DRSC/TRiP Functional Genomics Resources

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Protein Alignment nsl1 and KANSL1

DIOPT Version :9

Sequence 1:NP_732069.3 Gene:nsl1 / 41911 FlyBaseID:FBgn0262527 Length:1570 Species:Drosophila melanogaster
Sequence 2:NP_001180395.1 Gene:KANSL1 / 284058 HGNCID:24565 Length:1105 Species:Homo sapiens


Alignment Length:1487 Identity:310/1487 - (20%)
Similarity:482/1487 - (32%) Gaps:602/1487 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly    88 NAKASNEPMGLSTAPTPHSTTSPNPSTDTAAASTSAVEHNNNDSNSTSAGNST----------SA 142
            :|.|....:....|| |.||.||..:            .||.::|...|.|.|          |.
Human    10 DAAAEAHHIRFKLAP-PSSTLSPGSA------------ENNGNANILIAANGTKRKAIAAEDPSL 61

  Fly   143 D--NSSTPKDNSTAQ------LLADLT-------INFEETISAEICLRKTLPDVS---------L 183
            |  |:.|.:|....|      |.:|:|       :..:...|.:..| |:.|.:|         |
Human    62 DFRNNPTKEDLGKLQPLVASYLCSDVTSVPSKESLKLQGVFSKQTVL-KSHPLLSQSYELRAELL 125

  Fly   184 GKEPVPPASVLAVATSSTSAGSALSLSAVDEVTK--------IEIDNIEE--------RLSQLDG 232
            |::||...|:..:.|.:||..:||..:.|:.:.|        .:.||...        ..|.|.|
Human   126 GRQPVLEFSLENLRTMNTSGQTALPQAPVNGLAKKLTKSSTHSDHDNSTSLNGGKRALTSSALHG 190

  Fly   233 NATGRPEE--------HVAPPSVPVPVQEAPNTPTRPQAPPSAHLESPQPARTQQQSIQQMTPQS 289
            ...|..|.        :...|...:.|:..........|..|:.....|||   .|...:::|.:
Human   191 GEMGGSESGDLKGGMTNCTLPHRSLDVEHTTLYSNNSTANKSSVNSMEQPA---LQGSSRLSPGT 252

  Fly   290 TTSSNNFLKDGAAGAVLEDQDIEEVLKALKTFDGGHVNPDTICEFFDEVWEEAAPAAPLPPAPPE 354
            .:|||.                           ||                              
Human   253 DSSSNL---------------------------GG------------------------------ 260

  Fly   355 NVVDVPGAKPSCSGILVSGSNISQPNVIIKQEQRPWQESHAELEQQQHVISRRIEFLLRRMRKLQ 419
              |.:.|.|...|.||.|..:.......:.:.|       |::|.:    :||::   :|::.:|
Human   261 --VKLEGKKSPLSSILFSALDSDTRITALLRRQ-------ADIESR----ARRLQ---KRLQVVQ 309

  Fly   420 ARAMCRHASEEVVGIMEWSARSSHKAPVPARSSTLTEQEATVLSIVSGRPSSTFWEEQNKHPLPA 484
            |:.:.||...::.|.:|               .||::                         || 
Human   310 AKQVERHIQHQLGGFLE---------------KTLSK-------------------------LP- 333

  Fly   485 SQMSNVIRHIATAAKHQQICHSASGSSATLAPSSSWYNSCNSSALPMKRPRKNQLDASVATGATP 549
                                                    |..:|   |||...:....|..|. 
Human   334 ----------------------------------------NLESL---RPRSQLMLTRKAEAAL- 354

  Fly   550 TAPAPGAVTSRQAAGTTGSATG-SNTPRADDIVPGYDTYVTNELTHVSGLLHTELREVQNAIDSD 613
                      |:||..|.::.| ||..:::.|....:.:.      .||:  ..||..:.|.|||
Human   355 ----------RKAASETTTSEGLSNFLKSNSISEELERFT------ASGI--ANLRCSEQAFDSD 401

  Fly   614 ATESSSGGES--ADEMVTYNNNQQLSLPITRRAVWRYSRDRAAIALRWSWLCSQLTDLEMKIRQH 676
            .|:|||||||  .:|.:|..:.:|..:|:.||:.|:::.|||||..||:||.:.::|||.:|||.
Human   402 VTDSSSGGESDIEEEELTRADPEQRHVPLRRRSEWKWAADRAAIVSRWNWLQAHVSDLEYRIRQQ 466

  Fly   677 SDLYMDLTQSKGEI----------------QLESTAKT--------------------------S 699
            :|:|..:..:||.|                .|.|..||                          |
Human   467 TDIYKQIRANKGLIVLGEVPPPEHTTDLFLPLSSEVKTDHGTDKLIESVSQPLENHGAPIIGHIS 531

  Fly   700 PSLA-------QPANGI---------KEEPG---------------------SDYLCSRARPLVL 727
            .||:       :|.||:         ...||                     ||..|..||...:
Human   532 ESLSTKSCGALRPVNGVINTLQPVLADHIPGDSSDAEEQLHKKQRLNLVSSSSDGTCVAARTRPV 596

