DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9590 and FAM114A1

DIOPT Version :9

Sequence 1:	NP_650488.1	Gene:	CG9590 / 41907	FlyBaseID:	FBgn0038360	Length:	460	Species:	Drosophila melanogaster
Sequence 2:	NP_001362721.1	Gene:	FAM114A1 / 92689	HGNCID:	25087	Length:	563	Species:	Homo sapiens

Alignment Length:	501	Identity:	130/501 - (25%)
Similarity:	214/501 - (42%)	Gaps:	121/501 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 VEKEQQPQEKVSSRNDAKGTAENQEKLETPRISAPATASATSSSWGLWG-GKLSSVLTTATEGLG 100
            |..|.:|:.::..:.      :|...:::|      .:....:.||.|| ..|||...|...||.
Human    98 VSLEAEPRSEIPLQE------QNYLAVDSP------PSGGGWAGWGSWGKSLLSSASATVGHGLT 150

  Fly   101 TITTQ---------VNQGL------NQIIGVPDPEELARINVAEKAEKAAKAPPEENVDDEKESS 150
            .:..:         ||.|.      |...|||:      |..|...:..|::||      ...||
Human   151 AVKEKAGATLRIHGVNSGSSEGAQPNTENGVPE------ITDAATDQGPAESPP------TSPSS 203

  Fly   151 AAFGL-----DFVTNLGSKVLNTGLDTLEGIGKKTMTILQDNDPKLMNKRKLLGLEANSPNLSAV 210
            |:.|:     :.|.|.|..||..|||.||.||||||.:|.::||.....:.|:   ..:.:||.:
Human   204 ASRGMLSAITNVVQNTGKSVLTGGLDALEFIGKKTMNVLAESDPGFKRTKTLM---ERTVSLSQM 265

  Fly   211 LLEAKKEADQMEQSLQQLQLKRQKAQLRFEILFENYCGLVHFEALEILSKESRLKLDTLLDAVSG 275
            |.|||::  :.::..|||.::|   ...:.:||:.|.||.|.|||||||.||..|:.:.|.::.|
Human   266 LREAKEK--EKQRLAQQLTMER---TAHYGMLFDEYQGLSHLEALEILSNESESKVQSFLASLDG 325

  Fly   276 NARAELQETINEVKELIELEDLD---------VESEGDYEAEELSERL-----AAT-------IK 319
            .....|:..:..:|::...::|:         :|.:|:..|..|:|.|     |||       :|
Human   326 EKLELLKNDLISIKDIFAAKELENEENQEEQGLEEKGEEFARMLTELLFELHVAATPDKLNKAMK 390

  Fly   320 DAELGIQFD------DIANHWTQSLSWLTSEEATAAD---------------------LEQAYAK 357
            .|...::.|      |:|.         .|||.|..:                     :|:.|..
Human   391 RAHDWVEEDQTVVSVDVAK---------VSEEETKKEEKEEKSQDPQEDKKEEKKTKTIEEVYMS 446

  Fly   358 SIHALSEACALEMCKLHKIAELLL-----VKPHHSTANEVDGVVNLCQQFNGHLQGLSHRFA--- 414
            ||.:|:|..|..:.:|||:|||:|     .||....|..   ::.|.......:..||.:|.
Human   447 SIESLAEVTARCIEQLHKVAELILHGQEEEKPAQDQAKV---LIKLTTAMCNEVASLSKKFTNSL 508

  Fly   415 AVLSGKSETEESKGRVSTFFSEMLSAVQFIEKAYKLFTPILQMGAV 460
            ..:....:.|.....:|:...|..::..:|:.|::|..|:||:..:
Human   509 TTVGSNKKAEVLNPMISSVLLEGCNSTTYIQDAFQLLLPVLQVSHI 554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9590	NP_650488.1	DUF719	80..249	CDD:283086	59/189 (31%)
FAM114A1	NP_001362721.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..84
		DUF719	135..299	CDD:368390	55/183 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	165..206		15/52 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	411..436		4/24 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144568
Domainoid	1	1.000	68	1.000	Domainoid score	I9734
eggNOG	1	0.900	-	-		E1_2C2HB
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	127	1.000	Inparanoid score	I4693
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49595
OrthoDB	1	1.010	-	-		D403298at33208
OrthoFinder	1	1.000	-	-		FOG0003527
OrthoInspector	1	1.000	-	-		otm41794
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12842
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2406
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.870