Protein Alignment nsl1 and Kansl1

DIOPT Version :10

• Sequence 1: NP_732069.3
• Gene: nsl1 / 41911
• FlyBaseID: FBgn0262527
• Length: 1570
• Species: Drosophila melanogaster
• Sequence 2: NP_001414656.1
• Gene: Kansl1 / 360642
• RGDID: 1311429
• Length: 1100
• Species: Rattus norvegicus
• Alignment Length: 1503
• Identity: 315/1503 - (20%)
• Similarity: 490/1503 - (32%)
• Gaps: 588/1503 - (39%)

  Fly    88 NAKASNEPMGLSTAPTPHSTTSPNPSTDTAAASTSAVEHNNNDSNSTSAGNST----------SA 142
            :|.|....:....|| |.||.||..:            .||.::|...:.|.|          |.
  Rat    10 DAAAEAHHIRFKLAP-PSSTLSPGSA------------ENNGNANILISANGTKRKAIAAEDPSL 61

  Fly   143 D--NSSTPKDNSTAQ------LLADLT-------INFEETISAEICLRKTLPDVS---------L 183
            |  |:.|.:|....|      |.:|:|       :..:...|.:..| |:.|.:|         |
  Rat    62 DFRNNPTKEDLGKLQPLVASYLCSDVTSVPSKESLKLQGVFSKQTVL-KSHPLLSQSYELRAELL 125

  Fly   184 GKEPVPPASVLAVATSSTSAGSALSLSAVD----EVTKIEIDNIEERLSQLDGNATGRPEEHVAP 244
            |::||...|:..:.|.:||..:||..:.|:    ::||....:..:..|.|:|.
  Rat   126 GRQPVLEFSLENLRTMNTSGQTALPQAPVNGLAKKLTKSSTHSDHDNSSSLNGG----------- 179

  Fly   245 PSVPVPVQEAPNTPTRPQAPPSAHLESPQPARTQQQSIQQMTPQSTTSSNNFLKDGAAGAVLEDQ 309
                                          .|:...|..|......:.|.| ||.|.....|..:
  Rat   180 ------------------------------KRSLTSSSLQGGEVGGSDSGN-LKGGMTNCTLPHR 213

  Fly   310 DIEEVLKALKTFDGGHVNPDTICEFFDEVWEEAAPAAPLPPAPPENVVDVPGAKPS--CSGILVS 372
            .::.....|      :.|..|:.:                  .|.|.::.|..:.|  .|....|
  Rat   214 SLDTQHTTL------YSNNSTVNK------------------SPVNSMEQPALQGSSRLSPSTDS 254

  Fly   373 GSNISQPNVIIKQEQRPWQE---SHAELEQQQHVISRR---IEFLLRRMRK----LQARAMCRHA 427
            .||::...:.:|:.  |...   |..:.:.:...:.||   ||...||::|    :||:.:.||.
  Rat   255 CSNLTSVKLEVKKS--PLSSILFSALDSDTRITALLRRQADIEIRARRLQKRLQVVQAKQVERHL 317

  Fly   428 SEEVVGIMEWSARSSHKAP----VPARSSTLTEQEATVLSIVSGRPSSTFWEEQNKHPLPASQMS 488
            ..::.|.:|   ::..|.|    :.:||..:..::|
  Rat   318 QHQLGGFLE---KTLSKLPNLESLRSRSQLMLTRKA----------------------------- 350

  Fly   489 NVIRHIATAAKHQQICHSASGSSATLAPSSSWYNSCNSSALPMKRPRKNQLDASVATGATPTAPA 553
                                                 .:||
  Rat   351 -------------------------------------EAAL------------------------ 354

  Fly   554 PGAVTSRQAAGTTGSATG-SNTPRADDIVPGYDTYVTNELTHVSGLLHTELREVQNAIDSDATES 617
                  |:||..|.::.| ||..::|.|....:.:.      .||:  ..||..:.|.|||.|:|
  Rat   355 ------RKAASETATSEGLSNFLKSDSISEELERFT------ASGI--ANLRCSEQAFDSDVTDS 405

  Fly   618 SSGGES--ADEMVTYNNNQQLSLPITRRAVWRYSRDRAAIALRWSWLCSQLTDLEMKIRQHSDLY 680
            ||||||  .:|.:|..:.:|..:|:.||:.||::.|||||..||:||.:.::|||.:|||.:|:|
  Rat   406 SSGGESDIEEEELTRADPEQCHVPLKRRSEWRWAADRAAIVSRWNWLQAHVSDLEYRIRQQTDIY 470

  Fly   681 MDLTQSKGEI---------------QLESTAKTS-------PSLAQPA----------------- 706
            ..:..:||.|               .|.|..||.       .|::||:
  Rat   471 KQIRANKGLIVLGEASFPDHTTDLLSLSSEVKTDHGSDKLIESVSQPSENHGIPVSHITESLSTK 535

