DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9593 and tnxb

DIOPT Version :9

Sequence 1:	NP_650493.2	Gene:	CG9593 / 41912	FlyBaseID:	FBgn0038365	Length:	382	Species:	Drosophila melanogaster
Sequence 2:	XP_031747219.1	Gene:	tnxb / 100489649	XenbaseID:	XB-GENE-481849	Length:	2840	Species:	Xenopus tropicalis

Alignment Length:	464	Identity:	110/464 - (23%)
Similarity:	172/464 - (37%)	Gaps:	138/464 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 GSTGSLNRIGNSDIGFKSLEELVLIRKTLAAQALKLRGLE------------------INLHRVL 64
            |...|:|.:|:|    |||:.| .:........:.:||.|                  ::.|.|.
Frog  2395 GEPESVNVVGDS----KSLQRL-NVGTRYEVTVVSVRGFEESQPLTGYITTGGGGPHSLHAHDVT 2454

  Fly    65 SKVVLL-----------------ADAVV----QVPGRYSSKEDPLAVLSERLNLLLERLNQEERI 108
            .:..||                 |:.|:    :|||  ...|.|::    .||...|.....:.:
Frog  2455 EESALLRWEPEPGFVDRYVVTYRAENVLSVTHEVPG--DQTELPIS----GLNPHTEYYASVQSL 2513

  Fly   109 STNLLELKEWSTKVCQEPSPSQTLPKELTEEK-----DEPKV--DFYQ----------------- 149
            ..:.|.....::.:....:|.:.|..::|.:.     ..|:|  |.|:
Frog  2514 HGSKLSSPTSTSFITSADTPRELLASQITAQSALLTWKPPQVVPDGYRLVYQTHDGEIKELILLA 2578

  Fly   150 --------------PAKSDCHELDEGVR---------VDGVYRFLVPERNEVQRDLYER------ 185
                          |.|...|.| .|..         ..|..|:..|      ||.:|:
Frog  2579 NLSSFTLSHLTPSTPYKVQLHAL-RGASSSAPISTSFTTGRIRYPFP------RDCWEKHMNGDL 2636

  Fly   186 -------------------YCAFATDGPAWTVIQSRGGSFDPHENFNRSWDEYRAGFGNLSRDFW 231
                               ||...|||..|.|.|.|   .|...:|.|:|.:|:.|||||:.:||
Frog  2637 QSGVFTIYLGGSKDDPLLVYCDMETDGGGWIVFQRR---IDGRTDFWRNWRQYKEGFGNLTSEFW 2698

  Fly   232 FGNEFAHKILYRDDHELRIELQEAGEPLDWAEYPLFWLDSESYNYQLSVAGEFRGSLPDALEQHN 296
            .||...|::.....:|||::|: ||....:|.|..|.::.|..:::|.: |.:||:..|:|..||
Frog  2699 LGNIALHRLSSLAPYELRVDLR-AGAEAAYAVYEDFRVEGEDKHFRLRI-GAYRGNAGDSLSYHN 2761

  Fly   297 RMDFSTYDRRRNHAKSADSTCGEDYGGGWWFDRCTQCNLNGEHGVHQRASPAIIWMNWRTGTDKP 361
            .|.|||.||   .|:.....|...|.|.||:..|...||||.:| :.:....:.|..|:......
Frog  2762 NMIFSTRDR---DAEKRILPCSISYRGAWWYKNCHYANLNGMYG-NNKDHQGVNWHTWKGFEFSI 2822

  Fly   362 KSSRMMIRP 370
            ..:.|.:||
Frog  2823 PFTEMKMRP 2831

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9593	NP_650493.2	FReD	150..371	CDD:238040	76/255 (30%)
tnxb	XP_031747219.1	EGF_Tenascin	179..206	CDD:376143
		exchanger_TraA	<400..779	CDD:411343
		EGF_Tenascin	799..826	CDD:376143
		fn3	834..913	CDD:394996
		FN3	923..998	CDD:214495
		fn3	1790..1852	CDD:394996
		fn3	1881..1960	CDD:394996
		fn3	1972..2051	CDD:394996
		fn3	2064..2141	CDD:394996
		fn3	2170..2245	CDD:394996
		fn3	2267..2338	CDD:394996
		FN3	2356..2433	CDD:238020	12/42 (29%)
		fn3	2445..2522	CDD:394996	15/82 (18%)
		fn3	2531..2609	CDD:394996	12/78 (15%)
		FReD	2622..2831	CDD:238040	67/223 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910