Protein Alignment nsl1 and KANSL1L

DIOPT Version :10

• Sequence 1: NP_732069.3
• Gene: nsl1 / 41911
• FlyBaseID: FBgn0262527
• Length: 1570
• Species: Drosophila melanogaster
• Sequence 2: XP_005246385.1
• Gene: KANSL1L / 151050
• HGNCID: 26310
• Length: 1020
• Species: Homo sapiens
• Alignment Length: 1335
• Identity: 237/1335 - (17%)
• Similarity: 392/1335 - (29%)
• Gaps: 621/1335 - (46%)

  Fly   258 PTRPQAPPSAHLESPQPA--RTQQQSIQQM----TPQSTTSSNNFLKDGAAGAVLEDQDIEEV-- 314
            |:..::....::|||:..  :.:..:..||    ||:.|.:: ||:.....|:....:..:.|
Human    52 PSTMESDKMLYMESPRTVDEKLKGDTFSQMLGFPTPEPTLNT-NFVNLKHFGSPQSSKHYQTVFL 115

  Fly   315 LKALKTFDGGHVNPDTICEFFDEVWEEAAPAAPLPPAPPENVVDVPGAKPSCS---GILVSGSNI 376
            :::..|.:..:                            ||.......:|||:   .||.:||||
Human   116 MRSNSTLNKHN----------------------------ENYKQKKLGEPSCNKLKNILYNGSNI 152

  Fly   377 -------SQPNVIIKQEQRPWQESHAE-LEQQQHVISRRI-------EFLLRRMRKLQARAMCRH 426
                   |.....||:|  |..::.:: ::..|.::...|       :..|:..:..|..|:...
Human   153 QLSKICLSHSEEFIKKE--PLSDTTSQCMKDVQIILDSNITKDTNVDKVQLQNCKWYQENALLDK 215

  Fly   427 ASEEVV--GIMEWSARS---SHKAPVPARSSTLTEQE---ATVLSIVSGRPSSTFWEEQNKHPLP 483
            .::..:  |::..:.:.   .| :.||..||...::|   |.:|..||            |..:.
Human   216 VTDAEIKKGLLHCTQKKIVPGH-SNVPVSSSAAEKEEEVHARLLHCVS------------KQKIL 267

  Fly   484 ASQMSNVIRHI-ATAAKH------QQICHSASGSSATLAPSSSWYNSCNSSALPMKRPRKNQLDA 541
            .||.....:|: ...|||      ||                            ||...|:|| .
Human   268 LSQARRTQKHLQMLLAKHVVKHYGQQ----------------------------MKLSMKHQL-P 303

  Fly   542 SVATGATPTAPAPGAVTSRQAAGTTGSATGSNTPRADDIVPGYDTYVT-NEL------------- 592
            .:.|...||                 :..|::.|:..:|.|..:|... |:|
Human   304 KMKTFHEPT-----------------TILGNSLPKCTEIKPEVNTLTAENKLWDDAKNGFARCTA 351

  Fly   593 -------THVSGLLHTELREVQNAIDSDATESSSGGESADEMVTYNNNQQLSLPITRRAVWRYSR 650
                   ...:||    |..|:..:|||||:||| .:..||.....|     :.:.....|::..
Human   352 AEIQRFAFSATGL----LSHVEEGLDSDATDSSS-DDDLDEYTLRKN-----VAVNCSTEWKWLV 406

  Fly   651 DRAAIALRWSWLCSQLTDLEMKIRQHSDLYMDLTQSKGEIQLE---------------------- 693
            |||.:..||:||.:|::|||.||:|.:|::..:..|||.:.||
Human   407 DRARVGSRWTWLQAQISDLECKIQQLTDIHRQIRASKGIVVLEECQLPKDILKKQMQFADQAASL 471

  Fly   694 ---------------------STAKTSPSL----------------------------AQP---- 705
                                 ..:.:||:|                            :.|
Human   472 NILGNPQVPQECQDPVPEQDFEMSPSSPTLLLRNIEKQSAQLTEIINSLIAPLNLSPTSSPLSSK 536

  Fly   706 -------ANGIKEEPGSD---------------------------------YLCSRARPLVLSEF 730
                   ||||......:                                 ::.:.||...|..|
Human   537 SCSHKCLANGIYRSASENLDELSSSSSWLLNQKHSKKKRKDRTRLKSSSLTFMSTSARTRPLQSF 601