  Fly   707 --------NGI---------KEEPG---------------------SDYLCSRARPLVLSEFRKR 733
                    ||:         .:.||                     ||..|..||...:...:||
  Rat   536 TCGALRPVNGVVNSLQPVLADQVPGDSSDAEEQIHKKQRLNLVSSSSDGTCVAARTRPVLSCKKR 600

  Fly   734 KLFQTTNMHTISKKAARPSNIKCGCQWPQVPCTLCTGRTDPTAPRDLVETMMPQNRVALLDAGYH 798
            :|.:.:::..:|||..|  ||:.||. ....|.||...:..|.|.::........|::.||:..|
  Rat   601 RLVRPSSIVPLSKKVHR--NIRSGCD-VNPSCALCGSGSVNTMPPEIHYEAPLLERLSQLDSCVH 662

  Fly   799 PVLSFASDVSQSVHLEAVARQPDWQYRVM-RSQPKAIVKAMWKAERETIASGGVGGQGGSRRSGD 862
            |||:|..||..|:|.:::.:. .||.:.. :.:|........:|......|..|
  Rat   663 PVLAFPDDVPTSLHFQSMLKS-QWQNKPFDKIKPTKKFSLKHRAPMPCSLSDPV----------- 715

  Fly   863 AAKRRYIRRKERNNNSNKEAGSGAKAAAVAAGGAGGNGSSSVGGGDSGNGTGTATTSS----STT 923
                    ||:|:...|                                  ...|||.    .|.
  Rat   716 --------RKDRHKLVN----------------------------------SFLTTSKLSHHQTR 738

  Fly   924 PTTT-----------PLVAN-TAARGKR-----QPQH-PTGANSSSSLWPDSRQRQRQRHHSPSS 970
            |..|           |:|.. ||.:.:|     .|.| ||            ..:.|.|.||...
  Rat   739 PDRTHRQHLDDVGAVPMVERVTAPKAERLLHLPPPVHDPT------------HSKLRLRDHSSER 791

  Fly   971 TSISALSGAKKARKSATNSSSSNSTQQQQNHHGTKINNHHLNGYGDQWGEQSRSRRNSSPSNSHK 1035
            :.:        .:.....||||..|....:.|...:.            :.|.|...|:|::|..
  Rat   792 SEV--------LKHHTDMSSSSYLTATHHSPHSPLVR------------QLSTSSDTSTPTSSSS 836

  Fly  1036 NERTS------ERRVRPIYDINNIVIPYSMLAQSKMEIIPYKEIPIPKWRIVDSDNDKGKHSSDE 1094
            ....|      .||....:||||||||.|:.|.:::|.:.||||..|.||.||..:.||.
  Rat   837 QVAASTSQPVRRRRGESSFDINNIVIPMSVAATTRVEKLQYKEILTPSWREVDLQSLKGS----- 896

  Fly  1095 SMERKLSNGCVASKSEELAKQQLPPPPDQDQEQPALQPPKVNGLKENQ-AVKHNNNNNTNNNNNK 1158
                                      ||::.|:       :..|.:.. |..|
  Rat   897 --------------------------PDEENEE-------IEDLSDAAFAALH------------ 916

  Fly  1159 NGLVNGNAKKDELKAAEDHDTQSKEDDDPKEKVVKPKLNGNLIKNPIDKTAETQDKIAQPAPEPP 1223
                   ||.:|::.|....|.|          |.|:..|:......|  ..|..::....|..|
  Rat   917 -------AKCEEMERARWLWTTS----------VPPQRRGSRSYRSSD--GRTTPQLGSANPSTP 962

  Fly  1224 LPKRPKLETPTSNEVTK-ANGQLVQQQLESRESEEEPQHVDEDLSDEAFIMRHQRALLEERRRFE 1287
            .|..|  :..:|:.::: ::||          |...|      :|.|.    |...|....|.
  Rat   963 QPASP--DVSSSHSLSEFSHGQ----------SPRSP------ISPEL----HSAPLTPVARD-- 1003

  Fly  1288 TFLKFPWSTRSRANRRVDSRAESSGANTPDPASPAPHLGGPGHDNESIPS------PLAYPLDAF 1346
                   |.|..|       :|.:..:||:          .|.|.:|:..      ||||...|
  Rat  1004 -------SLRHLA-------SEDTRCSTPE----------LGLDEQSVQPWERRTFPLAYSPQA- 1043

  Fly  1347 NESGELLTG-GQARQARRRTTSSKLKDQLERRSTTPDLRESYTVMPSPFEPLNFPLSDEVYQRLL 1410
             |..|.|.. ..|.:..|||:.||...:.|...|:|           |..||.        .|.|
  Rat  1044 -ECDEQLDAQDTAARCTRRTSGSKTGRETEVAPTSP-----------PVVPLK--------SRHL 1088

  Fly  1411 AETYAPPR 1418
            |.|.|..|
  Rat  1089 AATVAAQR 1096

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nsl1	NP_732069.3	PRK08581	100..>323	CDD:236304	52/260 (20%)
		PEHE	1248..>1323	CDD:464607	13/74 (18%)
Kansl1	NP_001414656.1	None