DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9590 and Fam114a1

DIOPT Version :9

Sequence 1:	NP_650488.1	Gene:	CG9590 / 41907	FlyBaseID:	FBgn0038360	Length:	460	Species:	Drosophila melanogaster
Sequence 2:	NP_080943.3	Gene:	Fam114a1 / 68303	MGIID:	1915553	Length:	569	Species:	Mus musculus

Alignment Length:	455	Identity:	115/455 - (25%)
Similarity:	191/455 - (41%)	Gaps:	84/455 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 PATASATSSSWGLWGGKLSSVLTTATEGLGTITTQVNQGLNQII---------GVP-DPEELARI 125
            |::.:...:.||.||..|.| ..:||.|.|....:...|....|         |.| |.|.....
Mouse   120 PSSQAGRWAGWGSWGKSLLS-SASATVGHGLTAVKEKAGATLRIHSANSASPEGAPTDAENGISG 183

  Fly   126 NVAEKAEKA--AKAPPEENVDDEKESSAAFGLDFVTNLGSKVLNTGLDTLEGIGKKTMTILQDND 188
            ||....:.|  ...||.......:...:|. .:.|.|.|..||..|||.||.||||||.:|.::|
Mouse   184 NVTPDQDPARGPHTPPPPGAAGSRGMLSAL-TNVVQNTGKSVLTGGLDALEFIGKKTMIVLAESD 247

  Fly   189 PKLMNKRKLLGLEANSPNLSAVLLEAKKEADQMEQSLQQLQLKRQKAQLRFEILFENYCGLVHFE 253
            |.....:.|:   ..:.:||.:|.|||::  :.::..|||.::|   ...:.:||:.|.||.|.|
Mouse   248 PGFKRTKTLM---ERTVSLSQMLREAKEK--EKQRLAQQLTVER---TAHYGMLFDEYQGLSHLE 304

  Fly   254 ALEILSKESRLKLDTLLDAVSGNARAELQETINEVKELIELEDLDVESEGDYEA----------- 307
            ||||||.||..|:.:.|.::.|. :.||.:     .:||.::|:.|..|.:.||
Mouse   305 ALEILSNESESKVQSFLTSLDGE-KLELLK-----NDLISIKDIFVAKESENEANPEEQGLEESG 363

  Fly   308 EELSERLAATIKDAELGIQFDDIANHWTQSLSWLTSEEAT------------------------- 347
            ||.:..|...:.:..:....|.:.....::..|:..:::.
Mouse   364 EEFARMLTELLFELHVAATPDKLNKAMKKAHDWVEEDQSVVSIDVAKGSEEEEKEEGKEEKAEEP 428

  Fly   348 ---------AADLEQAYAKSIHALSEACALEMCKLHKIAELLL-----VKPHHSTANEVDGVVNL 398
                     |..:|:.|..||.:|:|..|..:.:|||:|||:|     .||....|..   ::.|
Mouse   429 EEDKTGGQGAKTVEEVYMLSIESLAEVTARCIEQLHKVAELILHGQEEEKPAQDQARV---LIKL 490

  Fly   399 CQQFNGHLQGLSHRFA---AVLSGKSETEESKGRVSTFFSEMLSAVQFIEKAYKLFTPILQMGAV 460
            .......:..||.:|.   ..:....:.|.....:::.|.|..::..:::.|.:|..|:||:..:
Mouse   491 TTAMCNEVTSLSKKFTNSLTTVGSNKKAEVLNPMINSVFLEGSNSTTYVQDALQLLLPVLQVSHI 555

Fly 461 460
Mouse 556 555

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9590	NP_650488.1	DUF719	80..249	CDD:283086	55/180 (31%)
Fam114a1	NP_080943.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..87
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	102..126		1/5 (20%)
		DUF719	126..300	CDD:283086	55/183 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	165..208		9/42 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	404..439		0/34 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834688
Domainoid	1	1.000	67	1.000	Domainoid score	I9785
eggNOG	1	0.900	-	-		E1_2C2HB
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	129	1.000	Inparanoid score	I4629
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49595
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003527
OrthoInspector	1	1.000	-	-		otm43846
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12842
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5405
SonicParanoid	1	1.000	-	-		X2406
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.890