||..:.|   .|||:||:
Mouse   398 YSGGWWWNDICGENNLNGKYNKPRTKSRPERRRGIY-----------WRPQSRKLYAIKSSKMML 451

  Fly   369 RP 370
            :|
Mouse   452 QP 453

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG9593NP_650493.2 FReD 150..371 CDD:238040 81/239 (34%)
Angptl3NP_038941.1 Sufficient to inhibit LIPG/EL phospholipase activity. /evidence=ECO:0000250|UniProtKB:Q9Y5C1 17..207 25/114 (22%)
Sufficient to inhibit LPL lipase activity. /evidence=ECO:0000250|UniProtKB:Q9Y5C1, ECO:0000269|PubMed:20581395 17..165 20/72 (28%)
Required for inhibition of LPL lipase activity. /evidence=ECO:0000250|UniProtKB:Q9Y5C1 32..56
SPEC <34..191 CDD:295325 22/98 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 202..242 9/39 (23%)
FReD 241..453 CDD:238040 81/241 (34%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2579
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR19143
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
43.870

Return to query results.
Submit another query.