  Fly   728 SEFRKRKLFQTTNMHTISKKAARPSNIKCGCQWPQVPCTLCTGRTDPTAPRDLVETMMPQNRVAL 792
            ...:||:|.:..::..:|||..|.|.|:.||. ....|.||...:..|.|.::........|::.
Human   597 LSCKKRRLVRPNSIVPLSKKVHRNSTIRPGCD-VNPSCALCGSGSINTMPPEIHYEAPLLERLSQ 660

  Fly   793 LDAGYHPVLSFASDVSQSVHLEAVARQPDWQYRVMRSQPKAIVKAMWKAERETIASGGVGGQGGS 857
            ||:..||||:|..||..|:|.:::.:. .||     ::|...:|...|...:..|.     ..||
Human   661 LDSCVHPVLAFPDDVPTSLHFQSMLKS-QWQ-----NKPFDKIKPPKKLSLKHRAP-----MPGS 714

  Fly   858 RRSGDAAKRRYIRRKERNNNSNKEAGSGAKAAAVAAGGAGGNGSSSVGGGDSGNGTGTATTSSST 922
              ..|:|      ||:|    :|...|....|.:                          :...|
Human   715 --LPDSA------RKDR----HKLVSSFLTTAKL--------------------------SHHQT 741

  Fly   923 TPTTT-----------PLVAN-TAARGKR---------QP------------------QHPTGAN 948
            .|..|           |:|.. ||.:.:|         .|                  :|.|..:
Human   742 RPDRTHRQHLDDVGAVPMVERVTAPKAERLLNPPPPVHDPNHSKMRLRDHSSERSEVLKHHTDMS 806

  Fly   949 SSSSLWPDSRQRQRQRHHSPSSTSISALSGAKKARKSATNSSSSNSTQQQQNHHGTKINNHHLNG 1013
            |||.|        ...||.|.|..:..||.:..:...|::||...::..||              
Human   807 SSSYL--------AATHHPPHSPLVRQLSTSSDSPAPASSSSQVTASTSQQ-------------- 849

  Fly  1014 YGDQWGEQSRSRRNSSPSNSHKNERTSERRVRPIYDINNIVIPYSMLAQSKMEIIPYKEIPIPKW 1078
                   ..|.||..|.                 :||||||||.|:.|.:::|.:.||||..|.|
Human   850 -------PVRRRRGESS-----------------FDINNIVIPMSVAATTRVEKLQYKEILTPSW 890

  Fly  1079 RIVDSDNDKGKHSSDESMERKLSNGCVASKSEELAKQQLPPPPDQDQEQPALQPPKVNGLKENQ- 1142
            |.||..:.||.                               ||::.|:       :..|.:.. 
Human   891 REVDLQSLKGS-------------------------------PDEENEE-------IEDLSDAAF 917

  Fly  1143 AVKHNNNNNTNNNNNKNGLVNGNAKKDELKAAEDHDTQSKEDDDPKEKVVKPKLNGNLIKNPIDK 1207
            |..|                   ||.:|::.|....|.|          |.|:..|:......| 
Human   918 AALH-------------------AKCEEMERARWLWTTS----------VPPQRRGSRSYRSSD- 952

  Fly  1208 TAETQDKIAQPAPEPPLPKRPKLETPTSNEVTK-ANGQL----VQQQLESRE----SEEEPQHVD 1263
             ..|..::....|..|.|..|  :..:|:.::: ::||.    :..:|.|..    :.:.|:|: 
Human   953 -GRTTPQLGSANPSTPQPASP--DVSSSHSLSEYSHGQSPRSPISPELHSAPLTPVARDTPRHL- 1013

  Fly  1264 EDLSDEAFIMRHQRALLEERRRFETFLKFPWSTRSRANRRVDSRAESSGANTPDPASPAPHLGGP 1328
              .|::......:..|.|:..:       ||      .||....|.|..|...|           
Human  1014 --ASEDTRCSTPELGLDEQSVQ-------PW------ERRTFPLAHSPQAECED----------- 1052

  Fly  1329 GHDNESIPSPLAYPLDAFNESGELLTGGQARQAR--RRTTSSKLKDQLERRSTTPDL 1383
                         .|||           |.|.||  |||:.||...:.|...|:|.:
Human  1053 -------------QLDA-----------QERAARCTRRTSGSKTGRETEAAPTSPPI 1085

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nsl1NP_732069.3 PEHE 1250..>1325 CDD:291924 15/78 (19%)
KANSL1NP_001180395.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 145..211 11/65 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 225..263 13/99 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 399..426 13/26 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 733..857 30/178 (17%)
Required for activation of KAT8 histone acetyltransferase activity 850..882 15/48 (31%)
Sufficient for interaction with KAT8 883..1105 64/325 (20%)
PEHE 885..1003 CDD:405867 34/188 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 938..1034 19/109 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1061..1105 10/25 (40%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165156297
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_28RWV
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0006248
OrthoInspector 1 1.000 - - otm40459
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR22443
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4917
SonicParanoid 1 1.000 - - X4531
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
87.920

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