DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nsl1 and Kansl1

DIOPT Version :9

Sequence 1:	NP_732069.3	Gene:	nsl1 / 41911	FlyBaseID:	FBgn0262527	Length:	1570	Species:	Drosophila melanogaster
Sequence 2:	NP_001359388.1	Gene:	Kansl1 / 76719	MGIID:	1923969	Length:	1099	Species:	Mus musculus

Alignment Length:	1501	Identity:	307/1501 - (20%)
Similarity:	482/1501 - (32%)	Gaps:	585/1501 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 NAKASNEPMGLSTAPTPHSTTSPNPSTDTAAASTSAVEHNNNDSNSTSAGNST----------SA 142
            :|.|....:....|| |.||.||..:            .||.::|...:.|.|          |.
Mouse    10 DAAAEAHHIRFKLAP-PSSTLSPGSA------------ENNGNANILISANGTKRKAIAAEDPSL 61

  Fly   143 D--NSSTPKDNSTAQ------LLADLT-------INFEETISAEICLRKTLPDVS---------L 183
            |  |:.|.:|....|      |.:|:|       :..:...|.:..| |:.|.:|         |
Mouse    62 DFRNNPTKEDLGKLQPLVASYLCSDVTSVPAKESLKLQGVFSKQTVL-KSHPLLSQSYELRAELL 125

  Fly   184 GKEPVPPASVLAVATSSTSAGSALSLSAVDEVTK--------IEIDNIEE--------RLSQLDG 232
            |::||...|:..:.|.:||..:||..:.|:.:.|        .:.||...        ..|.|.|
Mouse   126 GRQPVLEFSLENLRTMNTSGQTALPQAPVNGLAKKLTKSSTHSDHDNSSSLNGGKRSLTSSSLQG 190

  Fly   233 NATGRPEE--------HVAPPSVPVPVQEAPNTPTRPQAPPSAHLESPQPARTQQQSIQQMTPQS 289
            ...|.|:.        :...|...:.:|..........|..|:.....|||   .|...:::|.:
Mouse   191 GEVGGPDSGNLKGGMTNCTLPHRSLDIQHTTLYSNNSTANKSSVNSMDQPA---LQGSSRLSPST 252

  Fly   290 TTSSNNFLKDGAAGAVLEDQDIEEVLKALKTFDGGHVNPDTICEFFDEVWEEAAPAAPLPPAPPE 354
            .:|||           |.:..:|                              ...:||
Mouse   253 DSSSN-----------LTNVKLE------------------------------VKKSPL------ 270

  Fly   355 NVVDVPGAKPSCSGILVSGSNISQPNVIIKQEQRPWQESHAELEQQQHVISRRIEFLLRRMRKLQ 419
                        |.||.|..:.......:.:.|       |::|    :.:||::   :|::.:|
Mouse   271 ------------SSILFSALDSDTRITALLRRQ-------ADIE----IRARRLQ---KRLQVVQ 309

  Fly   420 ARAMCRHASEEVVGIMEWSARSSHKAPVPARSSTLTEQEATVLSIVSGRPSSTFWEEQNKHPLPA 484
            |:.:.||...::.|.:|                       |.||
Mouse   310 AKQVERHLQHQLGGFLE-----------------------TTLS--------------------- 330

  Fly   485 SQMSNVIRHIATAAKHQQICHSASGSSATLAPSSSWYNSCNSSALPMKRPRKNQLDASVATGATP 549
                                                           |.|....|.:......|.
Mouse   331 -----------------------------------------------KLPNLESLRSRSQLMLTR 348

  Fly   550 TAPAPGAVTSRQAAGTTGSATG-SNTPRADDIVPGYDTYVTNELTHVSGLLHTELREVQNAIDSD 613
            .|.|    ..|:||..:.::.| ||..::|.|....:.:.      .||:  ..||..:.|.|||
Mouse   349 KAEA----ALRKAASESATSEGLSNFLKSDSISEELERFT------ASGI--ANLRCSEQAFDSD 401

  Fly   614 ATESSSGGES--ADEMVTYNNNQQLSLPITRRAVWRYSRDRAAIALRWSWLCSQLTDLEMKIRQH 676
            .|:|||||||  .:|.:|..:.:|..:|:.||:.||::.|||||..||:||.:.::|||.:|||.
Mouse   402 VTDSSSGGESDIEEEELTRADPEQCHVPLKRRSEWRWAADRAAIVSRWNWLQAHVSDLEYRIRQQ 466

  Fly   677 SDLYMDLTQSKGEIQL-----------------------------------------------ES 694
            :|:|..:..:||.|.|                                               ||
Mouse   467 TDIYKQIRANKGLIVLGEAPFPDHTTDLLSLSSEVKTDHGRDKLIESVSQPSENHGILVSNITES 531

  Fly   695 TAKTSPSLAQPANGI---------KEEPG--------------------SDYLCSRARPLVLSEF 730
            .:..|....:|.||:         .:.||                    ||..|..||...:...
Mouse   532 LSTKSCGAPRPVNGVVNSLQPVLADQVPGDSSDAEEQLHKKQRLNLVSSSDGTCVAARTRPVLTC 596

