DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nsl1 and Kansl1l

DIOPT Version :9

Sequence 1:	NP_732069.3	Gene:	nsl1 / 41911	FlyBaseID:	FBgn0262527	Length:	1570	Species:	Drosophila melanogaster
Sequence 2:	XP_011236872.1	Gene:	Kansl1l / 68691	MGIID:	1915941	Length:	1026	Species:	Mus musculus

Alignment Length:	1412	Identity:	249/1412 - (17%)
Similarity:	408/1412 - (28%)	Gaps:	656/1412 - (46%)

- Green bases have known domain annotations that are detailed below.

  Fly   268 HLESPQPARTQQQSIQQMTPQSTTSSNNFLKDGAAGAVLEDQDIEEVLKA----LKTF--DGGHV 326
            |..||| |....|::..|:..||.:..|           |:.:.::|:::    ||..  :|..:
Mouse    68 HFASPQ-ASKHFQTVLLMSSNSTLNKYN-----------ENYNQKKVMESNCSKLKNVLCNGSSI 120

  Fly   327 NPDTICEFFDEVWEEAAPAAPLPPAPPENVV---DVPGAKPSCSG--ILVSGSNISQPNVI--IK 384
            ....||                 |:..||..   ::......|..  .:|..||:::...:  :.
Mouse   121 QLSKIC-----------------PSHSENEFIKKELSDTTSQCMKDIQIVLDSNLTKDANVDRLH 168

  Fly   385 QEQRPWQESHAELEQQQHVISRRIEFLLRRMRKLQARAMCRHASEEVVGIMEWSARS---SHKAP 446
            .:...|.:.:|.|:          :|...:::|               |:::.:.:.   || :.
Mouse   169 LQNCKWYQKNALLD----------KFTDTKIKK---------------GLLQCTQKKIGPSH-SD 207

  Fly   447 VPARSSTL-TEQE--ATVLSIVSGRPSSTFWEEQNKHPLPASQMSNVIRHI-ATAAKH------Q 501
            ||..||.. .|||  |.:|..||            |..:..||.....:|: ...|||      |
Mouse   208 VPTSSSAAEKEQEVNARLLHCVS------------KQKILLSQARRTQKHLQMLLAKHVVKHYGQ 260

  Fly   502 QICHSASGSSATLAPSSSWYNSCNSSALPMKRPRKNQLDASVATGATPTAPAPGAVTSRQAAGTT 566
            |                            ||...|:|| .::.....||.....::.........
Mouse   261 Q----------------------------MKFSMKHQL-PTMKIFHEPTTVLSNSLLEHTEIKPE 296

  Fly   567 GSATGSNTPRADDIVPGYDTYVTNELTH----VSGLLHTELREVQNAIDSDATESSSGGESADEM 627
            .:...|.....||...|:......|:..    .:||    |..|:..:|||||:|||..| .||.
Mouse   297 VNILASENKFWDDTNNGFSQCTAAEIQRFALSATGL----LSHVEEGLDSDATDSSSDDE-LDEY 356

  Fly   628 VTYNN----------------------NQQLSLPITRR--------AVWRYSRDRAAIALRWSWL 662
            ....|                      .:.:|||::..        ..|::..|||.:..||:||
Mouse   357 TIRKNVAVVFLCSGCPGTHYVDQAVLECRAISLPVSSECWDKSNSSTEWKWLVDRAQVGSRWTWL 421

  Fly   663 CSQLTDLEMKIRQHSDLYMDLTQSKGEIQLES-------------------TAKTSPSLAQPANG 708
            .:|:::||.||:|.:|::..:..|||.:.||.                   :..||.:...|...
Mouse   422 QAQISELEYKIQQLTDIHRQIRASKGIVILEECQLPKDILKKQIQFSNQAVSLNTSVNSQVPQRS 486

  Fly   709 IKEEPGSDYLCSRARPLVLSEFRKRKLFQTTNM-----------HTISKKAARPSNIKC------ 756
            .:..|..|:..|.:.|.:|....:::..|.|.:           .|.|..:::..:.||
Mouse   487 EEPLPEHDFEMSPSSPTLLLRNIEKQSAQLTEIINSLIAPLNLSPTSSPLSSKSCSHKCLANGIS 551

  Fly   757 ------------GCQW-------------------PQVPCTLCTGRTDP---------------- 774
                        ...|                   |.:.......||.|
Mouse   552 RSASENLDELSSSSSWLLNQKHSKKRRKDRTRLKSPSLAIMSTAARTRPLQSFHKRKLYRLSPTF 616