  Fly   731 RKRKLFQTTNMHTISKKAARPSNIKCGCQWPQVPCTLCTGRTDPTAPRDLVETMMPQNRVALLDA 795
            .||||::.:.....:.:.. ||.........|:|| |.:..|..:...: .|:.:.:..|:.||:
Human   602 HKRKLYRLSPTFYWTPQTL-PSKETAFLNTTQMPC-LQSASTWSSYEHN-SESYLLREHVSELDS 663

  Fly   796 GYHPVLSFASDVSQSVHLEAVARQPDWQYRVMRSQPKAIVKAMWKAERETIASGGVGGQGGSRRS 860
            .:|.|||..|||....|.|.:.:             |..:|
Human   664 SFHSVLSLPSDVPLHFHFETLLK-------------KTEIK------------------------ 691

  Fly   861 GDAAKRRYIRRKERNNNSNKEAGSGAKAAAVAAGGAGGNGSSSVGGGDSGNGTGTATTSSSTTPT 925
            |:.|:.:::...
Human   692 GNLAENKFVDEY----------------------------------------------------- 703

  Fly   926 TTPLVANTAARGKRQPQHPTGANSSSSLWPDSRQRQRQRHHSP-------SSTSISALSGAKKAR 983
               :::            |:..:|:.:.|        :..:||       |.:|...|.|.||..
Human   704 ---IIS------------PSPVHSTLNQW--------RNGYSPICKPQIRSESSAQLLQGRKKRH 745

  Fly   984 KSATNSSSSNSTQQQQNHHGTKINNHHLNGYGDQWGEQSRSRRNSSPSNSHKNERTSERRVR--P 1046
            .|.|........::....| |:..:|      ..:...|.....|...||.:|  |:.||:|  .
Human   746 LSETALGERTKLEESDFQH-TESGSH------SNFTAVSNVNVLSRIQNSSRN--TARRRLRSES 801

  Fly  1047 IYDINNIVIPYSMLAQSKMEIIPYKEIPIPKWRIVDSDNDKGKHSSDESMERKLSNGCVASKSEE 1111
            .|||:|||||.|::|.:|:|.:.||||..|.||:|
Human   802 SYDIDNIVIPMSLVAPAKLEKLQYKEILTPSWRMV------------------------------ 836

  Fly  1112 LAKQQLPPPPDQDQEQPALQPPKVNGLKENQAVKHNNNNNTNNNNNKNGLVNGNAKKDELKAAED 1176
                             .|||                            |...|..|:|:
Human   837 -----------------VLQP----------------------------LDEYNLGKEEI----- 851

  Fly  1177 HDTQSKEDDDPKEKVVKPKLNGNLIKNPIDKTAETQDKIAQPAPEPPLPKRPKLETPTSNEVTKA 1241
                                                                             
Human   852 ----------------------------------------------------------------- 851

  Fly  1242 NGQLVQQQLESRESEEEPQHVDEDLSDEAFIMRHQRALLEERRRFETFLKFPWSTRSRANRRVDS 1306
                                  ||||||.|.:||::....|:.|:..:.:..|..|       :|
Human   852 ----------------------EDLSDEVFSLRHKKYEEREQARWSLWEQSKWHRR-------NS 887

  Fly  1307 RAESSGANTPD-----------------PASPAPHLGGPG--HDNESIPSPLAYPLDAFNESGEL 1352
            ||.|......|                 .|||      ||  .:|:.:   .||.|.:.|:|.|.
Human   888 RAYSKNVEGQDLLLKEYPNNFSSSQQCAAASP------PGLPSENQDL---CAYGLPSLNQSQET 943

  Fly  1353 LTGGQARQA--------RRRTTSSKLKDQLERRST 1379
            .:....|:|        .......:.|||:||.||
Human   944 KSLWWERRAFPLKGEDMAALLCQDEKKDQVERSST 978

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nsl1	NP_732069.3	PRK08581	100..>323	CDD:236304	14/72 (19%)
		PEHE	1248..>1323	CDD:464607	21/91 (23%)
KANSL1L	XP_005246385.1	PEHE	828..948	CDD:464607	42/302 (14%)