  Fly   731 RKRKLFQTTNMHTISKKAARPSNIKCGCQWPQVPCTLCTGRTDPTAPRDLVETMMPQNRVALLDA 795
            :||:|.:.:::..:|||..|  |::.||. ....|.||...:..|.|.::........|::.||:
Mouse   597 KKRRLVRPSSIVPLSKKVHR--NVRSGCD-VNPSCALCGSGSVNTMPPEIHYEAPLLERLSQLDS 658

  Fly   796 GYHPVLSFASDVSQSVHLEAVARQPDWQYRVM-RSQPKAIVKAMWKAERETIASGGVGGQGGSRR 859
            ..||||:|..||..|:|.:::.:. .||.:.. :.:|........:|......|..|
Mouse   659 CVHPVLAFPDDVPTSLHFQSMLKS-QWQNKPFDKIKPTKKFSLKHRATMPCSLSDPV-------- 714

  Fly   860 SGDAAKRRYIRRKERNNNSNKEAGSGAKAAAVAAGGAGGNGSSSVGGGDSGNGTGTATTSSSTTP 924
                       ||:|:...|...                              |........|.|
Mouse   715 -----------RKDRHKLVNSFL------------------------------TTAKLCHQQTRP 738

  Fly   925 TTT-----------PLVAN-TAARGKR-----QPQH-PTGANSSSSLWPDSRQRQRQRHHSPSST 971
            ..|           |:|.. ||.:.:|     .|.| ||  :|...|...|.:|.....|....:
Mouse   739 DRTHRQHLDGVGAVPMVERVTAPKAERLLHLPPPVHDPT--HSKMRLRDHSSERSEVLKHHTDMS 801

  Fly   972 SISALSG------AKKARKSATNSSSSNSTQQQQNHHGTKINNHHLNGYGDQWGEQSRSRRNSSP 1030
            |.|.|:.      :...|:.:|:|.:|..|..     |:::                 :...|.|
Mouse   802 SPSYLTATHHPPHSPLVRQLSTSSDTSTPTSS-----GSQV-----------------AASTSQP 844

  Fly  1031 SNSHKNERTSERRVRPIYDINNIVIPYSMLAQSKMEIIPYKEIPIPKWRIVDSDNDKGKHSSDES 1095
            ....:.|.:        :||||||||.|:.|.:::|.:.||||..|.||.||..:.||.
Mouse   845 VRRRRGESS--------FDINNIVIPMSVAATTRVEKLQYKEILTPSWREVDVQSLKGS------ 895

  Fly  1096 MERKLSNGCVASKSEELAKQQLPPPPDQDQEQPALQPPKVNGLKENQ-AVKHNNNNNTNNNNNKN 1159
                                     ||::.|:       :..|.:.. |..|
Mouse   896 -------------------------PDEENEE-------IEDLSDAAFAALH------------- 915

  Fly  1160 GLVNGNAKKDELKAAEDHDTQSKEDDDPKEKVVKPKLNGNLIKNPIDKTAETQDKIAQPAPEPPL 1224
                  ||.:|::.|....|.|          |.|:..|:......|  ..|..::....|..|.
Mouse   916 ------AKCEEMERARWLWTTS----------VPPQRRGSRSYRSSD--GRTTPQLGSANPSTPQ 962

  Fly  1225 PKRPKLETPTSNEVTK-ANGQLVQQQLESRESEEEPQHVDEDLSDEAFIMRHQRALLEERRRFET 1288
            |..|  :..:|:.::: ::||          |...|      :|.|.    |...|....|.
Mouse   963 PASP--DVSSSHSLSEFSHGQ----------SPRSP------ISPEL----HSAPLTPVARD--- 1002

  Fly  1289 FLKFPWSTRSRANRRVDSRAESSGANTPDPASPAPHLGGPGHDNESIPS------PLAYPLDAFN 1347
                  |.|..|       :|.:..:||:          .|.|.:|:..      ||||...|..
Mouse  1003 ------SLRHLA-------SEDTRCSTPE----------LGLDEQSVQPWERRTFPLAYSPQAEC 1044

  Fly  1348 ESGELLTGGQARQARRRTTSSKLKDQLERRSTTPDLRESYTVMPSPFEPLNFPLSDEVYQRLLAE 1412
            |. :|.....|.:..|||:.||...:.|...|:|           |..||.        .|.||.
Mouse  1045 EE-QLDAQDTAARCTRRTSGSKTGREAEVAPTSP-----------PVVPLK--------SRHLAA 1089

  Fly  1413 TYAPPR 1418
            |....|
Mouse  1090 TVTAQR 1095

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nsl1	NP_732069.3	PEHE	1250..>1325	CDD:291924	13/74 (18%)
Kansl1	NP_001359388.1	PEHE	879..997	CDD:405867	37/208 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846704
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28RWV
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S8286
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006248
OrthoInspector	1	1.000	-	-		otm42536
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22443
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4917
SonicParanoid	1	1.000	-	-		X4531
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.870