  Fly   775 -----TAPRD---LVETMMP--------------------QNRVALLDAGYHPVLSFASDVSQSV 811
                 |.|..   |..|..|                    :.:|:.||:.:|||||..|::...:
Mouse   617 YWTPETLPSKEAFLSSTQTPYTGSPFSWDNWEQSSRSHLLREQVSKLDSSFHPVLSLPSEIPLHL 681

  Fly   812 HLEAVARQPDWQYRVMRSQPKAIVKAMWKAERETIASGGVGGQGGSRRSGDAAKRRYIRRKERNN 876
            |.|.:.::.|.:                                     |:.|:.:::
Mouse   682 HFETLFKKTDMK-------------------------------------GELAENQFV------- 702

  Fly   877 NSNKEAGSGAKAAAVAAGGAGGNGSSSVGGGDSGNGTGTATTSSSTTPTTTPLVANTAARGKRQP 941
                                          ||.                   |::
Mouse   703 ------------------------------GDC-------------------LIS---------- 708

  Fly   942 QHPTGANSSSSLWPDSRQRQRQRHHSP-------SSTSISALSGAKKARKSATNSSSSNSTQQ-- 997
              |.....:|||      .|.:..:||       |..|:..|.|.||...|.|..:...:..:
Mouse   709 --PPPVQGTSSL------NQWRNGYSPICKPQIRSQPSVQLLQGRKKRHLSETALAGERTRFEEF 765

  Fly   998 --QQNHHG-----TKINNHHLNGYGDQWGEQSRSRRNSSPSNSHKNERTSERRVR--PIYDINNI 1053
              |::..|     |.::|.::            :.|..:||    ::.||.||:|  ..|||:||
Mouse   766 AFQRSEPGSHCNFTAVSNANV------------TSRTQNPS----SQNTSRRRLRSESSYDIDNI 814

  Fly  1054 VIPYSMLAQSKMEIIPYKEIPIPKWRIVDSDNDKGKHSSDESMERKLSNGCVASKSEELAKQQLP 1118
            |||.|::|.:|:|.:.||||..|:||.|
Mouse   815 VIPMSLVAPAKLEKLQYKEILTPRWRKV------------------------------------- 842

  Fly  1119 PPPDQDQEQPALQPPKVNGLKENQAVKHNNNNNTNNNNNKNGLVNGNAKKDELKAAEDHDTQSKE 1183
                      .|||     |.|     ||.|
Mouse   843 ----------VLQP-----LDE-----HNLN---------------------------------- 853

  Fly  1184 DDDPKEKVVKPKLNGNLIKNPIDKTAETQDKIAQPAPEPPLPKRPKLETPTSNEVTKANGQLVQQ 1248
                ||::
Mouse   854 ----KEEI--------------------------------------------------------- 857

  Fly  1249 QLESRESEEEPQHVDEDLSDEAFIMRHQRALLEERRRFETFLKFPWSTRSRANRRVDSRAESSGA 1313
                           |||||:.|.:||::....|:.|:..:.:..|..|:  ||......|....
Mouse   858 ---------------EDLSDDVFSLRHRKYEEREQARWSLWEQSKWHRRN--NRAYSKNVEGQDL 905

  Fly  1314 NTPDPASPAPHLGGPGHDNESIPSPLAYPLDAFN---ESGELLTGGQARQARRRTTSSKLKDQLE 1375
            ...:.:|   .||..  ...:..||...|.::.:   :....|..||..::.|          .|
Mouse   906 VLKEHSS---ELGSA--QQGTAESPFELPAESHSLCAQDSLSLNDGQEDKSLR----------WE 955

  Fly  1376 RRSTTPDLRESYTVMPSPFEPLNFPLSDEVYQRLLAETYAPPRSMTVSKRAKSKSISSNCDGGNT 1440
            ||:                    |||.||....||.:                       |....
Mouse   956 RRA--------------------FPLKDEDTAALLCQ-----------------------DERKD 977

  Fly  1441 FTGGSGSRRSSK--CKIKPNGQLNGQLNGHPAAAKLNGIDAANEGGI 1485
            .|||:.:....:  |...|.       :|||...:|:|::.....||
Mouse   978 QTGGTSTAFHDEVFCSTTPE-------SGHPPKMQLDGMEEYKSFGI 1017

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nsl1	NP_732069.3	PEHE	1250..>1325	CDD:291924	16/74 (22%)
Kansl1l	XP_011236872.1	PEHE	834..954	CDD:405867	40/303 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846703
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28RWV
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	149	1.000	Inparanoid score	I4377
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm42536
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR22443
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	7	6.940